Coronary Artery Disease (CAD)
Coronary artery disease (CAD; sometimes called coronary heart disease, or CHD) is a common kind of heart disease caused by atherosclerosis of the heart’s arteries. Diet and exercise can play a pretty big role to both prevent and treat it. Smoking, family history, high blood pressure and high cholesterol are major risk factors.
Coronary Artery Disease (CAD) falls under theCardiovascular HealthandHealthy Aging & Longevitycategories.
Last Updated:August 16, 2022
Coronary artery disease (CAD; sometimes called coronary heart disease, or CHD) is the most common kind of heart disease. It happens when the arteries that feed blood to the heart muscles harden and get clogged through atherosclerosis. This process starves the heart of the oxygen and nutrients it needs to function well. Worsening CAD can lead to permanent heart damage and ultimately death. [1]
Damage to the coronary arteries begins early in life, and is usually without major symptoms until things get pretty bad. At that point, one of the main symptoms of CAD is chest pain (angina) that lasts on the order of minutes (as opposed to hours or seconds)[2]. However, the specifics of how this feels, when it occurs, and what’s associated with the pain depend on the specifics of the clinical disease; heart attacks (where a clot breaks off from a ruptured athrosclerotic plaque and blocks a narrower downstream artery) are different from, say, stable ischemic heart disease (where pain appears upon exertion and settles down afterwards).
The specifics of how chest pain feels, along with risk factors such as high cholesterol, high blood pressure, diabetes, lifestyle factors such as smoking, and a family history of cardiovascular diseases is often enough to raise a strong suspicion of CAD. Physical examination and additional testing by a medical professional such as imaging studies and blood work can provide further evidence.[3]
The specifics of medical treatment ultimately depends on the specifics of the person and the clinical disease they have. The treatments tend to fall into a few categories:
- Medically treating underlying risk factors to slow CAD progression. For instance, statins can be used to lower cholesterol and prevent further heart damage
- Drugs for symptom relief. For example, nitroglycerin can be used in people with stable ischemic heart disease to reduce short-term chest pain. Drugs that work on the heart like beta-blockers and calcium-channel blockers are often used to control pain and discomfort in the longer term, and also may help improve other outcomes in people who have established clinical disease[3]
- In severe cases, invasive procedures like coronary artery catheterizations with stenting, or surgeries such as coronary artery bypass grafting (CABG) are sometimes used
Medical treatments are ideally added on top of lifestyle changes that can help slow CAD progression. Things like quitting smoking and exercise can help a lot.
Yes, many supplements have been studied for both preventing clinical CAD as well as in people who already have CAD.[4] Given that high blood pressure and high cholesterol cause CAD, supplements that affect those outcomes may also affect the risk of CAD progression.
There’s a big connection, although there’s still some controversy around the details, such as whether or not limiting saturated fat without considering what it’s being replaced with will do much.[5][6][7] Just like with atherosclerosis, guidelines suggest that a diet abundant in vegetables, fruits, legumes, nuts, whole grains, can help reduce the risk of CAD.[8] Weight loss for people with higher BMIs may also play a role in preventing CAD, although the current evidence suggests that modest weight loss (in the 5-10 kg range) may have limited benefits.[9]
Exercise can play a big role in preventing CAD[8] and also can help people who have CAD improve their health.[10] Guidelines suggest that the role of resistance training in preventing CAD is unclear, but resistance training is still encouraged.[8]
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Our Supplement Guides give you unbiased research-based recommendations that you can immediately apply to improve your health. Coronary Artery Disease (CAD) is related to the following Supplement Guide:- ^MedlinePlus: Coronary artery disease
- ^Essential Evidence Plus: Coronary Heart Disease: Diagnosis. Last updated 12/13/19. Accessed 4/28/22.
