CYP2E1 Inhibitors

CYP2E1 inhibitors include, but are not limited to, disulfiram and quercetin. See glossary page for more information.

Summary

CYP2E1 inhibitors are compounds that reduce the activity of the CYP2E1 enzyme, which can reduce drug metabolism, potentially impacting the effects of drug therapy.

CYP2E1 is a cytochrome P450 (CYP) enzyme with a minor role in drug metabolism, as well as the metabolism of some industrial chemicals and organic solvents. CYP2E1 is involved in the metabolism of any medications that are CYP2E1 substrates. CYP2E1 inhibitors can reduce the body’s metabolism of any of these substances.

The table below outlines some of the most common or clinically relevant CYP2E1 inhibitors.[1][2][3] Importantly, this list is not exhaustive.

CYP2E1 Inhibitors
Disulfiram
Quercetin

References

1.^Song Y, Li C, Liu G, Liu R, Chen Y, Li W, Cao Z, Zhao B, Lu C, Liu YDrug-Metabolizing Cytochrome P450 Enzymes Have Multifarious Influences on Treatment Outcomes.Clin Pharmacokinet.(2021-May)
3.^Hakkola J, Hukkanen J, Turpeinen M, Pelkonen OInhibition and induction of CYP enzymes in humans: an update.Arch Toxicol.(2020-Nov)