Fibromyalgia (FM) is a syndrome characterized by widespread chronic musculoskeletal pain that lasts longer than 3 months, which can hinder daily activities like work and self-care. There are currently no standard treatments available for FM.
The main sign of fibromyalgia is chronic widespread pain, but people with the condition also experience a variety of symptoms including fatigue, sleep disturbances, cognitive dysfunction, migraines, anxiety or depression, digestive issues, and sensitivity to sensory stimuli.
Fibromyalgia is diagnosed through a comprehensive clinical evaluation by a healthcare provider because there are no specific tests for the condition. The diagnosis is considered a diagnosis of exclusion, meaning that other potential causes for the symptoms must be ruled out.
Fibromyalgia is treated with a combination of lifestyle changes, such as improving sleep and increasing physical activity, and pharmacological interventions, including antidepressants and muscle relaxants. Treatment should be personalized based on the individual's response to these approaches.
Some studies suggest that dietary changes may improve fibromyalgia symptoms, but the quality of these studies was poor and their dietary interventions were varied. Additional randomized controlled trials are necessary to clarify the relationship between diet and fibromyalgia.
Dietary supplements, particularly vitamin D and coenzyme Q10, have been studied for fibromyalgia, but the research findings are inconsistent, and more evidence is needed before making recommendations. There are currently no standard treatments for fibromyalgia, which has led to the use of these supplements to alleviate symptoms.
If initial therapies for fibromyalgia are ineffective, individuals may consider alternative treatments such as massage, chiropractic, and acupuncture, though evidence for these options is limited. It is advisable to consult a healthcare professional before trying any alternative treatments.
The cause of fibromyalgia is unknown, but current research indicates that both environmental and genetic factors may contribute to its development. Further research is necessary to draw definitive conclusions.
- ^Rosalba Siracusa, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela ImpellizzeriFibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options UpdateInt J Mol Sci.(2021 Apr 9)
- ^Daniel J ClauwFibromyalgia: a clinical reviewJAMA.(2014 Apr 16)
- ^The content of this page was partially adapted from MedlinePlus of the National Library of Medicine
- ^Laura Tomaino, Lluís Serra-Majem, Stefania Martini, Maria Rosaria Ingenito, Paola Rossi, Carlo La Vecchia, Fabrizia Bamonti, Luisella VignaFibromyalgia and Nutrition: An Updated ReviewJ Am Coll Nutr.(Sep-Oct 2021)
- ^Giuditta Pagliai, Ilaria Giangrandi, Monica Dinu, Francesco Sofi, Barbara ColombiniNutritional Interventions in the Management of Fibromyalgia SyndromeNutrients.(2020 Aug 20)
- ^Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, Russell AS, Russell IJ, Walitt B2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria.Semin Arthritis Rheum.(2016-12)
- ^Arnold LM, Bennett RM, Crofford LJ, Dean LE, Clauw DJ, Goldenberg DL, Fitzcharles MA, Paiva ES, Staud R, Sarzi-Puttini P, Buskila D, Macfarlane GJAAPT Diagnostic Criteria for Fibromyalgia.J Pain.(2019-06)
- ^Sarzi-Puttini P, Giorgi V, Marotto D, Atzeni FFibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment.Nat Rev Rheumatol.(2020-11)
- ^O'Brien AT, Deitos A, Triñanes Pego Y, Fregni F, Carrillo-de-la-Peña MTDefective Endogenous Pain Modulation in Fibromyalgia: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation Paradigms.J Pain.(2018-08)
