Autism Spectrum Disorder (ASD)

Last Updated: October 13, 2024

Autism spectrum disorder (ASD) is a neurodevelopmental condition that begins in early childhood. It affects a person’s ability to interact socially, communicate, and learn. ASD comes with varying degrees of differences, which is why it is called a “spectrum” disorder.

Autism Spectrum Disorder (ASD) falls under thePregnancy & Childrencategory.

What is autism spectrum disorder?

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that starts in early childhood and is marked by challenges in social communication and interaction, as well as repetitive behaviors and interests.

What are the main signs and symptoms of autism spectrum disorder?

The main signs and symptoms of autism spectrum disorder include difficulties with social communication and repetitive behaviors, and may involve issues such as delayed language and cognitive development, inability to maintain eye contact, and intense interests in specific topics. Additional symptoms can include seizures, gastrointestinal dysfunction, and sleep problems.

How is autism spectrum disorder diagnosed?

Autism spectrum disorder (ASD) is typically diagnosed through screenings recommended by the American Academy of Pediatrics at 18 and 24 months, during which healthcare providers use questionnaires, clinical observations, and cognitive tests. The specific testing methods and diagnosis are determined at the healthcare provider's discretion.

What are some of the main medical treatments for autism spectrum disorder?

There are no standard treatments for autism spectrum disorder (ASD) because it affects individuals differently, so treatments are customized to meet individual needs. Common approaches include behavior management programs, cognitive behavioral therapy, occupational therapy, neurofeedback, and symptom-specific medications.

Have any supplements been studied for autism spectrum disorder?

Several dietary supplements — including omega-3 fatty acids, melatonin, vitamin D, and a combination of vitamin B6 and magnesium — have been studied for autism spectrum disorder (ASD). Although omega-3 supplementation shows little evidence of effectiveness and vitamin B6 and magnesium have conflicting results, vitamin D supplementation shows promise, and melatonin may improve sleep and daytime behavior.

How could diet affect autism spectrum disorder?

Caregivers of children with autism spectrum disorder (ASD) often consider dietary approaches like gluten-free, casein-free diets and the specific carbohydrate diet, but evidence supporting their effectiveness is limited. Additionally, food selectivity in ASD highlights the importance of consulting with healthcare professionals to ensure proper nutrition.

Are there any other treatments for autism?

The FDA cautions against various products and therapies marketed for autism treatment, such as chelation therapy and hyperbaric oxygen therapy, because they may be potentially dangerous. It is advisable to consult a healthcare provider before considering any alternative treatments.

What causes autism?

Autism is influenced by both genetic and environmental factors, though the exact interactions between these influences is not fully understood and may differ among individuals.

Supplements Demystified: Get Our Unbiased, Evidence-Based Guide

Examine Database: Autism Spectrum Disorder (ASD)
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

