Beta-alanine has limited benefits in adults with overweight or obesity Original paper

In this randomized controlled trial, a beta-alanine supplement was well tolerated but showed minimal effects on cardiometabolic health markers.

This Study Summary was published on March 28, 2025.

The study

All 27 participants were adults with overweight or obesity. The participants took 4.8 grams of sustained-release beta-alanine or a placebo daily for 3 months.

The primary outcome assessed measures of feasibility and tolerance, such as supplement adherence, side effects, and participant retention. There was high adherence (92%), minimal side effects, and low dropout rates (1 participant in the beta-alanine group vs. 2 in the placebo group).

All of the biomarkers of cardiometabolic health (e.g., HbA1c and blood pressure) were considered exploratory, and no significant changes were observed.

The study was partially funded by the beta-alanine supplement’s manufacturer, which also had financial relationships with 2 of the authors.

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The results

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This Study Summary was published on March 28, 2025.