Type 2 Diabetes

Last Updated: July 14, 2023

Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It is characterized by insulin resistance in muscle, fat, and pancreas cells and an inability of the pancreas to manufacture enough insulin to control blood glucose levels. T2D is strongly associated with excess body fat, and weight loss induced by lifestyle changes is extremely effective for treating T2D.

Type 2 Diabetes falls under theDiabetes & Blood SugarandHealthy Aging & Longevitycategories.

What is type 2 diabetes?

Type 2 diabetes (T2D) is a disease in which blood glucose levels are too high. It typically starts with insulin resistance: a condition where cells don’t respond appropriately to insulin. The pancreas then produces more insulin to try and get the cells to respond, but it’s unable to sustain this heightened production over time, resulting in chronically high blood glucose levels.

What are the main signs and symptoms of type 2 diabetes?

Most people with T2D do not present with symptoms initially because symptoms develop slowly over several years. People who do present with symptoms may report increased thirst, urination, or hunger, fatigue, blurred vision, and/or numbness or tingling in the feet or hands.

How is type 2 diabetes diagnosed?

There are three blood tests used to diagnose T2D: fasting plasma glucose, 2-hour plasma glucose during a 75-gram oral glucose tolerance test, and HbA1c (i.e., average plasma glucose levels over the past 3 months).[1]

What are some of the main medical treatments for type 2 diabetes?

Initial pharmacotherapy generally starts with metformin, which is an older, safe and relatively inexpensive drug. Frequently, other medications are required to control glucose levels, such as sodium-glucose cotransporter-2 (SGLT2) inhibitors or glucagon-like peptide 1 receptor agonists (GLP-1 RA). These medications can be particularly beneficial in people at an increased risk of or with established cardiovascular or kidney disease.[2] Up to 35% of people with T2D eventually require insulin to achieve their glycemic targets. Besides glucose-lowering medications, medications or procedures (i.e., metabolic surgery) that facilitate weight loss are also effective for improving glycemic control.

Have any supplements been studied for type 2 diabetes?

The supplement with the most potential for improving glycemic control is berberine, an alkaloid extract from various plants used in traditional Chinese medicine.[3] Soluble fiber (e.g., psyllium) is another effective option.[4]

How could diet affect type 2 diabetes?

Long-term excess energy intake leads to the accumulation of fat in the liver and pancreas that causes T2D, and calorie restriction can decrease intra-organ fat and put the disease into remission.[5] There is some evidence that high intake of added fructose, in particular, raises the risk of T2D.[6] However, any dietary pattern can be effective for treating and preventing T2D as long as it facilitates an energy deficit and promotes sustained weight loss.[7]

Are there any other treatments for type 2 diabetes?

An increase in physical activity is recommended alongside dietary changes to achieve significant weight loss. A combination of aerobic and resistance exercise seems to be best to maximize improvements in glycemic control and health benefits.[8] In people with prediabetes, exercise and weight loss can reduce the risk of progression to T2D by 58%. Psychological interventions, like cognitive behavioral therapy and motivational interviewing, can also improve glycemic control.[9]

What causes type 2 diabetes?

The cause of T2D is multifactorial, based on genetic predisposition and environment. Obesity, inflammatory diet, and sedentary lifestyle all contribute to the risk of developing T2D. Abdominal obesity is a strong risk factor for T2D, and leads to the accumulation of more fat in the liver and pancreas than a person can tolerate, which results from long-term excess energy intake.[5]

