Strategies for correcting vitamin D deficiency in children with inflammatory bowel disease Original paper

In this randomized controlled trial in 74 children with vitamin D deficiency and inflammatory bowel disease, vitamin D3 administered as a single high dose was as effective as daily vitamin D3 at raising vitamin D levels over 12 months.

This Study Summary was published on June 10, 2025.

The study

This trial compared high-dose vitamin D3 to daily vitamin D3 for treatment of vitamin D deficiency (<50 nmol/L). Children (ages 3–11) were given a single dose of 400,000 IU of vitamin D3, and children 12 years or older were given a single dose of 800,000 IU. These groups were compared to a control group of children who received a daily dose of 2,000 IU for 12 months, and vitamin D levels were assessed at 3, 6, 9, and 12 months.

Vitamin D levels were similar between groups at each time interval.

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The results

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    This Study Summary was published on June 10, 2025.