References
  1. ^The content of this page was partially adapted from MedlinePlus of the National Library of Medicine, Autism Spectrum Disorder, last updated October 13, 2016
  2. ^The Centers for Disease Control and Prevention, Autism Spectrum Disorder Signs and Symptoms, last updated March 28, 2022
  3. ^The content of this page was partially adapted from MedlinePlus Autism Spectrum Disorder (ASD) Screening; last updated 2022 April 21
  4. ^Genovese A, Butler MGClinical Assessment, Genetics, and Treatment Approaches in Autism Spectrum Disorder (ASD).Int J Mol Sci.(2020-Jul-02)
  5. ^James S, Montgomery P, Williams KOmega-3 fatty acids supplementation for autism spectrum disorders (ASD)Cochrane Database Syst Rev.(2011 Nov 9)
  6. ^Rossignol DA, Frye REMelatonin in autism spectrum disorders: a systematic review and meta-analysisDev Med Child Neurol.(2011 Sep)
  7. ^Mazahery H, Camargo CA Jr, Conlon C, Beck KL, Kruger MC, von Hurst PRVitamin D and Autism Spectrum Disorder: A Literature ReviewNutrients.(2016 Apr 21)
  8. ^Nye C, Brice ACombined vitamin B6-magnesium treatment in autism spectrum disorderCochrane Database Syst Rev.(2005 Oct 19)
  9. ^Marí-Bauset S, Zazpe I, Mari-Sanchis A, Llopis-González A, Morales-Suárez-Varela MFood selectivity in autism spectrum disorders: a systematic review.J Child Neurol.(2014-Nov)
  10. ^Chaste P, Leboyer MAutism risk factors: genes, environment, and gene-environment interactions.Dialogues Clin Neurosci.(2012-Sep)
  11. ^Ann M Neumeyer, Amy Gates, Christine Ferrone, Hang Lee, Madhusmita MisraBone density in peripubertal boys with autism spectrum disordersJ Autism Dev Disord.(2013 Jul)
  12. ^B Kadesjö, C GillbergThe comorbidity of ADHD in the general population of Swedish school-age childrenJ Child Psychol Psychiatry.(2001 May)
  13. ^C Gillberg, E BillstedtAutism and Asperger syndrome: coexistence with other clinical disordersActa Psychiatr Scand.(2000 Nov)
  14. ^J L Bradshaw, D M SheppardThe neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralizationBrain Lang.(2000 Jun 15)
  15. ^Belinda A Gargaro, Nicole J Rinehart, John L Bradshaw, Bruce J Tonge, Dianne M SheppardAutism and ADHD: how far have we come in the comorbidity debate?Neurosci Biobehav Rev.(2011 Apr)
  16. ^
  17. ^,Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010.MMWR Surveill Summ.(2014-Mar-28)
  18. ^Robinson EB, Lichtenstein P, Anckarsäter H, Happé F, Ronald AExamining and interpreting the female protective effect against autistic behavior.Proc Natl Acad Sci U S A.(2013-Mar-26)
  19. ^Skuse DHImprinting, the X-chromosome, and the male brain: explaining sex differences in the liability to autism.Pediatr Res.(2000-Jan)
  20. ^Migeon BRWhy females are mosaics, X-chromosome inactivation, and sex differences in disease.Gend Med.(2007-Jun)
  21. ^Knickmeyer R, Baron-Cohen S, Fane BA, Wheelwright S, Mathews GA, Conway GS, Brook CG, Hines MAndrogens and autistic traits: A study of individuals with congenital adrenal hyperplasia.Horm Behav.(2006-Jun)
  22. ^Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn SSex-specific serum biomarker patterns in adults with Asperger's syndrome.Mol Psychiatry.(2011-Dec)
  23. ^Guyatt AL, Heron J, Knight Ble C, Golding J, Rai DDigit ratio and autism spectrum disorders in the Avon Longitudinal Study of Parents and Children: a birth cohort study.BMJ Open.(2015-Aug-25)
  24. ^Baron-Cohen S, Lombardo MV, Auyeung B, Ashwin E, Chakrabarti B, Knickmeyer RWhy are autism spectrum conditions more prevalent in males?PLoS Biol.(2011-Jun)
  25. ^Lai MC, Lombardo MV, Ruigrok AN, Chakrabarti B, Auyeung B, Szatmari P, Happé F, Baron-Cohen S,Quantifying and exploring camouflaging in men and women with autism.Autism.(2017-08)
  26. ^Keller R, Basta R, Salerno L, Elia MAutism, epilepsy, and synaptopathies: a not rare association.Neurol Sci.(2017-Aug)
  27. ^Anand V, Jauhari PAutism, Epilepsy and Intellectual Disability: A Clinical Conundrum.Indian J Pediatr.(2019-10)
  28. ^Ghaziuddin M, Ghaziuddin NBipolar Disorder and Psychosis in Autism.Psychiatr Clin North Am.(2021-03)