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References
  1. ^American Diabetes Association Professional Practice Committee2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2022Diabetes Care.(2022 Jan 1)
  2. ^, Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, Green J, Huang E, Isaacs D, Kahan S, Leon J, Lyons SK, Peters AL, Prahalad P, Reusch JEB, Young-Hyman D9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes-2022.Diabetes Care.(2022-01-01)
  3. ^Jing Guo, Hongdong Chen, Xueqin Zhang, Wenjiao Lou, Pingna Zhang, Yuheng Qiu, Chao Zhang, Yaoxian Wang, Wei Jing LiuThe Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsOxid Med Cell Longev.(2021 Dec 15)
  4. ^Xie Y, Gou L, Peng M, Zheng J, Chen LEffects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Clin Nutr.(2021-04)
  5. ^Roy Taylor, Ambady Ramachandran, William S Yancy Jr, Nita G ForouhiNutritional basis of type 2 diabetes remissionBMJ.(2021 Jul 7)
  6. ^DiNicolantonio et alAdded Fructose A Principal Driver of Type 2 Diabetes Mellitus and Its Consequences(2015-01-29)
  7. ^Evert AB, Dennison M, Gardner CD, Garvey WT, Lau KHK, MacLeod J, Mitri J, Pereira RF, Rawlings K, Robinson S, Saslow L, Uelmen S, Urbanski PB, Yancy WS JrNutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus ReportDiabetes Care.(2019 May)
  8. ^Kanaley JA, Colberg SR, Corcoran MH, Malin SK, Rodriguez NR, Crespo CJ, Kirwan JP, Zierath JRExercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine.Med Sci Sports Exerc.(2022-02-01)
  9. ^Winkley K, Upsher R, Stahl D, Pollard D, Kasera A, Brennan A, Heller S, Ismail KPsychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.Health Technol Assess.(2020-06)
  10. ^Franz MJ, Boucher JL, Rutten-Ramos S, VanWormer JJLifestyle weight-loss intervention outcomes in overweight and obese adults with type 2 diabetes: a systematic review and meta-analysis of randomized clinical trialsJ Acad Nutr Diet.(2015 Sep)
  11. ^Wang X, Bao W, Liu J, Ouyang YY, Wang D, Rong S, Xiao X, Shan ZL, Zhang Y, Yao P, Liu LGInflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysisDiabetes Care.(2013 Jan)
  12. ^Li S, Shin HJ, Ding EL, van Dam RMAdiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysisJAMA.(2009 Jul 8)
  13. ^Greenfield JR, Campbell LVRelationship between inflammation, insulin resistance and type 2 diabetes: 'cause or effect'?Curr Diabetes Rev.(2006 May)
  14. ^Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, Federici M, Filippatos G, Grobbee DE, Hansen TB, Huikuri HV, Johansson I, Jüni P, Lettino M, Marx N, Mellbin LG, Östgren CJ, Rocca B, Roffi M, Sattar N, Seferović PM, Sousa-Uva M, Valensi P, Wheeler DC,2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD.Eur Heart J.(2020-01-07)
  15. ^American Diabetes Association Professional Practice Committee10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2022Diabetes Care.(2022 Jan 1)
  16. ^, Draznin B, Aroda VR, Bakris G, Benson G, Brown FM, Freeman R, Green J, Huang E, Isaacs D, Kahan S, Leon J, Lyons SK, Peters AL, Prahalad P, Reusch JEB, Young-Hyman D11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes-2022.Diabetes Care.(2022-01-01)
  17. ^Adams LA, Anstee QM, Tilg H, Targher GNon-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases.Gut.(2017-06)
  18. ^Taylor R, Al-Mrabeh A, Sattar NUnderstanding the mechanisms of reversal of type 2 diabetes.Lancet Diabetes Endocrinol.(2019-09)
  19. ^Thomas DRSarcopeniaClin Geriatr Med.(2010 May)
  20. ^Sundell JResistance Training Is an Effective Tool against Metabolic and Frailty SyndromesAdv Prev Med.(2011)
  21. ^Johnston AP, De Lisio M, Parise GResistance training, sarcopenia, and the mitochondrial theory of agingAppl Physiol Nutr Metab.(2008 Feb)
