The study

The participants took either creatine monohydrate (20 grams daily for 5 days, followed by 5 grams daily for 23 days) or a placebo. After a 4-week washout period, they switched to the other intervention and repeated the experiment.

Creatine increased (improved) flow-mediated dilation and microvascular reperfusion rate, compared with the placebo. There were no differences between groups in other outcomes, including pulse wave velocity, oxidative stress biomarkers, or blood lipids.

At the time that the trial was conducted, one of the authors was a science adviser for Alzchem, a company that markets creatine monohydrate under the Creapure brand name.

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The results

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This Study Summary was published on April 24, 2025.