  29. ^Pan PY, Tammimies K, Bölte SThe Association Between Somatic Health, Autism Spectrum Disorder, and Autistic Traits.Behav Genet.(2020-07)
  30. ^Goines P, Van de Water JThe immune system's role in the biology of autism.Curr Opin Neurol.(2010-Apr)
  31. ^Onore C, Careaga M, Ashwood PThe role of immune dysfunction in the pathophysiology of autism.Brain Behav Immun.(2012-Mar)
  32. ^Stone WL, Basit H, Los EFragile X SyndromeStatPearls.(2022-06)
  33. ^Kaufmann WE, Kidd SA, Andrews HF, Budimirovic DB, Esler A, Haas-Givler B, Stackhouse T, Riley C, Peacock G, Sherman SL, Brown WT, Berry-Kravis EAutism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment.Pediatrics.(2017-Jun)
  34. ^Neul JLThe relationship of Rett syndrome and MECP2 disorders to autism.Dialogues Clin Neurosci.(2012-Sep)
  35. ^Satterstrom FK, Kosmicki JA, Wang J, Breen MS, De Rubeis S, An JY, Peng M, Collins R, Grove J, Klei L, Stevens C, Reichert J, Mulhern MS, Artomov M, Gerges S, Sheppard B, Xu X, Bhaduri A, Norman U, Brand H, Schwartz G, Nguyen R, Guerrero EE, Dias C, , , Betancur C, Cook EH, Gallagher L, Gill M, Sutcliffe JS, Thurm A, Zwick ME, Børglum AD, State MW, Cicek AE, Talkowski ME, Cutler DJ, Devlin B, Sanders SJ, Roeder K, Daly MJ, Buxbaum JDLarge-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.Cell.(2020-02-06)
  36. ^Choi L, An JYGenetic architecture of autism spectrum disorder: Lessons from large-scale genomic studies.Neurosci Biobehav Rev.(2021-09)
  37. ^Jiang HY, Xu LL, Shao L, Xia RM, Yu ZH, Ling ZX, Yang F, Deng M, Ruan BMaternal infection during pregnancy and risk of autism spectrum disorders: A systematic review and meta-analysis.Brain Behav Immun.(2016-Nov)
  38. ^Christensen J, Grønborg TK, Sørensen MJ, Schendel D, Parner ET, Pedersen LH, Vestergaard MPrenatal valproate exposure and risk of autism spectrum disorders and childhood autism.JAMA.(2013-Apr-24)
  39. ^Hultman CM, Sandin S, Levine SZ, Lichtenstein P, Reichenberg AAdvancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies.Mol Psychiatry.(2011-Dec)
  40. ^Sandin S, Hultman CM, Kolevzon A, Gross R, MacCabe JH, Reichenberg AAdvancing maternal age is associated with increasing risk for autism: a review and meta-analysis.J Am Acad Child Adolesc Psychiatry.(2012-May)
  41. ^Wu S, Wu F, Ding Y, Hou J, Bi J, Zhang ZAdvanced parental age and autism risk in children: a systematic review and meta-analysis.Acta Psychiatr Scand.(2017-Jan)
  42. ^Xu RT, Chang QX, Wang QQ, Zhang J, Xia LX, Zhong N, Yu YH, Zhong M, Huang QTAssociation between hypertensive disorders of pregnancy and risk of autism in offspring: a systematic review and meta-analysis of observational studies.Oncotarget.(2018-Jan-02)
  43. ^Lei XY, Li YJ, Ou JJ, Li YMAssociation between parental body mass index and autism spectrum disorder: a systematic review and meta-analysis.Eur Child Adolesc Psychiatry.(2019-Jul)
  44. ^Li YM, Ou JJ, Liu L, Zhang D, Zhao JP, Tang SYAssociation Between Maternal Obesity and Autism Spectrum Disorder in Offspring: A Meta-analysis.J Autism Dev Disord.(2016-Jan)
  45. ^Amin SB, Smith T, Wang HIs neonatal jaundice associated with Autism Spectrum Disorders: a systematic review.J Autism Dev Disord.(2011-Nov)
  46. ^Brown AS, Sourander A, Hinkka-Yli-Salomäki S, McKeague IW, Sundvall J, Surcel HMElevated maternal C-reactive protein and autism in a national birth cohort.Mol Psychiatry.(2014-Feb)
  47. ^Kosidou K, Dalman C, Widman L, Arver S, Lee BK, Magnusson C, Gardner RMMaternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden.Mol Psychiatry.(2016-10)
  48. ^Di Pietrantonj C, Rivetti A, Marchione P, Debalini MG, Demicheli VVaccines for measles, mumps, rubella, and varicella in children.Cochrane Database Syst Rev.(2021-11-22)
  49. ^Wilson K, Mills E, Ross C, McGowan J, Jadad AAssociation of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence.Arch Pediatr Adolesc Med.(2003-Jul)
  50. ^Jain A, Marshall J, Buikema A, Bancroft T, Kelly JP, Newschaffer CJAutism occurrence by MMR vaccine status among US children with older siblings with and without autism.JAMA.(2015-Apr-21)