  22. ^Pillard F, Laoudj-Chenivesse D, Carnac G, Mercier J, Rami J, Rivière D, Rolland YPhysical activity and sarcopeniaClin Geriatr Med.(2011 Aug)
  23. ^Bautmans I, Van Puyvelde K, Mets TSarcopenia and functional decline: pathophysiology, prevention and therapyActa Clin Belg.(2009 Jul-Aug)
  24. ^Kemmler W, von Stengel S, Engelke K, Häberle L, Kalender WAExercise effects on bone mineral density, falls, coronary risk factors, and health care costs in older women: the randomized controlled senior fitness and prevention (SEFIP) studyArch Intern Med.(2010 Jan 25)
  25. ^Taaffe DR, Robinson TL, Snow CM, Marcus RHigh-impact exercise promotes bone gain in well-trained female athletesJ Bone Miner Res.(1997 Feb)
  26. ^Martyn-St James M, Carroll SEffects of different impact exercise modalities on bone mineral density in premenopausal women: a meta-analysisJ Bone Miner Metab.(2010 May)
  27. ^Hourigan SR, Nitz JC, Brauer SG, O'Neill S, Wong J, Richardson CAPositive effects of exercise on falls and fracture risk in osteopenic womenOsteoporos Int.(2008 Jul)
  28. ^Kronhed AC, Möller MEffects of physical exercise on bone mass, balance skill and aerobic capacity in women and men with low bone mineral density, after one year of training--a prospective studyScand J Med Sci Sports.(1998 Oct)
  29. ^Asikainen TM, Kukkonen-Harjula K, Miilunpalo SExercise for health for early postmenopausal women: a systematic review of randomised controlled trialsSports Med.(2004)
  30. ^de Matos O, Lopes da Silva DJ, Martinez de Oliveira J, Castelo-Branco CEffect of specific exercise training on bone mineral density in women with postmenopausal osteopenia or osteoporosisGynecol Endocrinol.(2009 Sep)
  31. ^Yamazaki S, Ichimura S, Iwamoto J, Takeda T, Toyama YEffect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosisJ Bone Miner Metab.(2004)
  32. ^Wilks DC, Winwood K, Gilliver SF, Kwiet A, Chatfield M, Michaelis I, Sun LW, Ferretti JL, Sargeant AJ, Felsenberg D, Rittweger JBone mass and geometry of the tibia and the radius of master sprinters, middle and long distance runners, race-walkers and sedentary control participants: a pQCT studyBone.(2009 Jul)
  33. ^Kontulainen S, Sievänen H, Kannus P, Pasanen M, Vuori IEffect of long-term impact-loading on mass, size, and estimated strength of humerus and radius of female racquet-sports players: a peripheral quantitative computed tomography study between young and old starters and controlsJ Bone Miner Res.(2003 Feb)
  34. ^Derman O, Cinemre A, Kanbur N, Doğan M, Kiliç M, Karaduman EEffect of swimming on bone metabolism in adolescentsTurk J Pediatr.(2008 Mar-Apr)
  35. ^Taaffe DR, Snow-Harter C, Connolly DA, Robinson TL, Brown MD, Marcus RDifferential effects of swimming versus weight-bearing activity on bone mineral status of eumenorrheic athletesJ Bone Miner Res.(1995 Apr)
  36. ^A Prospective Study of Weight Training and Risk of Type 2 Diabetes Mellitus in Men
  37. ^Meshkani R, Adeli KHepatic insulin resistance, metabolic syndrome and cardiovascular diseaseClin Biochem.(2009 Sep)
  38. ^Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve BRecent advances in the relationship between obesity, inflammation, and insulin resistanceEur Cytokine Netw.(2006 Mar)
  39. ^Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DLMechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similaritiesDiabetes.(2005 Dec)
  40. ^Akirav E, Kushner JA, Herold KCBeta-cell mass and type 1 diabetes: going, going, goneDiabetes.(2008 Nov)
  41. ^Stecenko AA, Moran AUpdate on cystic fibrosis-related diabetesCurr Opin Pulm Med.(2010 Nov)
