Primary Dysmenorrhea (Menstrual Cramps)

Last Updated: October 13, 2024

Routine menstrual cramps are clinically called primary dysmenorrhea. Primary dysmenorrhea is menstrual pain not caused by other underlying conditions or diseases. If there is an underlying condition, such as endometriosis, that diagnosis is referred to as secondary dysmenorrhea.

Primary Dysmenorrhea (Menstrual Cramps) falls under theWomen’s Healthcategory.

What are menstrual cramps?

Menstrual cramps, known medically as primary dysmenorrhea, refer to menstrual pain that occurs without any underlying disease and is more prevalent in younger individuals. Approximately two-thirds of young women worldwide experience these cramps, which typically decrease with age.

What are the main signs and symptoms of menstrual cramps?

Menstrual cramps typically start a few days before menstruation and can last for several days afterward; they occur as sharp abdominal pain that may radiate to the back and legs. Additional symptoms can include nausea, sweating, headaches, dizziness, fatigue, and diarrhea.

How are menstrual cramps diagnosed?

Menstrual cramps are diagnosed through a focused medical history and a routine pelvic exam that typically reveals no abnormal findings. If secondary causes like endometriosis are suspected, further evaluation such as ultrasound may be necessary.

What are some of the main medical treatments for menstrual cramps?

The main medical treatments for menstrual cramps include over-the-counter nonsteroidal anti-inflammatory drugs (which reduce prostaglandin production and alleviate cramping) and occasionally oral contraceptive pills for significant primary dysmenorrhea. It's important to seek medical help if pain persists despite treatment or if there are concerning symptoms.

Have any supplements been studied for menstrual cramps?

Several supplements have been studied for treatment of menstrual cramps, including cinnamon, ginger, chamomile, fennel, omega-3 fatty acids, fish oil, vitamin D, vitamin E, calcium, magnesium, zinc, and boron.

How could diet affect menstrual cramps?

Diet can influence menstrual cramps, and dieting to lose weight, skipping meals, and low antioxidant intake are associated with a higher risk, whereas higher consumption of fiber, fruits, vegetables, and dairy is associated with a reduced risk. However, the variability in studies of dietary assessment and menstrual pain measurement indicates that more research is needed to establish specific dietary recommendations for dysmenorrhea.

Are there any other treatments for menstrual cramps?

Self-care practices such as applying heat to the lower abdomen, exercising, taking hot baths, and engaging in yoga or meditation may help alleviate menstrual cramps.

What causes menstrual cramps?

Menstrual cramps are primarily caused by elevated prostaglandin levels that occur due to a drop in progesterone before menstruation. There is also some uncertain evidence that elevated vasopressin concentrations may contribute to this condition.

Supplements Demystified: Get Our Unbiased, Evidence-Based Guide

Examine Database: Primary Dysmenorrhea (Menstrual Cramps)
What works and what doesn't?

