Can supplemental lutein affect cardiometabolic health in people with central obesity? Original paper
In this randomized controlled trial, supplementing with lutein improved blood lipids, reduced oxidative stress and blood pressure, and lowered advanced glycation end products in participants with central obesity.
This Study Summary was published on March 27, 2025.
The study
The 94 participants were adults with central obesity (excess fat around the waist and abdomen), and they took 10 mg of lutein or a placebo daily for 32 weeks.
Compared with placebo, supplemental lutein reduced diastolic blood pressure (−3.6 mmHg), total cholesterol (−0.5 mmol/L, −19.3 mg/dL), LDL cholesterol (−0.3 mmol/L, −11.6 mg/dL), apolipoprotein B (−0.1 g/L, −10 mg/dL), and malondialdehyde (−0.1 nmol/mL; a marker of oxidative stress).
Lutein also reduced the advanced glycation end products carboxyethyl lysin (−8.76 ng/mL), carboxymethyl lysine (−72.3 ng/mL), and methylglyoxal hydroimidazolone (−233.9 ng/mL).
The lutein manufacturer both supplied the supplement and partially funded this research.
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The results
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This Study Summary was published on March 27, 2025.