  42. ^Short KR, Vittone JL, Bigelow ML, Proctor DN, Rizza RA, Coenen-Schimke JM, Nair KSImpact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacityDiabetes.(2003 Aug)
  43. ^Karakelides H, Irving BA, Short KR, O'Brien P, Nair KSAge, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial functionDiabetes.(2010 Jan)
  44. ^Finucane FM, Sharp SJ, Purslow LR, Horton K, Horton J, Savage DB, Brage S, Besson H, De Lucia Rolfe E, Sleigh A, Martin HJ, Aihie Sayer A, Cooper C, Ekelund U, Griffin SJ, Wareham NJThe effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trialDiabetologia.(2010 Apr)
  45. ^van der Heijden GJ, Toffolo G, Manesso E, Sauer PJ, Sunehag ALAerobic exercise increases peripheral and hepatic insulin sensitivity in sedentary adolescentsJ Clin Endocrinol Metab.(2009 Nov)
  46. ^Goulet ED, Mélançon MO, Aubertin-Leheudre M, Dionne IJAerobic training improves insulin sensitivity 72-120 h after the last exercise session in younger but not in older womenEur J Appl Physiol.(2005 Oct)
  47. ^Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA, Schuster DPShort-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivityJ Clin Endocrinol Metab.(2008 Mar)
  48. ^Krogh-Madsen R, Thyfault JP, Broholm C, Mortensen OH, Olsen RH, Mounier R, Plomgaard P, van Hall G, Booth FW, Pedersen BKA 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivityJ Appl Physiol.(2010 May)
  49. ^Fisher G, Hunter GR, Gower BAAerobic exercise training conserves insulin sensitivity for 1 yr following weight loss in overweight womenJ Appl Physiol.(2012 Feb)
  50. ^Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, Chrousos GP, Sidossis LSAerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girlsMetabolism.(2005 Nov)
  51. ^Carr DB, Utzschneider KM, Boyko EJ, Asberry PJ, Hull RL, Kodama K, Callahan HS, Matthys CC, Leonetti DL, Schwartz RS, Kahn SE, Fujimoto WYA reduced-fat diet and aerobic exercise in Japanese Americans with impaired glucose tolerance decreases intra-abdominal fat and improves insulin sensitivity but not beta-cell functionDiabetes.(2005 Feb)
  52. ^van der Heijden GJ, Wang ZJ, Chu ZD, Sauer PJ, Haymond MW, Rodriguez LM, Sunehag ALA 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescentsObesity (Silver Spring).(2010 Feb)
  53. ^Van Der Heijden GJ, Wang ZJ, Chu Z, Toffolo G, Manesso E, Sauer PJ, Sunehag ALStrength exercise improves muscle mass and hepatic insulin sensitivity in obese youthMed Sci Sports Exerc.(2010 Nov)
  54. ^Black LE, Swan PD, Alvar BAEffects of intensity and volume on insulin sensitivity during acute bouts of resistance trainingJ Strength Cond Res.(2010 Apr)
Examine Database References
  1. Diabetic Neuropathy Symptoms - K K Kiew, W B Wan Mohamad, A Ridzuan, M MafauzyEffects of sulbutiamine on diabetic polyneuropathy: an open randomised controlled study in type 2 diabeticsMalays J Med Sci.(2002 Jan)
  2. Diabetic Neuropathy Symptoms - Dinesh Selvarajah, Rajiv Gandhi, Celia J Emery, Solomon TesfayeRandomized placebo-controlled double-blind clinical trial of cannabis-based medicinal product (Sativex) in painful diabetic neuropathy: depression is a major confounding factorDiabetes Care.(2010 Jan)
  3. Diabetic Neuropathy Symptoms - Mark S Wallace, Thomas D Marcotte, Anya Umlauf, Ben Gouaux, Joseph H AtkinsonEfficacy of Inhaled Cannabis on Painful Diabetic NeuropathyJ Pain.(2015 Jul)
  4. Diabetic Neuropathy Symptoms - Asadi S, Gholami MS, Siassi F, Qorbani M, Khamoshian K, Sotoudeh GNano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: A randomized double-blind placebo- controlled clinical trialComplement Ther Med.(2019 Apr)
  5. HbA1c - Adab Z, Eghtesadi S, Vafa MR, Heydari I, Shojaii A, Haqqani H, Arablou T, Eghtesadi MEffect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patientsPhytother Res.(2019 Apr)
