Raynaud's Phenomenon

Last Updated: November 11, 2024

Raynaud’s phenomenon is a disorder associated with vasoconstriction (blood vessel narrowing) in response to cold exposure or emotional stress.

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Raynaud's Phenomenon falls under theCardiovascular Healthcategory.

What is Raynaud’s phenomenon?

Raynaud's phenomenon is a condition in which blood flow to the skin is restricted in response to cold or emotional stress, and it primarily affects the fingers and toes. It can be classified as primary, without an underlying cause, or secondary, due to complications from another condition.

What are the main signs and symptoms of Raynaud’s phenomenon?

Raynaud's phenomenon is characterized by episodes in which blood vessels constrict, which lead to reduced blood flow and symptoms such as pain, numbness, and tingling, primarily in the fingers and toes. During an attack, the affected areas may turn pale, blue, and then red as circulation returns, and severe cases can result in ulcers or sores.

How is Raynaud’s phenomenon diagnosed?

Raynaud's phenomenon is diagnosed by evaluating risk factors and symptom frequency/severity and reviewing the individual's health history for signs of secondary Raynaud's. Additionally, nailfold capillary microscopy may be used to identify structural changes in capillaries that suggest underlying conditions.

What are some of the main medical treatments for Raynaud’s phenomenon?

The main medical treatments for Raynaud's phenomenon aim to reduce the severity and frequency of attacks while improving blood flow, starting with conservative lifestyle changes. If these are ineffective, medications such as alpha-receptor blockers, phosphodiesterase inhibitors, calcium-channel blockers, endothelin-1 inhibitors, and selective serotonin reuptake inhibitors (SSRIs) may be prescribed.

Have any supplements been studied for Raynaud’s phenomenon?

Several supplements have been studied for Raynaud's phenomenon — including pycnogenol, fish oil, essential fatty acids, and beetroot juice — and have shown improvements in blood flow and symptoms. However, L-arginine and N-acetylcystine did not demonstrate benefits in enhancing blood flow for individuals with Raynaud's.

How could diet affect Raynaud’s phenomenon?

There is limited research on the effect of diet on Raynaud's phenomenon, but some studies suggest that circulation-improving foods like garlic may enhance blood flow. Conversely, it is recommended to avoid caffeine-containing foods because they can reduce blood flow to the extremities.

Are there any other treatments for Raynaud’s phenomenon?

Alternative treatments for Raynaud's phenomenon include nonpharmaceutical interventions such as exercise, therapeutic gloves, laser therapy, and acupuncture, which may provide modest benefits. Additionally, a study suggested that alternating between warm water immersion and cold exposure could help increase finger temperatures by training the body's vascular responses.

What causes Raynaud’s phenomenon?

Raynaud's phenomenon is primarily caused by overactivation of the sympathetic nervous system; it leads to increased norepinephrine release and subsequent vasoconstriction, which reduces blood flow to the extremities. There are 2 variants: primary Raynaud's occurs independently, and secondary Raynaud's is associated with underlying conditions like lupus or scleroderma.

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Update History
2024-11-11 00:30:05

All new FAQs were added to this page.

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We added all new FAQs to this page including:

What is Raynaud’s phenomenon?: A new FAQ was added describing Raynaud’s phenomenon (also called Raynaud’s disorder or Raynaud’s Syndrome). This disorder causes blood vessels in the extremities to inappropriately constrict in response to stress or cold temperatures.  The differences between the different types of Raynaud’s were also discussed. Since secondary Raynaud’s is caused by the presence of another underlying (generally autoimmune) condition, distinguishing between primary and secondary Raynaud’s is important to determine the appropriate treatments.   What are the main signs and symptoms of Raynaud’s phenomenon?: A new FAQ was added that discusses the signs and symptoms of Raynaud’s attacks (also called episodes), and the primary areas of the body that are affected.

How is Raynaud’s phenomenon diagnosed?: A new FAQ was added that discusses diagnostic considerations that health care providers use when Raynaud’s is suspected. Factors health care providers may consider when distinguishing primary vs. secondary Raynaud’s were also noted, including nailfold capillary microscopy (NCM). NCM is a procedure that allows physicians to see changes in the structure of small blood vessels and is an important tool for distinguishing between primary and secondary Raynaud’s.   What are some of the main medical treatments for Raynaud’s?: A new FAQ was added to discuss the main medical treatments for Raynaud’s, which typically are conservative and aimed at limiting or avoiding the conditions that instigate attacks. Differences in treatment strategies for primary vs. secondary Raynaud’s were also discussed, as well as some of the common pharmaceutical treatments.

Have any supplements been studied for Raynaud’s phenomenon?: A new FAQ  was added discussing supplements that have been studied for treating Raynaud’s. Studies have tended to be less rigorous, smaller-scale pilot trials, resulting in some uncertainty in the results.   How could diet affect Raynaud’s phenomenon?: A new FAQ was added discussing diet interventions for Raynaud’s. Although there have not been many studies (or any) testing diet interventions for Raynaud’s some investigators have speculated that foods with circulation-promoting properties may be helpful.   Are there any other treatments for Raynaud’s phenomenon?: A new FAQ was added discussing alternative, non-pharmaceutical treatments for Raynaud’s. Theoretically, interventions that affect the smooth muscle tissue regulating blood vessel narrowing (vasoconstriction) and widening (vasodilation) could help to recalibrate the signaling mechanisms that trigger inappropriate vasoconstriction in people with Raynaud’s, as suggested in a study in the early 1980s testing the effect of finger immersion in warm water followed by cold exposure in people with Raynaud’s.   What causes Raynaud’s phenomenon?: An FAQ was added discussing the mechanisms that trigger Raynaud’s attacks. Raynaud’s is an over-reaction of the sympathetic nervous system, which causes blood vessels in the extremities (fingers and toes but sometimes other parts of the body as well) to constrict inappropriately, cutting off blood flow and leading to low oxygen levels in the affected digits and the characteristic color-change. 

We added three randomized controlled trials and one meta-analysis to the Examine Database.

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References
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Examine Database References
  1. Raynaud's Phenomenon Symptoms - Bredie SJ, Jong MCNo significant effect of ginkgo biloba special extract EGb 761 in the treatment of primary Raynaud phenomenon: a randomized controlled trialJ Cardiovasc Pharmacol.(2012 Mar)
  2. Raynaud's Phenomenon Symptoms - Choi WS, Choi CJ, Kim KS, Lee JH, Song CH, Chung JH, Ock SM, Lee JB, Kim CMTo compare the efficacy and safety of nifedipine sustained release with Ginkgo biloba extract to treat patients with primary Raynaud's phenomenon in South Korea; Korean Raynaud study (KOARA study)Clin Rheumatol.(2009 May)
  3. Raynaud's Phenomenon Symptoms - DiGiacomo RA, Kremer JM, Shah DMFish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study.Am J Med.(1989 Feb)
  4. Raynaud's Phenomenon Symptoms - Zhou F, Huang E, Zheng E, Deng JThe use of acupuncture in patients with Raynaud's syndrome: a systematic review and meta-analysis of randomized controlled trials.Acupunct Med.(2023 Apr)
  5. Endothelial Function - Shepherd AI, Costello JT, Bailey SJ, Bishop N, Wadley AJ, Young-Min S, Gilchrist M, Mayes H, White D, Gorczynski P, Saynor ZL, Massey H, Eglin CM"Beet" the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud's phenomenon.J Appl Physiol (1985).(2019 Nov 1)