- ^Juhani Knuuti, William Wijns, Antti Saraste, Davide Capodanno, Emanuele Barbato, Christian Funck-Brentano, Eva Prescott, Robert F Storey, Christi Deaton, Thomas Cuisset, Stefan Agewall, Kenneth Dickstein, Thor Edvardsen, Javier Escaned, Bernard J Gersh, Pavel Svitil, Martine Gilard, David Hasdai, Robert Hatala, Felix Mahfoud, Josep Masip, Claudio Muneretto, Marco Valgimigli, Stephan Achenbach, Jeroen J Bax, ESC Scientific Document Group2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromesEur Heart J.(2020 Jan 14)
- ^Jeffrey Knox, Barak GasterDietary supplements for the prevention and treatment of coronary artery diseaseJ Altern Complement Med.(Jan-Feb 2007)
- ^Arne Astrup, Faidon Magkos, Dennis M Bier, J Thomas Brenna, Marcia C de Oliveira Otto, James O Hill, Janet C King, Andrew Mente, Jose M Ordovas, Jeff S Volek, Salim Yusuf, Ronald M KraussSaturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art ReviewJ Am Coll Cardiol.(2020 Aug 18)
- ^Penny M Kris-Etherton, Ronald M KraussPublic health guidelines should recommend reducing saturated fat consumption as much as possible: YESAm J Clin Nutr.(2020 Jul 1)
- ^Lee Hooper, Nicole Martin, Oluseyi F Jimoh, Christian Kirk, Eve Foster, Asmaa S AbdelhamidReduction in saturated fat intake for cardiovascular diseaseCochrane Database Syst Rev.(2020 May 19)
- ^Donna K Arnett, Roger S Blumenthal, Michelle A Albert, Andrew B Buroker, Zachary D Goldberger, Ellen J Hahn, Cheryl Dennison Himmelfarb, Amit Khera, Donald Lloyd-Jones, J William McEvoy, Erin D Michos, Michael D Miedema, Daniel Muñoz, Sidney C Smith Jr, Salim S Virani, Kim A Williams Sr, Joseph Yeboah, Boback Ziaeian2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesCirculation.(2019 Sep 10)
- ^Tiffany M Powell-Wiley, Paul Poirier, Lora E Burke, Jean-Pierre Després, Penny Gordon-Larsen, Carl J Lavie, Scott A Lear, Chiadi E Ndumele, Ian J Neeland, Prashanthan Sanders, Marie-Pierre St-Onge, American Heart Association Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Epidemiology and Prevention; and Stroke CouncilObesity and Cardiovascular Disease: A Scientific Statement From the American Heart AssociationCirculation.(2021 May 25)
- ^Grace Dibben, James Faulkner, Neil Oldridge, Karen Rees, David R Thompson, Ann-Dorthe Zwisler, Rod S TaylorExercise-based cardiac rehabilitation for coronary heart diseaseCochrane Database Syst Rev.(2021 Nov 6)
- ^Allan D Sniderman, George Thanassoulis, Tamara Glavinovic, Ann Marie Navar, Michael Pencina, Alberico Catapano, Brian A FerenceApolipoprotein B Particles and Cardiovascular Disease: A Narrative ReviewJAMA Cardiol.(2019 Dec 1)
- ^Carr SS, Hooper AJ, Sullivan DR, Burnett JRNon-HDL-cholesterol and apolipoprotein B compared with LDL-cholesterol in atherosclerotic cardiovascular disease risk assessment.Pathology.(2019-Feb)
- ^Fonseca L, Paredes S, Ramos H, Oliveira JC, Palma IApolipoprotein B and non-high-density lipoprotein cholesterol reveal a high atherogenicity in individuals with type 2 diabetes and controlled low-density lipoprotein-cholesterol.Lipids Health Dis.(2020-Jun-06)
- ^Kivimäki M, Steptoe AEffects of stress on the development and progression of cardiovascular disease.Nat Rev Cardiol.(2018-04)
- ^Libby P, Nahrendorf M, Swirski FKLeukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum".J Am Coll Cardiol.(2016-Mar-08)
