What are exogenous ketones’s main drawbacks?

Last Updated:
References
1.^Yu Q, Falkenhain K, Little JP, Wong KK, Nie J, Shi Q, Kong ZEffects of ketone supplements on blood β-hydroxybutyrate, glucose and insulin: A systematic review and three-level meta-analysis.Complement Ther Clin Pract.(2023-Aug)
2.^Kaja Falkenhain, Ali Daraei, Scott C Forbes, Jonathan P LittleEffects of Exogenous Ketone Supplementation on Blood Glucose: A Systematic Review and Meta-AnalysisAdv Nutr.(2022 Apr 5)
3.^Brooks E, Lamothe G, Nagpal TS, Imbeault P, Adamo K, Kara J, Doucet ÉAcute Ingestion of Ketone Monoesters and Precursors Do Not Enhance Endurance Exercise Performance: A Systematic Review and Meta-Analysis.Int J Sport Nutr Exerc Metab.(2022 May 1)
4.^Bolyard ML, Graziano CM, Fontaine KR, Sayer RD, Fisher G, Plaisance EPTolerability and Acceptability of an Exogenous Ketone Monoester and Ketone Monoester/Salt Formulation in Humans.Nutrients.(2023 Nov 22)
5.^Clarke K, Tchabanenko K, Pawlosky R, Carter E, Todd King M, Musa-Veloso K, Ho M, Roberts A, Robertson J, Vanitallie TB, Veech RLKinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects.Regul Toxicol Pharmacol.(2012 Aug)
6.^Adrian Soto-Mota, Hannah Vansant, Rhys D Evans, Kieran ClarkeSafety and tolerability of sustained exogenous ketosis using ketone monoester drinks for 28 days in healthy adultsRegul Toxicol Pharmacol.(2019 Dec)
7.^Stubbs BJ, Cox PJ, Evans RD, Santer P, Miller JJ, Faull OK, Magor-Elliott S, Hiyama S, Stirling M, Clarke KOn the Metabolism of Exogenous Ketones in HumansFront Physiol.(2017 Oct 30)
8.^Krolak-Salmon P, Swerdlow RH, Mastain T, Dive-Pouletty C, Pooley N, Kisomi MEfficacy and Safety of Exogenous Ketones in People with Mild Neurocognitive Disorder and Alzheimer's Disease: A Systematic Literature Review.Nutr Rev.(2024 Jul 24)
9.^Lv T, Liu C, Guo S, Wu M, Wang X, Zhang Z, Zhou J, Yao Y, Shen Z, Yang J, Sun S, Liu Z, Chi JTargeting Ketone Body Metabolism Improves Cardiac Function and Hemodynamics in Patients With Heart Failure: A Systematic Review and Meta-Analysis.Nutr Rev.(2025 Jan 28)
10.^Dhatariya KK, Glaser NS, Codner E, Umpierrez GEDiabetic ketoacidosis.Nat Rev Dis Primers.(2020-May-14)