Unlock the full potential of Examine

Get started

Don't miss out on the latest research

References
  1. ^Armour M, Parry K, Manohar N, Holmes K, Ferfolja T, Curry C, MacMillan F, Smith CAThe Prevalence and Academic Impact of Dysmenorrhea in 21,573 Young Women: A Systematic Review and Meta-AnalysisJ Womens Health (Larchmt).(2019 Aug)
  2. ^The content of this page was partially adapted from MedlinePlus of the National Library of Medicine
  3. ^A S CocoPrimary dysmenorrheaAm Fam Physician.(1999 Aug)
  4. ^Marjoribanks J, Ayeleke RO, Farquhar C, Proctor MNonsteroidal anti-inflammatory drugs for dysmenorrhoeaCochrane Database Syst Rev.(2015 Jul 30)
  5. ^Z Harel, F M Biro, R K Kottenhahn, S L RosenthalSupplementation with omega-3 polyunsaturated fatty acids in the management of dysmenorrhea in adolescentsAm J Obstet Gynecol.(1996 Apr)
  6. ^Maedeh Sharghi, Shabnam Malekpour Mansurkhani, Damoon Ashtary Larky, Wesam Kooti, Mehdi Niksefat, Mohammad Firoozbakht, Masoud Behzadifar, Milad Azami, Karo Servatyari, Leila JouybariAn update and systematic review on the treatment of primary dysmenorrheaJBRA Assist Reprod.(2019 Jan 31)
  7. ^Marzieh Saei Ghare Naz, Zahra Kiani, Farzaneh Rashidi Fakari, Vida Ghasemi, Masoumeh Abed, Giti OzgoliThe Effect of Micronutrients on Pain Management of Primary Dysmenorrhea: a Systematic Review and Meta-AnalysisJ Caring Sci.(2020 Mar 1)
  8. ^Zahra Bajalan, Zainab Alimoradi, Farnoosh MoafiNutrition as a Potential Factor of Primary Dysmenorrhea: A Systematic Review of Observational StudiesGynecol Obstet Invest.(2019)
  9. ^Zofia Barcikowska, Elżbieta Rajkowska-Labon, Magdalena Emilia Grzybowska, Rita Hansdorfer-Korzon, Katarzyna ZorenaInflammatory Markers in Dysmenorrhea and Therapeutic OptionsInt J Environ Res Public Health.(2020 Feb 13)
  10. ^Osayande AS, Mehulic SDiagnosis and initial management of dysmenorrheaAm Fam Physician.(2014 Mar 1)
  11. ^Armour M, Ee CC, Naidoo D, Ayati Z, Chalmers KJ, Steel KA, de Manincor MJ, Delshad EExercise for dysmenorrhoeaCochrane Database Syst Rev.(2019 Sep 20)
  12. ^Dawood MYPrimary dysmenorrhea: advances in pathogenesis and managementObstet Gynecol.(2006 Aug)
Examine Database References
  1. Dysmenorrhea Symptoms - Apay SE, Arslan S, Akpinar RB, Celebioglu AEffect of aromatherapy massage on dysmenorrhea in Turkish studentsPain Manag Nurs.(2012 Dec)
  2. Dysmenorrhea Symptoms - Ziaei S, Zakeri M, Kazemnejad AA randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoeaBJOG.(2005 Apr)
  3. Dysmenorrhea Symptoms - Kashanian M, Lakeh MM, Ghasemi A, Noori SEvaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrheaJ Reprod Med.(2013 Jan-Feb)
  4. Dysmenorrhea Symptoms - Ziaei S, Faghihzadeh S, Sohrabvand F, Lamyian M, Emamgholy TA randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoeaBJOG.(2001 Nov)
  5. Dysmenorrhea Symptoms - Nikkhah S, Dolatian M, Naghii MR, Zaeri F, Taheri SMEffects of boron supplementation on the severity and duration of pain in primary dysmenorrheaComplement Ther Clin Pract.(2015 May)
  6. Dysmenorrhea Symptoms - Ozgoli G, Goli M, Moattar FComparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrheaJ Altern Complement Med.(2009 Feb)
  7. PMS Symptoms - Khayat S, Kheirkhah M, Behboodi Moghadam Z, Fanaei H, Kasaeian A, Javadimehr MEffect of treatment with ginger on the severity of premenstrual syndrome symptomsISRN Obstet Gynecol.(2014 May 4)
  8. Dysmenorrhea Symptoms - Jenabi E, Fereidoony BEffect of Achillea Millefolium on Relief of Primary Dysmenorrhea: A Double-Blind Randomized Clinical Trial.J Pediatr Adolesc Gynecol.(2015-Oct)
  9. Cramps - Mirabi P, Namdari M, Alamolhoda S, Mojab FThe Effect of Melissa Officinalis Extract on the Severity of Primary DysmenorrhaIran J Pharm Res.(2017 Winter)
  10. Cramps - Bahrami A, Avan A, Sadeghnia HR, Esmaeili H, Tayefi M, Ghasemi F, Nejati Salehkhani F, Arabpour-Dahoue M, Rastgar-Moghadam A, Ferns GA, Bahrami-Taghanaki H, Ghayour-Mobarhan MHigh dose vitamin D supplementation can improve menstrual problems, dysmenorrhea, and premenstrual syndrome in adolescentsGynecol Endocrinol.(2018 Aug)
  11. Pelvic Pain - Zhou IW, Zhang AL, Tsang MS, Xue CCVitamin D for primary dysmenorrhea and endometriosis-related pain - A systematic review of registered RCTs.PLoS One.(2025)
  12. Pain - Mirabi P, Dolatian M, Mojab F, Majd HAEffects of valerian on the severity and systemic manifestations of dysmenorrheaInt J Gynaecol Obstet.(2011 Dec)
  13. Pain - Tsai IC, Hsu CW, Chang CH, Lei WT, Tseng PT, Chang KVComparative Effectiveness of Different Exercises for Reducing Pain Intensity in Primary Dysmenorrhea: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.Sports Med Open.(2024 May 30)
  14. Pain - Li X, Sun Y, Wang Y, Wang X, Yu CManual Therapy in Primary Dysmenorrhea: A Systematic Review and Meta-Analysis.J Pain Res.(2024)
  15. Pain - Rao A, Erickson J, Briskey DPalmitoylethanolamide (Levagen+) for acute menstrual pain: a randomized, crossover, double-blind, placebo-controlled trial.Women Health.(2025 Mar)
  16. PMS Symptoms - He Z, Chen R, Zhou Y, Geng L, Zhang Z, Chen S, Yao Y, Lu J, Lin STreatment for premenstrual syndrome with Vitex agnus castus: A prospective, randomized, multi-center placebo controlled study in ChinaMaturitas.(2009 May 20)
  17. PMS Symptoms - Masoumi SZ, Ataollahi M, Oshvandi KEffect of Combined Use of Calcium and Vitamin B6 on Premenstrual Syndrome Symptoms: a Randomized Clinical TrialJ Caring Sci.(2016 Mar 1)
  18. PMS Symptoms - Penland JG, Johnson PEDietary calcium and manganese effects on menstrual cycle symptomsAm J Obstet Gynecol.(1993 May)
  19. PMS Symptoms - Yonkers KA, Pearlstein TB, Gotman NA pilot study to compare fluoxetine, calcium, and placebo in the treatment of premenstrual syndromeJ Clin Psychopharmacol.(2013 Oct)
  20. PMS Symptoms - Sampalis F, Bunea R, Pelland MF, Kowalski O, Duguet N, Dupuis SEvaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrheaAltern Med Rev.(2003 May)
  21. PMS Symptoms - Tamborini A, Taurelle RValue of standardized Ginkgo biloba extract (EGb 761) in the management of congestive symptoms of premenstrual syndromeRev Fr Gynecol Obstet.(1993 Jul-Sep)
  22. Estrogen - Fukui H, Toyoshima K, Komaki RPsychological and neuroendocrinological effects of odor of saffron (Crocus sativus)Phytomedicine.(2011 Jun 15)