- ^Vaccarino V, Almuwaqqat Z, Kim JH, Hammadah M, Shah AJ, Ko YA, Elon L, Sullivan S, Shah A, Alkhoder A, Lima BB, Pearce B, Ward L, Kutner M, Hu Y, Lewis TT, Garcia EV, Nye J, Sheps DS, Raggi P, Bremner JD, Quyyumi AAAssociation of Mental Stress-Induced Myocardial Ischemia With Cardiovascular Events in Patients With Coronary Heart Disease.JAMA.(2021-11-09)
- ^Schneider RH, Grim CE, Rainforth MV, Kotchen T, Nidich SI, Gaylord-King C, Salerno JW, Kotchen JM, Alexander CNStress reduction in the secondary prevention of cardiovascular disease: randomized, controlled trial of transcendental meditation and health education in Blacks.Circ Cardiovasc Qual Outcomes.(2012-Nov)
- ^Levine GN, Lange RA, Bairey-Merz CN, Davidson RJ, Jamerson K, Mehta PK, Michos ED, Norris K, Ray IB, Saban KL, Shah T, Stein R, Smith SC,Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association.J Am Heart Assoc.(2017-Sep-28)
- ^Roberts R, Stewart AFGenes and coronary artery disease: where are we?J Am Coll Cardiol.(2012-Oct-30)
- ^Brown MS, Goldstein JLReceptor-mediated control of cholesterol metabolism.Science.(1976-Jan-16)
- ^Ison HE, Clarke SL, Knowles JWFamilial HypercholesterolemiaGeneReviews.(2014-01)
- ^Brunham LR, Hegele RAWhat Is the Prevalence of Familial Hypercholesterolemia?ATVB.(2021 Aug)
- ^Nordestgaard BG, Langsted ALipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology.J Lipid Res.(2016-11)
- ^Wilson DP, Jacobson TA, Jones PH, Koschinsky ML, McNeal CJ, Nordestgaard BG, Orringer CEUse of Lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association.J Clin Lipidol.(2019)
- ^Tsai AK, Li N, Hanson NQ, Tsai MY, Tang WAssociations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European-American population.Atherosclerosis.(2009-Dec)
- Triglycerides - Nasim Abedimanesh, S Zahra Bathaie, Saeed Abedimanesh, Behrooz Motlagh, Ahmad Separham, Alireza OstadrahimiSaffron and crocin improved appetite, dietary intakes and body composition in patients with coronary artery diseaseJ Cardiovasc Thorac Res.(2017)
- Triglycerides - Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, Stehle P, Koertke H, Koerfer RVitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markersAm J Clin Nutr.(2009 May)
- Risk Of Cardiovascular Disease - Wang L, Manson JE, Song Y, Sesso HDSystematic review: Vitamin D and calcium supplementation in prevention of cardiovascular eventsAnn Intern Med.(2010 Mar 2)
- Triglycerides - Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur ASEffect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarctionMol Cell Biochem.(2003 Apr)
- Triglycerides - Jorat MV, Tabrizi R, Mirhosseini N, Lankarani KB, Akbari M, Heydari ST, Mottaghi R, Asemi ZThe effects of coenzyme Q10 supplementation on lipid profiles among patients with coronary artery disease: a systematic review and meta-analysis of randomized controlled trials.Lipids Health Dis.(2018-Oct-09)
- Oxidative Stress Biomarkers - Mirhashemi SM, Najafi V, Raygan F, Asemi ZThe effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trialARYA Atheroscler.(2016 Jul)
- Oxidative Stress Biomarkers - Lee BJ, Huang YC, Chen SJ, Lin PTCoenzyme Q10 supplementation reduces oxidative stress and increase antioxidant enzyme activity in patients with coronary artery diseaseNutrition.(2011 Oct 11)
- Triglycerides - Mirzabeigi P, Mohammadpour AH, Salarifar M, Gholami K, Mojtahedzadeh M, Javadi MRThe Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled TrialIran J Pharm Res.(2015 Spring)