  6. HbA1c - Maithili Karpaga Selvi N, Sridhar MG, Swaminathan RP, Sripradha REfficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic PatientsIndian J Clin Biochem.(2015 Apr)
  7. HbA1c - Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai SCurcumin extract for prevention of type 2 diabetesDiabetes Care.(2012 Nov)
  8. HbA1c - Na LX, Li Y, Pan HZ, Zhou XL, Sun DJ, Meng M, Li XX, Sun CHCurcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trialMol Nutr Food Res.(2013 Sep)
  9. HbA1c - Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, Sahebkar AEffects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled TrialDrug Res (Stuttg).(2018 Jul)
  10. HbA1c - Adibian M, Hodaei H, Nikpayam O, Sohrab G, Hekmatdoost A, Hedayati MThe effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trialPhytother Res.(2019 May)
  11. HbA1c - Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Ghayour Mobarhan M, Kazemi Oskuee RThe effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trialAvicenna J Phytomed.(2016 Sep-Oct)
  12. HbA1c - Chuengsamarn S, Rattanamongkolgul S, Phonrat B, Tungtrongchitr R, Jirawatnotai SReduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trialJ Nutr Biochem.(2014 Feb)
  13. Blood glucose - Yang H, Xu W, Zhou Z, Liu J, Li X, Chen L, Weng J, Yu ZCurcumin attenuates urinary excretion of albumin in type II diabetic patients with enhancing nuclear factor erythroid-derived 2-like 2 (Nrf2) system and repressing inflammatory signaling efficaciesExp Clin Endocrinol Diabetes.(2015 Jun)
  14. Weight - Panahi Y, Khalili N, Sahebi E, Namazi S, Reiner Ž, Majeed M, Sahebkar ACurcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trialComplement Ther Med.(2017 Aug)
  15. C-Reactive Protein (CRP) - Tabrizi R, Vakili S, Akbari M, Mirhosseini N, Lankarani KB, Rahimi M, Mobini M, Jafarnejad S, Vahedpoor Z, Asemi ZThe effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2019-Feb)
  16. Diabetic Neuropathy Symptoms - Sheyu Li, Xiang Chen, Qianrui Li, Juan Du, Zhimin Liu, Yongde Peng, Mian Xu, Qifu Li, Minxiang Lei, Changjiang Wang, Shaoxiong Zheng, Xiaojuan Zhang, Hongling Yu, Jinyu Shi, Shibing Tao, Ping Feng, Haoming TianEffects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trialJ Diabetes Investig.(2016 Sep)
  17. HbA1c - Y Liang, Y Li, J Shan, B Yu, Z HoThe effects of oral L-carnitine treatment on blood lipid metabolism and the body fat content in the diabetic patientAsia Pac J Clin Nutr.(1998 Jun)
  18. HbA1c - Giuseppe Derosa, Pamela Maffioli, Sibilla A T Salvadeo, Ilaria Ferrari, Alessia Gravina, Roberto Mereu, Angela D'Angelo, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroEffects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on inflammatory parameters in diabetic patientsMetabolism.(2011 Mar)
  19. HbA1c - Fabio Galvano, Giovanni Li Volti, Michele Malaguarnera, Teresio Avitabile, Tijana Antic, Marco Vacante, Mariano MalaguarneraEffects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitusExpert Opin Pharmacother.(2009 Aug)
  20. HbA1c - Mariano Malaguarnera, Marco Vacante, Teresio Avitabile, Marcella Malaguarnera, Lisa Cammalleri, Massimo MottaL-Carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetesAm J Clin Nutr.(2009 Jan)
  21. HbA1c - Aneliya Parvanova, Matias Trillini, Manuel A Podestà, Ilian P Iliev, Carolina Aparicio, Annalisa Perna, Francesco Peraro, Nadia Rubis, Flavio Gaspari, Antonio Cannata, Silvia Ferrari, Antonio C Bossi, Roberto Trevisan, Sreejith Parameswaran, Jonathan S Chávez-Iñiguez, Fahrudin Masnic, Sidy Mohamed Seck, Teerayuth Jiamjariyaporn, Monica Cortinovis, Luca Perico, Kanishka Sharma, Giuseppe Remuzzi, Piero Ruggenenti, David G WarnockBlood Pressure and Metabolic Effects of Acetyl-l-Carnitine in Type 2 Diabetes: DIABASI Randomized Controlled TrialJ Endocr Soc.(2018 Mar 22)