  51. ^Kral TV, Souders MC, Tompkins VH, Remiker AM, Eriksen WT, Pinto-Martin JAChild Eating Behaviors and Caregiver Feeding Practices in Children with Autism Spectrum Disorders.Public Health Nurs.(2015)
  52. ^Hyman SL, Stewart PA, Schmidt B, Cain U, Lemcke N, Foley JT, Peck R, Clemons T, Reynolds A, Johnson C, Handen B, James SJ, Courtney PM, Molloy C, Ng PKNutrient intake from food in children with autism.Pediatrics.(2012-Nov)
  53. ^Summer Yule, Jillian Wanik, Elizabeth M Holm, Mary Beth Bruder, Ellen Shanley, Christina Q Sherman, Megan Fitterman, Jaclyn Lerner, Monica Marcello, Nicole Parenchuck, Corinne Roman-White, Madeline ZiffNutritional Deficiency Disease Secondary to ARFID Symptoms Associated with Autism and the Broad Autism Phenotype: A Qualitative Systematic Review of Case Reports and Case SeriesJ Acad Nutr Diet.(2021 Mar)
  54. ^Bandini et allFood Selectivity in Children with Autism Spectrum Disorders and Typically Developing ChildrenJournal of Pediatrics.(2010-08)
  55. ^Monteiro MA, Santos AAAD, Gomes LMM, Rito RVVFAUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW ABOUT NUTRITIONAL INTERVENTIONS.Rev Paul Pediatr.(2020)
  56. ^Karhu E, Zukerman R, Eshraghi RS, Mittal J, Deth RC, Castejon AM, Trivedi M, Mittal R, Eshraghi AANutritional interventions for autism spectrum disorder.Nutr Rev.(2020-07-01)
  57. ^Marí-Bauset S, Zazpe I, Mari-Sanchis A, Llopis-González A, Morales-Suárez-Varela MEvidence of the gluten-free and casein-free diet in autism spectrum disorders: a systematic reviewJ Child Neurol.(2014 Dec)
  58. ^Winburn E, Charlton J, McConachie H, McColl E, Parr J, O'Hare A, Baird G, Gringras P, Wilson DC, Adamson A, Adams S, Le Couteur AParents' and child health professionals' attitudes towards dietary interventions for children with autism spectrum disordersJ Autism Dev Disord.(2014 Apr)
  59. ^Panksepp JA neurochemical theory of autismTrends in Neurosciences.(1979)
  60. ^Shattock P, Whiteley PBiochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical interventionExpert Opin Ther Targets.(2002 Apr)
  61. ^van De Sande MM, van Buul VJ, Brouns FJAutism and nutrition: the role of the gut-brain axisNutr Res Rev.(2014 Dec)
  62. ^de Magistris L, Familiari V, Pascotto A, Sapone A, Frolli A, Iardino P, Carteni M, De Rosa M, Francavilla R, Riegler G, Militerni R, Bravaccio CAlterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relativesJ Pediatr Gastroenterol Nutr.(2010 Oct)
  63. ^Dalton N, Chandler S, Turner C, Charman T, Pickles A, Loucas T, Simonoff E, Sullivan P, Baird GGut permeability in autism spectrum disordersAutism Res.(2014 Jun)
  64. ^Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BDAutism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theoryAnal Bioanal Chem.(2007 Aug)
  65. ^Cass H, Gringras P, March J, McKendrick I, O'Hare AE, Owen L, Pollin CAbsence of urinary opioid peptides in children with autismArch Dis Child.(2008 Sep)
  66. ^Millward C, Ferriter M, Calver S, Connell-Jones GGluten- and casein-free diets for autistic spectrum disorderCochrane Database Syst Rev.(2008 Apr 16)
  67. ^Elder JH, Shankar M, Shuster J, Theriaque D, Burns S, Sherrill LThe gluten-free, casein-free diet in autism: results of a preliminary double blind clinical trialJ Autism Dev Disord.(2006 Apr)
  68. ^Seung, H., Rogalski, Y., Shankar, M., & Elder, J.The gluten- and casein-free diet and autism: Communication outcomes from a preliminary double-blind clinical trial.Journal of Medical Speech-Language Pathology.(2007)
  69. ^Navarro F, Pearson DA, Fatheree N, Mansour R, Hashmi SS, Rhoads JMAre 'leaky gut' and behavior associated with gluten and dairy containing diet in children with autism spectrum disorders?Nutr Neurosci.(2015 May)
  70. ^Pusponegoro HD, Ismael S, Firmansyah A, Sastroasmoro S, Vandenplas YGluten and casein supplementation does not increase symptoms in children with autism spectrum disorderActa Paediatr.(2015 Nov)
  71. ^Hyman SL, Stewart PA, Foley J, Cain U, Peck R, Morris DD, Wang H, Smith TThe Gluten-Free/Casein-Free Diet: A Double-Blind Challenge Trial in Children with AutismJ Autism Dev Disord.(2016 Jan)