- Triglycerides - Noakes M, Foster PR, Keogh JB, James AP, Mamo JC, Clifton PMComparison of isocaloric very low carbohydrate/high saturated fat and high carbohydrate/low saturated fat diets on body composition and cardiovascular riskNutr Metab (Lond).(2006 Jan 11)
- Triglycerides - Budoff MJ, Takasu J, Flores FR, Niihara Y, Lu B, Lau BH, Rosen RT, Amagase HInhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary studyPrev Med.(2004 Nov)
- Triglycerides - Phelps S, Harris WSGarlic supplementation and lipoprotein oxidation susceptibilityLipids.(1993 May)
- Triglycerides - Sobenin IA, Pryanishnikov VV, Kunnova LM, Rabinovich YA, Martirosyan DM, Orekhov ANThe effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery diseaseLipids Health Dis.(2010 Oct 19)
- Heart Rate - Verma SK, Rajeevan V, Jain P, Bordia AEffect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery diseaseIndian J Physiol Pharmacol.(2005 Jan)
- Triglycerides - Maryam Akbari, Omid Reza Tamtaji, Kamran B Lankarani, Reza Tabrizi, Ehsan Dadgostar, Neda Haghighat, Fariba Kolahdooz, Amir Ghaderi, Mohammad Ali Mansournia, Zatollah AsemiThe effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trialsLipids Health Dis.(2020 Feb 17)
- Triglycerides - Consolato Sergi, Bonnie Chiu, Joseph Feulefack, Fan Shen, Brian ChiuUsefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trialsArch Med Sci Atheroscler Dis.(2020 May 30)
- Triglycerides - Sahebkar AEffects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials.Nutr Rev.(2013-Dec)
- Total cholesterol - Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados ECardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery diseaseClin Hemorheol Microcirc.(2012 Jan 1)
- Total cholesterol - Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AYThe effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.Med Clin (Barc).(2022-Jun-24)
- TNF-Alpha - Melodi Omraninava, Bahman Razi, Saeed Aslani, Danyal Imani, Tannaz Jamialahmadi, Amirhossein SahebkarEffect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trialsEur J Pharmacol.(2021 Oct 5)
- TNF-Alpha - Haghighatdoost F, Hariri MCan resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.Eur J Clin Nutr.(2019-Mar)
- C-Reactive Protein (CRP) - Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SDEvidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.Ageing Res Rev.(2018-Sep)
- Plasminogen Inhibitor-1 - Mohammadipoor N, Shafiee F, Rostami A, Kahrizi MS, Soleimanpour H, Ghodsi M, Ansari MJ, Bokov DO, Jannat B, Mosharkesh E, Pour Abbasi MSResveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)
- Triglycerides - Bor-Jen Lee, Jun-Shuo Lin, Yi-Chin Lin, Ping-Ting LinEffects of L-carnitine supplementation on lipid profiles in patients with coronary artery diseaseLipids Health Dis.(2016 Jun 17)
- Body Fat - Seyed Mostafa Nachvak, Maryam Shabanpur, Roghayeh Mostafai, Reza Heidari Moghaddam, Jalal MoludiL-Carnitine supplementation reduces biomarkers of inflammatory and oxidative stress in patients with coronary artery disease: a randomised controlled trialArch Physiol Biochem.(2020 Aug 20)
- TNF-Alpha - Bor-Jen Lee, Jun-Shuo Lin, Yi-Chin Lin, Ping-Ting LinAntiinflammatory effects of L-carnitine supplementation (1000 mg/d) in coronary artery disease patientsNutrition.(2015 Mar)
- Apolipoprotein B - Ali Sheikhi, Kurosh Djafarian, Moein Askarpour, Sakineh Shab-BidarThe effects of supplementation with L-carnitine on apolipoproteins: A systematic review and meta-analysis of randomized trialsEur J Pharmacol.(2019 Sep 5)
