High-dose vitamin D to balance hormones that regulate blood pressure and fluid balance in participants with heart failure Original paper

In this study, 80 participants with heart failure took 2 doses of 200,000 IU of vitamin D or a placebo. After 1 month, the vitamin D group reduced their plasma renin levels and increased their vitamin D levels compared to the placebo group. However, there were no changes in other parameters, such as blood pressure, heart rate, or cardiac function.

Renin is a hormone that is often elevated in people with heart failure. Renin activates the renin-angiotensin-aldosterone system and promotes water and sodium retention in the kidneys, leading to increased blood pressure.