Benign Prostatic Hyperplasia (BPH)

Last Updated: October 13, 2024

Benign prostatic hyperplasia (BPH) is a condition in which the prostate gland is enlarged and not cancerous. It often leads to lower urinary tract symptoms and is very common in older men (>50 years old).

Benign Prostatic Hyperplasia (BPH) falls under theMen’s Healthcategory.

What is BPH?

Benign prostatic hyperplasia is a noncancerous enlargement of the prostate gland, which is located below the bladder and surrounds the urethra. It commonly affects older men; approximately 50% of men over age 50 show signs of this condition, and its prevalence increases with age.

What are the main signs and symptoms of BPH?

The main signs and symptoms of benign prostatic hyperplasia include a frequent and urgent need to urinate, difficulty in starting a urine stream, a weak or interrupted stream, dribbling at the end of urination, and a feeling of incomplete urination. However, the severity of symptoms does not always correlate with the size of the prostate because some men with enlarged prostates may experience few symptoms.

How is BPH diagnosed?

BPH is diagnosed primarily through patient symptoms assessed via the International Prostate Symptom Score questionnaire, medical history, and a digital rectal exam. A urinalysis is also conducted to rule out other conditions that may cause similar urinary tract symptoms.

What are some of the main medical treatments for BPH?

Medical treatments for benign prostatic hyperplasia depend on symptom severity and include watchful waiting, medications like alpha-blockers and 5-alpha reductase inhibitors, and, if necessary, minimally invasive procedures or surgery to reduce the prostate size or widen the urethra.

Have any supplements been studied for BPH?

Research on supplements for benign prostatic hyperplasia has primarily focused on polyphenols due to their antioxidant and anti-inflammatory properties, and saw palmetto is the most studied. However, most studies have been conducted in rodents rather than humans.

How could diet affect BPH?

Obesity and metabolic syndrome are associated with an increased risk of benign prostatic hyperplasia (BPH), which suggests that a healthy diet promoting weight loss may be beneficial. Additionally, reducing total liquid intake and limiting caffeinated and alcoholic beverages can help manage BPH symptoms.

Are there any other treatments for BPH?

Physical activity that follows the World Health Organization guidelines is recommended to improve the cardiometabolic risk factors associated with benign prostatic hyperplasia, whereas over-the-counter decongestants should be avoided because they may worsen urinary symptoms. Additionally, limited evidence indicates that acupuncture might help alleviate lower urinary tract symptoms.

What causes BPH?

The exact causes of benign prostatic hyperplasia (BPH) are not fully understood, but factors such as hormones, genetics, dietary influences, inflammation, oxidative stress, and metabolic syndrome have been associated with its development. Additionally, having a first-degree relative with BPH can increase the risk by 4 times.

Supplements Demystified: Get Our Unbiased, Evidence-Based Guide

Examine Database: Benign Prostatic Hyperplasia (BPH)
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