- Triglycerides - Roberts LJ 2nd, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JDThe relationship between dose of vitamin E and suppression of oxidative stress in humansFree Radic Biol Med.(2007 Nov 15)
- Triglycerides - No authors listedClofibrate and niacin in coronary heart diseaseJAMA.(1975 Jan 27)
- Cardiovascular Disease Mortality - Jasleen K. Duggal, Mukesh Singh, Navneet Attri, Param P. Singh, Neyaz Ahmed, Suneet Pahwa, Janos Molnar, Sarabjeet Singh, Sandeep Khosla, Rohit AroraEffect of Niacin Therapy on Cardiovascular Outcomes in Patients With Coronary Artery DiseaseJournal of Cardiovascular Pharmacology and Therapeutics.()
- Triglycerides - Riche DM, Riche KD, Blackshear CT, McEwen CL, Sherman JJ, Wofford MR, Griswold MEPterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trialEvid Based Complement Alternat Med.(2014)
- Triglycerides - Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
- Triglycerides - Chou EJ, Keevil JG, Aeschlimann S, Wiebe DA, Folts JD, Stein JHEffect of ingestion of purple grape juice on endothelial function in patients with coronary heart diseaseAm J Cardiol.(2001 Sep 1)
- Triglycerides - Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JEThe antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery diseaseArterioscler Thromb Vasc Biol.(2004 Nov)
- Triglycerides - L Axelrod, J Camuso, E Williams, K Kleinman, E Briones, D SchoenfeldEffects of a Small Quantity of omega-3 Fatty Acids on Cardiovascular Risk Factors in NIDDM. A Randomized, Prospective, Double-Blind, Controlled StudyDiabetes Care.(1994 Jan)
- C-Reactive Protein (CRP) - Geelen A, Brouwer IA, Schouten EG, Kluft C, Katan MB, Zock PLIntake of n-3 fatty acids from fish does not lower serum concentrations of C-reactive protein in healthy subjectsEur J Clin Nutr.(2004 Oct)
- Platelet Aggregation - Serebruany VL, Miller M, Pokov AN, Lynch D, Jensen JK, Hallén J, Atar DEarly impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemiaCardiology.(2011)
- Kidney Function - Tarec K Elajami, Abdulhamied Alfaddagh, Dharshan Lakshminarayan, Michael Soliman, Madhuri Chandnani, Francine K WeltyEicosapentaenoic and Docosahexaenoic Acids Attenuate Progression of Albuminuria in Patients With Type 2 Diabetes Mellitus and Coronary Artery DiseaseJ Am Heart Assoc.(2017 Jul 14)
- Atrial Fibrillation Incidence - Ali Vasheghani Farahani, Awat Yousefi Azar, Hamid Reza Goodarzynejad, Elnaz Khorrami, Mohammad Javad Hosseinzadeh-Attar, Sima Oshnouei, Alireza Alizadeh Ghavidel, Elham Golfeshan, Fateme Ghourban PourFish oil supplementation for primary prevention of atrial fibrillation after coronary artery bypass graft surgery: A randomized clinical trialInt J Surg.(2017 Jun)
- Triglycerides - Yang L, Zhu W, Zhang X, Zhou X, Wu W, Shen TEfficacy and safety of berberine for several cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials.Phytomedicine.(2023-Apr)
- Triglycerides - Sabet HR, Ahmadi M, Akrami M, Motamed M, Keshavarzian O, Abdollahi M, Rezaei M, Akbari HEffects of flaxseed supplementation on weight loss, lipid profiles, glucose, and high-sensitivity C-reactive protein in patients with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials.Clin Cardiol.(2024-Jan)
- TNF-Alpha - Askarpour M, Karimi M, Hadi A, Ghaedi E, Symonds ME, Miraghajani M, Javadian PEffect of flaxseed supplementation on markers of inflammation and endothelial function: A systematic review and meta-analysis.Cytokine.(2020 Feb)