- ^Harris RE, Sundgren PC, Craig AD, Kirshenbaum E, Sen A, Napadow V, Clauw DJElevated insular glutamate in fibromyalgia is associated with experimental pain.Arthritis Rheum.(2009-Oct)
- ^Foerster BR, Petrou M, Edden RA, Sundgren PC, Schmidt-Wilcke T, Lowe SE, Harte SE, Clauw DJ, Harris REReduced insular γ-aminobutyric acid in fibromyalgia.Arthritis Rheum.(2012-Feb)
- Fibromyalgia Symptoms - Elísabet Alcocer-Gómez, Jose Antonio Sánchez-Alcázar, Mario D CorderoCoenzyme q10 regulates serotonin levels and depressive symptoms in fibromyalgia patients: results of a small clinical trialJ Clin Psychopharmacol.(2014 Apr)
- Fibromyalgia Symptoms - Mario D Cordero, Elísabet Alcocer-Gómez, Manuel de Miguel, Ognjen Culic, Angel M Carrión, José Miguel Alvarez-Suarez, Pedro Bullón, Maurizio Battino, Ana Fernández-Rodríguez, José Antonio Sánchez-AlcazarCan coenzyme q10 improve clinical and molecular parameters in fibromyalgia?Antioxid Redox Signal.(2013 Oct 20)
- Fibromyalgia Symptoms - Sawaddiruk P, Apaijai N, Paiboonworachat S, Kaewchur T, Kasitanon N, Jaiwongkam T, Kerdphoo S, Chattipakorn N, Chattipakorn SCCoenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunctionFree Radic Res.(2019 Aug)
- Fibromyalgia Symptoms - Miyamae T, Seki M, Naga T, Uchino S, Asazuma H, Yoshida T, Iizuka Y, Kikuchi M, Imagawa T, Natsumeda Y, Yokota S, Yamamoto YIncreased oxidative stress and coenzyme Q10 deficiency in juvenile fibromyalgia: amelioration of hypercholesterolemia and fatigue by ubiquinol-10 supplementationRedox Rep.(2013)
- Fibromyalgia Symptoms - Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JAOxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvementPLoS One.(2012)
- Fibromyalgia Symptoms - Christiano R R Alves, Bianca M Santiago, Fernanda R Lima, Maria C G Otaduy, Ana Luisa Calich, Aline C C Tritto, Ana Lúcia de Sá Pinto, Hamilton Roschel, Cláudia C Leite, Fabiana B Benatti, Eloisa Bonfá, Bruno GualanoCreatine supplementation in fibromyalgia: a randomized, double-blind, placebo-controlled trialArthritis Care Res (Hoboken).(2013 Sep)
- Fibromyalgia Symptoms - Avi Leader, Daniella Amital, Alan Rubinow, Howard AmitalAn open-label study adding creatine monohydrate to ongoing medical regimens in patients with the fibromyalgia syndromeAnn N Y Acad Sci.(2009 Sep)
- Fibromyalgia Symptoms - K Kaartinen, K Lammi, M Hypen, M Nenonen, O Hanninen, A L RaumaVegan diet alleviates fibromyalgia symptomsScand J Rheumatol.(2000)
- Fibromyalgia Symptoms - Carolina Chaves, Paulo Cesar T Bittencourt, Andreia PelegriniIngestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialPain Med.(2020 Oct 1)
- Fibromyalgia Symptoms - Tine van de Donk, Marieke Niesters, Mikael A Kowal, Erik Olofsen, Albert Dahan, Monique van VelzenAn experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgiaPain.(2019 Apr)
- Pain - Martín-Sánchez E, Furukawa TA, Taylor J, Martin JLSystematic review and meta-analysis of cannabis treatment for chronic painPain Med.(2009 Nov)
- Myotonia Symptoms - Federica Montagnese, Kristina Stahl, Stephan Wenninger, Benedikt SchoserA role for cannabinoids in the treatment of myotonia? Report of compassionate use in a small cohort of patientsJ Neurol.(2020 Feb)
- Fibromyalgia Symptoms - Jacob E Teitelbaum, Clarence Johnson, John St CyrThe use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot studyJ Altern Complement Med.(2006 Nov)
- Fibromyalgia Symptoms - Merchant RE, Carmack CA, Wise CMNutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot studyPhytother Res.(2000 May)
- Fibromyalgia Symptoms - Jacobsen S, Danneskiold-Samsøe B, Andersen RBOral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluationScand J Rheumatol.(1991)
