High-dose vitamin D decreases markers of muscle and kidney damage after traumatic injury Original paper

In this randomized controlled trial in 46 participants with traumatic injuries, supplementation with vitamin D3 helped prevent increases in creatine phosphokinase (CPK; a marker that may signal kidney injury when elevated).

This Study Summary was published on June 12, 2025.

The study

During the trial, participants with elevated CPK received either 300,000 IU of vitamin D3 or no treatment, and their CPK levels were tracked over 14 days.

The participants who received vitamin D3 had a decrease in CPK levels over the study period. However, the reductions in CPK levels did not lead to reduced rates of kidney injury or the need for dialysis.

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The results

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This Study Summary was published on June 12, 2025.