- Total cholesterol - Schwab U, Alfthan G, Aro A, Uusitupa MLong-term effect of betaine on risk factors associated with the metabolic syndrome in healthy subjectsEur J Clin Nutr.(2011 Jan)
- Total cholesterol - Vittek JEffect of royal jelly on serum lipids in experimental animals and humans with atherosclerosisExperientia.(1995 Sep 29)
- Low-density lipoprotein (LDL) - Hamed MS, Gambert S, Bliden KP, Bailon O, Singla A, Antonino MJ, Hamed F, Tantry US, Gurbel PADark chocolate effect on platelet activity, C-reactive protein and lipid profile: a pilot studySouth Med J.(2008 Dec)
- Low-density lipoprotein (LDL) - Anne J Wanders, Ingeborg A Brouwer, Els Siebelink, Martijn B KatanEffect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjectsPLoS One.(2010 Feb 3)
- Oxidative Stress Biomarkers - Fitó M, Cladellas M, de la Torre R, Martí J, Alcántara M, Pujadas-Bastardes M, Marrugat J, Bruguera J, López-Sabater MC, Vila J, Covas MI; members of the SOLOS InvestigatorsAntioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trialAtherosclerosis.(2005 Jul)
- Oxidative Stress Biomarkers - Enseleit F, Sudano I, Périat D, Winnik S, Wolfrum M, Flammer AJ, Fröhlich GM, Kaiser P, Hirt A, Haile SR, Krasniqi N, Matter CM, Uhlenhut K, Högger P, Neidhart M, Lüscher TF, Ruschitzka F, Noll GEffects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over studyEur Heart J.(2012 Jul)
- C-Reactive Protein (CRP) - Binita Shah, Jonathan D Newman, Kathleen Woolf, Lisa Ganguzza, Yu Guo, Nicole Allen, Judy Zhong, Edward A Fisher, James SlaterAnti-Inflammatory Effects of a Vegan Diet Versus the American Heart Association-Recommended Diet in Coronary Artery Disease TrialJ Am Heart Assoc.(2018 Dec 4)
- Blood Pressure - Michael Macknin, Tammie Kong, Adam Weier, Sarah Worley, Anne S Tang, Naim Alkhouri, Mladen GolubicPlant-based, no-added-fat or American Heart Association diets: impact on cardiovascular risk in obese children with hypercholesterolemia and their parentsJ Pediatr.(2015 Apr)
- C-Reactive Protein (CRP) - Ali Reza Sobhani, Hossein Farshidi, Fariba Azarkish, Mahdiya Eslami, Ebrahim Eftekhar, Mansoor Keshavarz, Nepton SoltaniMagnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial StudyClin Pharmacol.(2020 Sep 25)
- C-Reactive Protein (CRP) - Rodríguez M, Ringstad L, Schäfer P, Just S, Hofer HW, Malmsten M, Siegel GReduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patientsAtherosclerosis.(2007 Jun)
- C-Reactive Protein (CRP) - Mayr HL, Tierney AC, Thomas CJ, Ruiz-Canela M, Radcliffe J, Itsiopoulos CMediterranean-type diets and inflammatory markers in patients with coronary heart disease: a systematic review and meta-analysis.Nutr Res.(2018-Feb)
- Left Ventricular Ejection Fraction - S Dwivedi, R JauhariBeneficial effects of Terminalia arjuna in coronary artery diseaseIndian Heart J.(Sep-Oct 1997)
- Heart Rate - Xin Yi, Yanli Zhou, Dingsheng Jiang, Xiaoyan Li, Yi Guo, Xuejun JiangEfficacy of folic acid supplementation on endothelial function and plasma homocysteine concentration in coronary artery disease: A meta-analysis of randomized controlled trialsExp Ther Med.(2014 May)
- ATP Regeneration - Omran H, Illien S, MacCarter D, St Cyr J, Lüderitz BD-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility studyEur J Heart Fail.(2003 Oct)
- Homocysteine - Korzun WJOral creatine supplements lower plasma homocysteine concentrations in humansClin Lab Sci.(2004 Spring)