  22. HbA1c - Hadier M El-Sheikh, Sahar M El-Haggar, Tamer A ElbedewyComparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patientsDiabetes Metab Syndr.(Jan-Feb 2019)
  23. HbA1c - A R Rahbar, R Shakerhosseini, N Saadat, F Taleban, A Pordal, B GollestanEffect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitusEur J Clin Nutr.(2005 Apr)
  24. HbA1c - Giuseppe Derosa, Pamela Maffioli, Ilaria Ferrari, Angela D'Angelo, Elena Fogari, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G CiceroComparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patientsFundam Clin Pharmacol.(2011 Oct)
  25. HbA1c - Giuseppe Derosa, Arrigo F G Cicero, Antonio Gaddi, Amedeo Mugellini, Leonardina Ciccarelli, Roberto FogariThe effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitusClin Ther.(2003 May)
  26. HbA1c - Eun Shil Hong, Eun Ky Kim, Seon Mee Kang, Ah Reum Khang, Sung Hee Choi, Kyong Soo Park, Hak Chul Jang, Soo LimEffect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled studyJ Gastroenterol Hepatol.(2014)
  27. HbA1c - Alavinejad P, et alEvaluation of L-Carnitine Efficacy in the Treatment of Non-Alcoholic Fatty Liver Disease among Diabetic Patients: A Randomized Double Blind Pilot StudyJ Gastroenterol Hepatol.()
  28. HbA1c - Zamani M, Pahlavani N, Nikbaf-Shandiz M, Rasaei N, Ghaffarian-Ensaf R, Asbaghi O, Shiraseb F, Rastgoo SThe effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis.Front Nutr.(2022)
  29. Insulin - Molfino A, Cascino A, Conte C, Ramaccini C, Rossi Fanelli F, Laviano ACaloric restriction and L-carnitine administration improves insulin sensitivity in patients with impaired glucose metabolismJPEN J Parenter Enteral Nutr.(2010 May-Jun)
  30. Insulin - Li Y, Xie Y, Qiu C, Yu B, Yang F, Cheng Y, Zhong W, Yuan JEffects of L-carnitine supplementation on glucolipid metabolism: a systematic review and meta-analysis.Food Funct.(2023-Mar-06)
  31. Glycemic Control - González-Ortiz M, Hernández-González SO, Hernández-Salazar E, Martínez-Abundis EEffect of oral L-carnitine administration on insulin sensitivity and lipid profile in type 2 diabetes mellitus patientsAnn Nutr Metab.(2008)
  32. Apolipoprotein A - Ali Sheikhi, Kurosh Djafarian, Moein Askarpour, Sakineh Shab-BidarThe effects of supplementation with L-carnitine on apolipoproteins: A systematic review and meta-analysis of randomized trialsEur J Pharmacol.(2019 Sep 5)
  33. High-density lipoprotein (HDL) - Vincenzo Solfrizzi, Cristiano Capurso, Anna M Colacicco, Alessia D'Introno, Cristina Fontana, Sabrina A Capurso, Francesco Torres, Anna M Gadaleta, Aleardo Koverech, Antonio Capurso, Francesco PanzaEfficacy and tolerability of combined treatment with L-carnitine and simvastatin in lowering lipoprotein(a) serum levels in patients with type 2 diabetes mellitusAtherosclerosis.(2006 Oct)
  34. Erections - V Gentile, P Vicini, G Prigiotti, A Koverech, F Di SilverioPreliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetesCurr Med Res Opin.(2004 Sep)
  35. Whole Body Glucose Uptake - G Mingrone, A V Greco, E Capristo, G Benedetti, A Giancaterini, A De Gaetano, G GasbarriniL-carnitine improves glucose disposal in type 2 diabetic patientsJ Am Coll Nutr.(1999 Feb)
  36. HbA1c - Laura M Pompano, Erick BoyEffects of Dose and Duration of Zinc Interventions on Risk Factors for Type 2 Diabetes and Cardiovascular Disease: A Systematic Review and Meta-AnalysisAdv Nutr.(2020 Jul 28)