  72. ^Piwowarczyk A, Horvath A, Łukasik J, Pisula E, Szajewska HGluten- and casein-free diet and autism spectrum disorders in children: a systematic reviewEur J Nutr.(2018 Mar)
  73. ^Sathe N, Andrews JC, McPheeters ML, Warren ZENutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic ReviewPediatrics.(2017 Jun)
  74. ^Buie T, Campbell DB, Fuchs GJ 3rd, Furuta GT, Levy J, Vandewater J, Whitaker AH, Atkins D, Bauman ML, Beaudet AL, Carr EG, Gershon MD, Hyman SL, Jirapinyo P, Jyonouchi H, Kooros K, Kushak R, Levitt P, Levy SE, Lewis JD, Murray KF, Natowicz MR, Sabra A, Wershil BK, Weston SC, Zeltzer L, Winter HEvaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus reportPediatrics.(2010 Jan)
  75. ^Vasa RA, Mazurek MO, Mahajan R, Bennett AE, Bernal MP, Nozzolillo AA, Arnold LE, Coury DLAssessment and Treatment of Anxiety in Youth With Autism Spectrum DisordersPediatrics.(2016 Feb)
  76. ^Zwaigenbaum L, Bauman ML, Choueiri R, Kasari C, Carter A, Granpeesheh D, Mailloux Z, Smith Roley S, Wagner S, Fein D, Pierce K, Buie T, Davis PA, Newschaffer C, Robins D, Wetherby A, Stone WL, Yirmiya N, Estes A, Hansen RL, McPartland JC, Natowicz MREarly Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and ResearchPediatrics.(2015 Oct)
Examine Database References
  1. Autism Symptoms - Levine J, Aviram A, Holan A, Ring A, Barak Y, Belmaker RHInositol treatment of autismJ Neural Transm.(1997)
  2. Autism Symptoms - Hardan AY, Fung LK, Libove RA, Obukhanych TV, Nair S, Herzenberg LA, Frazier TW, Tirouvanziam RA randomized controlled pilot trial of oral N-acetylcysteine in children with autismBiol Psychiatry.(2012 Jun 1)
  3. Autism Symptoms - Ghanizadeh A, Moghimi-Sarani EA randomized double blind placebo controlled clinical trial of N-Acetylcysteine added to risperidone for treating autistic disordersBMC Psychiatry.(2013 Jul 25)
  4. Autism Symptoms - Lee TM, Lee KM, Lee CY, Lee HC, Tam KW, Loh EWEffectiveness of -acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trials.Aust N Z J Psychiatry.(2021-Feb)
  5. Autism Symptoms - Niederhofer HFirst preliminary results of an observation of Ginkgo Biloba treating patients with autistic disorderPhytother Res.(2009 Nov)
  6. Autism Symptoms - Hasanzadeh E, Mohammadi MR, Ghanizadeh A, Rezazadeh SA, Tabrizi M, Rezaei F, Akhondzadeh SA double-blind placebo controlled trial of Ginkgo biloba added to risperidone in patients with autistic disordersChild Psychiatry Hum Dev.(2012 Oct)
  7. Autism Symptoms - Saeid Doaei, Fatemeh Bourbour, Zohreh Teymoori, Faranak Jafari, Naser Kalantari, Saheb Abbas Torki, Narges Ashoori, Shiva Nemat Gorgani, Maryam GholamalizadehThe effect of omega-3 fatty acids supplementation on social and behavioral disorders of children with autism: a randomized clinical trialPediatr Endocrinol Diabetes Metab.(2021)
  8. Autism Symptoms - Mousavinejad E, Ghaffari MA, Riahi F, Hajmohammadi M, Tiznobeyk Z, Mousavinejad MCoenzyme Q10 supplementation reduces oxidative stress and decreases antioxidant enzyme activity in children with autism spectrum disordersPsychiatry Res.(2018 Jul)
  9. Autism Symptoms - Geier DA, Kern JK, Davis G, King PG, Adams JB, Young JL, Geier MRA prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disordersMed Sci Monit.(2011 Jun)
  10. Autism Symptoms - Lin CH, Zeng T, Lu CW, Li DY, Liu YY, Li BM, Chen SQ, Deng YHEfficacy and safety of Bacteroides fragilis BF839 for pediatric autism spectrum disorder: a randomized clinical trial.Front Nutr.(2024)
  11. Autism Symptoms - Soleimanpour S, Abavisani M, Khoshrou A, Sahebkar AProbiotics for autism spectrum disorder: An updated systematic review and meta-analysis of effects on symptoms.J Psychiatr Res.(2024 Sep 11)
  12. Autism Symptoms - Kotowska M, Kołodziej M, Szajewska H, Łukasik JThe impact of probiotics on core autism symptoms - A systematic review and meta-analysis of randomized clinical trials.Clin Nutr ESPEN.(2024 Aug 20)
  13. Autism Risk - Friel C, Leyland AH, Anderson JJ, Havdahl A, Borge T, Shimonovich M, Dundas RPrenatal Vitamins and the Risk of Offspring Autism Spectrum Disorder: Systematic Review and Meta-Analysis.Nutrients.(2021-Jul-26)