What factors can influence the odds of having premature ovarian insufficiency? Original paper

In this meta-analysis of 38 observational studies in 10,126 women, factors like worse mental health, inadequate sleep, and smoking were associated with an increased odds of primary ovarian insufficiency, though methodological limitations reduce our confidence in these findings.

This Study Summary was published on April 21, 2025.

The study

Compared to the participants without primary ovarian insufficiency, the participants with primary ovarian insufficiency had increased odds of the following:

  • Previously having mumps (+480%)
  • Previous gynecological issues (abnormal menstruation, previous pelvic surgery, number of abortions; +171% to +384%)
  • Environmental exposures (hair dye, chemical exposure; +231% to +373%)
  • Mental health factors (poor mood, “survival stress”, Type A personality; +229% to +365%)
  • A family history of primary ovarian insufficiency (+334%)
  • Sleep deprivation (+234%)
  • Smoking (+175%)

The participants with primary ovarian insufficiency were less likely to be physically active (73% lower odds) and eat vegetables (57% lower odds) than those without primary ovarian insufficiency.

Funnel plots indicated publication bias in approximately half of the results, and the researchers did not adjust for potential confounders.

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The results

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    This Study Summary was published on April 21, 2025.