  37. HbA1c - Ghaedi K, Ghasempour D, Jowshan M, Zheng M, Ghobadi S, Jafari AEffect of zinc supplementation in the management of type 2 diabetes: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of randomized controlled trials.Crit Rev Food Sci Nutr.(2023-May-15)
  38. High-density lipoprotein (HDL) - Asbaghi O, Sadeghian M, Fouladvand F, Panahande B, Nasiri M, Khodadost M, Shokri A, Pirouzi A, Sadeghi OEffects of zinc supplementation on lipid profile in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Nutr Metab Cardiovasc Dis.(2020-Jul-24)
  39. LDL Oxidation - Blostein-Fujii A, DiSilvestro RA, Frid D, Katz C, Malarkey WShort-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitroAm J Clin Nutr.(1997 Sep)
  40. HbA1c - Michelle L Asp, Angela L Collene, Leigh E Norris, Rachel M Cole, Michael B Stout, Szu-Yu Tang, Jason C Hsu, Martha A BeluryTime-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crossover studyClin Nutr.(2011 Aug)
  41. Blood glucose - Moloney F, Yeow TP, Mullen A, Nolan JJ, Roche HMConjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitusAm J Clin Nutr.(2004 Oct)
  42. Weight - Leigh E Norris, Angela L Collene, Michelle L Asp, Jason C Hsu, Li-Fen Liu, Julia R Richardson, Dongmei Li, Doris Bell, Kwame Osei, Rebecca D Jackson, Martha A BeluryComparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitusAm J Clin Nutr.(2009 Sep)
  43. HbA1c - Løvås K, Røst TH, Skorve J, Ulvik RJ, Gudbrandsen OA, Bohov P, Wensaas AJ, Rustan AC, Berge RK, Husebye ESTetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidationDiabetes Obes Metab.(2009 Apr)
  44. HbA1c - Coleman MD, Fernandes S, Khanderia LA preliminary evaluation of a novel method to monitor a triple antioxidant combination (vitamins E, C and α-lipoic acid) in diabetic volunteers using in vitro methaemoglobin formationEnviron Toxicol Pharmacol.(2003 Jun)
  45. HbA1c - Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk AGlycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled studyAsia Pac J Clin Nutr.(2012)
  46. Glycemic Control - de Oliveira AM, Rondó PH, Luzia LA, D'Abronzo FH, Illison VKThe effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trialDiabetes Res Clin Pract.(2011 May)
  47. Oxidative Stress Biomarkers - P Palacka, J Kucharska, J Murin, K Dostalova, A Okkelova, M Cizova, I Waczulikova, S Moricova, A GvozdjakovaComplementary therapy in diabetic patients with chronic complications: a pilot studyBratisl Lek Listy.(2010)
  48. HbA1c - Siavash M, Amini MVitamin C may have similar beneficial effects to Gemfibrozil on serum high-density lipoprotein-cholesterol in type 2 diabetic patientsJ Res Pharm Pract.(2014 Jul)
  49. HbA1c - Bishop N, Schorah CJ, Wales JKThe effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover studyDiabet Med.(1985 Mar)
  50. HbA1c - Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GDAscorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trialDiabetes Obes Metab.(2019 Mar)
  51. HbA1c - Dakhale GN, Chaudhari HV, Shrivastava MSupplementation of vitamin C reduces blood glucose and improves glycosylated hemoglobin in type 2 diabetes mellitus: a randomized, double-blind studyAdv Pharmacol Sci.(2011)
  52. HbA1c - Mahmoudabadi MM, Djalali M, Djazayery SA, Keshavarz SA, Eshraghian MR, Yaraghi AA, Askari G, Ghiasvand R, Zarei MEffects of eicosapentaenoic acid and vitamin C on glycemic indices, blood pressure, and serum lipids in type 2 diabetic Iranian malesJ Res Med Sci.(2011 Mar)
  53. HbA1c - Mason SA, Della Gatta PA, Snow RJ, Russell AP, Wadley GDAscorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled studyFree Radic Biol Med.(2016 Apr)
  54. HbA1c - Camargo JL, Stifft J, Gross JLThe effect of aspirin and vitamins C and E on HbA1c assaysClin Chim Acta.(2006 Oct)