- Fibromyalgia Symptoms - Florian Wepner, Raphael Scheuer, Birgit Schuetz-Wieser, Peter Machacek, Elisabeth Pieler-Bruha, Heide S Cross, Julia Hahne, Martin FriedrichEffects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trialPain.(2014 Feb)
- Fibromyalgia Symptoms - Atalay Dogru, Ayse Balkarli, Veli Cobankara, Sevket Ercan Tunc, Mehmet SahinEffects of Vitamin D Therapy on Quality of Life in Patients with FibromyalgiaEurasian J Med.(2017 Jun)
- Fibromyalgia Symptoms - J F de Carvalho, F A G da Rocha Araújo, L M A da Mota, R B Aires, R P de AraujoVitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary ResultsIsr Med Assoc J.(2018 Jun)
- Fibromyalgia Symptoms - Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami SDouble-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patientsClin Exp Rheumatol.(2007 Mar-Apr)
- Fibromyalgia Symptoms - Axel Finckh, Isabelle Carey Berner, Bérengère Aubry-Rozier, Alexander Kai-Lik SoA randomized controlled trial of dehydroepiandrosterone in postmenopausal women with fibromyalgiaJ Rheumatol.(2005 Jul)
- Fibromyalgia Symptoms - Ana Paula Marum, Cátia Moreira, Fernando Saraiva, Pablo Tomas-Carus, Catarina Sousa-GuerreiroA low fermentable oligo-di-mono saccharides and polyols (FODMAP) diet reduced pain and improved daily life in fibromyalgia patientsScand J Pain.(2016 Oct)
- Fibromyalgia Symptoms - Selda Bagis, Mehmet Karabiber, Ismet As, Lülüfer Tamer, Canan Erdogan, Ayçe AtalayIs magnesium citrate treatment effective on pain, clinical parameters and functional status in patients with fibromyalgia?Rheumatol Int.(2013 Jan)
- Quality of Life - Macian N, Dualé C, Voute M, Leray V, Courrent M, Bodé P, Giron F, Sonneville S, Bernard L, Joanny F, Menard K, Ducheix G, Pereira B, Pickering GShort-Term Magnesium Therapy Alleviates Moderate Stress in Patients with Fibromyalgia: A Randomized Double-Blind Clinical Trial.Nutrients.(2022-May-17)
- Fibromyalgia Symptoms - Chad S Boomershine, Todd A Koch, David MorrisA Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with FibromyalgiaRheumatol Ther.(2018 Jun)
- Fibromyalgia Symptoms - Mansoor Shakiba, Ehsan Moazen-Zadeh, Ahmad Ali Noorbala, Morteza Jafarinia, Parisa Divsalar, Ladan Kashani, Nazila Shahmansouri, Abbas Tafakhori, Hannaneh Bayat, Shahin AkhondzadehSaffron ( Crocus sativus) versus duloxetine for treatment of patients with fibromyalgia: A randomized double-blind clinical trialAvicenna J Phytomed.(Nov-Dec 2018)
- Fibromyalgia Symptoms - Yeh SW, Hong CH, Shih MC, Tam KW, Huang YH, Kuan YCLow-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis.Pain Physician.(2019-May)
- Fibromyalgia Symptoms - Şevgin Ö, Buğday B, Aydoğan Baykara R, Günendi G, Akkurt B, Atasoy H, Dikmen Hoşbaş B, Akkurt MF, Karamancıoğlu BEfficacy of different exercises in women with fibromyalgia syndrome: a randomised controlled trial.Clin Exp Rheumatol.(2025 Feb 12)
- Fibromyalgia Symptoms - Caballol Angelats R, Gonçalves AQ, Abellana R, Carrasco-Querol N, Pàmies Corts A, González Serra G, Gràcia Benaiges D, Sancho Sol MC, Fusté Anguera I, Chavarria Jordana S, Cuevas Baticón B, Batlle Escolies G, Fibla Reverté M, Espuny Vallés N, Buera Pitarque N, Martí Cavallé M, Suazo NP, Estivill Bargalló J, López Guerrero MÀ, López Guerrero C, Pérez Acín P, Matamoros Callarisa I, Baucells J, Suazo Ciurana A, Fernández-Sáez J, Dalmau Llorca MR, Berenguera A, Aguilar Martín CEffectiveness of a Multicomponent Program for Fibromyalgia Patients in a Primary Care Setting (FIBROCARE Program): A Pragmatic Randomized Controlled Trial.J Clin Med.(2024 Dec 30)
- Pain - Donna D ZampiEfficacy of Theta Binaural Beats for the Treatment of Chronic PainAltern Ther Health Med.(Jan-Feb 2016)