References
  1. ^National Institute of Diabetes and Digestive and Kidney DiseasesProstate Enlargement (Benign Prostatic Hyperplasia(2014-09)
  2. ^Chughtai B, Forde JC, Thomas DD, Laor L, Hossack T, Woo HH, Te AE, Kaplan SABenign prostatic hyperplasia.Nat Rev Dis Primers.(2016-05-05)
  3. ^The content of this page was partially adapted from MedlinePlus of the National Library of Medicine
  4. ^Lerner LB, McVary KT, Barry MJ, Bixler BR, Dahm P, Das AK, Gandhi MC, Kaplan SA, Kohler TS, Martin L, Parsons JK, Roehrborn CG, Stoffel JT, Welliver C, Wilt TJManagement of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA GUIDELINE PART I-Initial Work-up and Medical Management.J Urol.(2021-10)
  5. ^Mitsunari K, Miyata Y, Matsuo T, Mukae Y, Otsubo A, Harada J, Kondo T, Matsuda T, Ohba K, Sakai HPharmacological Effects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia.Molecules.(2021-Jan-16)
  6. ^Homma Y, Gotoh M, Kawauchi A, Kojima Y, Masumori N, Nagai A, Saitoh T, Sakai H, Takahashi S, Ukimura O, Yamanishi T, Yokoyama O, Yoshida M, Maeda KClinical guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia.Int J Urol.(2017-10)
  7. ^Zhang W, Ma L, Bauer BA, Liu Z, Lu YAcupuncture for benign prostatic hyperplasia: A systematic review and meta-analysis.PLoS One.(2017)
  8. ^Ng M, Baradhi KMBenign Prostatic HyperplasiaStatPearls.(2022-05)
  9. ^Sanda MG, Beaty TH, Stutzman RE, Childs B, Walsh PCGenetic susceptibility of benign prostatic hyperplasia.J Urol.(1994-Jul)
  10. ^Omran A, Leca BM, Oštarijaš E, Graham N, Da Silva AS, Zaïr ZM, Miras AD, le Roux CW, Vincent RP, Cardozo L, Dimitriadis GKMetabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors.Ther Adv Endocrinol Metab.(2021)
  11. ^Roehrborn CGBenign prostatic hyperplasia: an overview.Rev Urol.(2005)
  12. ^National Institute of Diabetes and Digestive and Kidney DiseasesProstate Enlargement (Benign Prostatic Hyperplasia(2014-09)
  13. ^Middleton LW, Shen Z, Varma S, Pollack AS, Gong X, Zhu S, Zhu C, Foley JW, Vennam S, Sweeney RT, Tu K, Biscocho J, Eminaga O, Nolley R, Tibshirani R, Brooks JD, West RB, Pollack JRGenomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis.JCI Insight.(2019-05-16)
  14. ^Parsons JK, Sarma AV, McVary K, Wei JTObesity and benign prostatic hyperplasia: clinical connections, emerging etiological paradigms and future directions.J Urol.(2013-Jan)
  15. ^Eschely Mampa et al.The correlation between obesity and prostate volume in patients with benign prostatic hyperplasia at Charlotte Maxeke Johannesburg Academic Hospital
  16. ^Lu Yong et al. The Effect of Weight Losing to Benign Prostate Hyperplasia Patients with Metabolic Syndrome
  17. ^Parsons JK, Im RAlcohol consumption is associated with a decreased risk of benign prostatic hyperplasia.J Urol.(2009-Oct)
  18. ^Crispo A, Talamini R, Gallus S, Negri E, Gallo A, Bosetti C, La Vecchia C, Dal Maso L, Montella MAlcohol and the risk of prostate cancer and benign prostatic hyperplasia.Urology.(2004-Oct)
  19. ^Giorgio Ivan Russo, Giuseppe Broggi, Andrea Cocci, Paolo Capogrosso, Marco Falcone, Ioannis Sokolakis, Murat Gül, Rosario Caltabiano, Marina Di MauroRelationship between Dietary Patterns with Benign Prostatic Hyperplasia and Erectile Dysfunction: A Collaborative ReviewNutrients.(2021 Nov 19)
  20. ^Jalalinia SF, Raei M, Naseri-Salahshour V, Varaei SThe Effect of Pelvic Floor Muscle Strengthening Exercise on Urinary Incontinence and Quality of Life in Patients after Prostatectomy: a Randomized Clinical Trial.J Caring Sci.(2020-Mar)
Examine Database References
  1. Benign Prostatic Hyperplasia Symptoms - Wilt T, Ishani A, Mac Donald R, Rutks I, Stark GPygeum africanum for benign prostatic hyperplasiaCochrane Database Syst Rev.(2002)
  2. Benign Prostatic Hyperplasia Symptoms - Suter A, Saller R, Riedi E, Heinrich MImproving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trialPhytother Res.(2013 Feb)
  3. Benign Prostatic Hyperplasia Symptoms - Bent S, Kane C, Shinohara K, Neuhaus J, Hudes ES, Goldberg H, Avins ALSaw palmetto for benign prostatic hyperplasiaN Engl J Med.(2006 Feb 9)
  4. Benign Prostatic Hyperplasia Symptoms - MacDonald R, Tacklind JW, Rutks I, Wilt TJSerenoa repens monotherapy for benign prostatic hyperplasia (BPH): an updated Cochrane systematic reviewBJU Int.(2012 Jun)
  5. Benign Prostatic Hyperplasia Symptoms - Barry MJ, Meleth S, Lee JY, Kreder KJ, Avins AL, Nickel JC, Roehrborn CG, Crawford ED, Foster HE Jr, Kaplan SA, McCullough A, Andriole GL, Naslund MJ, Williams OD, Kusek JW, Meyers CM, Betz JM, Cantor A, McVary KT, Complementary and Alternative Medicine for Urological Symptoms (CAMUS) Study GroupEffect of increasing doses of saw palmetto extract on lower urinary tract symptoms: a randomized trialJAMA.(2011 Sep 28)
  6. Benign Prostatic Hyperplasia Symptoms - Willetts KE, Clements MS, Champion S, Ehsman S, Eden JASerenoa repens extract for benign prostate hyperplasia: a randomized controlled trialBJU Int.(2003 Aug)
  7. Benign Prostatic Hyperplasia Symptoms - Bertaccini A, Giampaoli M, Cividini R, Gattoni GL, Sanseverino R, Realfonso T, Napodano G, Fandella A, Guidoni E, Prezioso D, Galasso R, Cicalese C, Scattoni V, Armenio A, Conti G, Corinti M, Spasciani R, Liguori G, Lampropoulou N, Martorana GObservational database serenoa repens (DOSSER): overview, analysis and results. A multicentric SIUrO (Italian Society of Oncological Urology) projectArch Ital Urol Androl.(2012 Sep)
  8. Benign Prostatic Hyperplasia Symptoms - Safarinejad MRUrtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover studyJ Herb Pharmacother.(2005)
  9. Benign Prostatic Hyperplasia Symptoms - lker Durak, PhD, Erdal Yılmaz, MD, Erdinç Devrim, MD, Hakkı Perk, MD, Murat Kaçmaz, MDConsumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancerNutrition Research.()