  55. HbA1c - Klein F, Juhl B, Christiansen JSUnchanged renal haemodynamics following high dose ascorbic acid administration in normoalbuminuric IDDM patientsScand J Clin Lab Invest.(1995 Feb)
  56. HbA1c - JAYESH K BHATT, SABIN THOMAS, NANJAN MJEFFECT OF ORAL SUPPLEMENTATION OF VITAMIN C ON GLYCEMIC CONTROL AND LIPID PROFILE IN PATIENTS WITH TYPE 2 DIABETES MELLITUSInternational Journal of Pharmacy and Pharmaceutical Sciences.()
  57. Blood glucose - Chen H, Karne RJ, Hall G, Campia U, Panza JA, Cannon RO 3rd, Wang Y, Katz A, Levine M, Quon MJHigh-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistanceAm J Physiol Heart Circ Physiol.(2006 Jan)
  58. Blood glucose - Tousoulis D, Antoniades C, Vasiliadou C, Kourtellaris P, Koniari K, Marinou K, Charakida M, Ntarladimas I, Siasos G, Stefanadis CEffects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitusHeart.(2007 Feb)
  59. Blood glucose - Gutierrez AD, Duran-Valdez E, Robinson I, de Serna DG, Schade DSDoes short-term vitamin C reduce cardiovascular risk in type 2 diabetes?Endocr Pract.(2013 Sep-Oct)
  60. Blood glucose - Ellulu MS, Rahmat A, Patimah I, Khaza'ai H, Abed YEffect of vitamin C on inflammation and metabolic markers in hypertensive and/or diabetic obese adults: a randomized controlled trialDrug Des Devel Ther.(2015 Jul 1)
  61. Blood glucose - Ghaffari et alThe effects of vitamin C on diabetic patients Pharm Lett.()
  62. Glycemic Control - Mazloom Z, Hejazi N, Dabbaghmanesh MH, Tabatabaei HR, Ahmadi A, Ansar HEffect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patientsPak J Biol Sci.(2011 Oct 1)
  63. HbA1c - Parikh P, Mani U, Iyer URole of Spirulina in the Control of Glycemia and Lipidemia in Type 2 Diabetes MellitusJ Med Food.(2001 Winter)
  64. HbA1c - Lee EH, Park JE, Choi YJ, Huh KB, Kim WYA randomized study to establish the effects of spirulina in type 2 diabetes mellitus patientsNutr Res Pract.(2008 Winter)
  65. HbA1c - Hatami E, Ghalishourani SS, Najafgholizadeh A, Pourmasoumi M, Hadi A, Clark CCT, Assaroudi M, Salehi-Sahlabadi A, Joukar F, Mansour-Ghanaei FThe effect of spirulina on type 2 diabetes: a systematic review and meta-analysis.J Diabetes Metab Disord.(2021-Jun)
  66. Weight - Meysam Zarezadeh, Amir Hossein Faghfouri, Nima Radkhah, Elaheh Foroumandi, Masoud Khorshidi, Ahmadreza Rasouli, Mahtab Zarei, Niyaz Mohammadzadeh Honarvar, Nazanin Hazhir Karzar, Mehrangiz Ebrahimi MamaghaniSpirulina supplementation and anthropometric indices: A systematic review and meta-analysis of controlled clinical trialsPhytother Res.(2020 Sep 23)
  67. Interleukin 2 - Sara Mohiti, Meysam Zarezadeh, Fatemeh Naeini, Helda Tutunchi, Alireza Ostadrahimi, Zohreh Ghoreishi, Mehrangiz Ebrahimi MamaghaniSpirulina supplementation and oxidative stress and pro-inflammatory biomarkers: A systematic review and meta-analysis of controlled clinical trialsClin Exp Pharmacol Physiol.(2021 Aug)
  68. HbA1c - Ximing Liu, Ha-Jun Zhou, Peter RohdewaldFrench maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patientsDiabetes Care.(2004 Mar)
  69. HbA1c - Zibadi S, Rohdewald PJ, Park D, Watson RRReduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementationNutr Res.(2008 May)
  70. HbA1c - Armaghan Moravej Aleali, Reza Amani, Hajieh Shahbazian, Frough Namjooyan, Seyed Mahmoud Latifi, Bahman CheraghianThe effect of hydroalcoholic Saffron (Crocus sativus L.) extract on fasting plasma glucose, HbA1c, lipid profile, liver, and renal function tests in patients with type 2 diabetes mellitus: A randomized double-blind clinical trialPhytother Res.(2019 Jun)
  71. HbA1c - Paria Azimi, Reza Ghiasvand, Awat Feizi, Mitra Hariri, Behnoud AbbasiEffects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes PatientsRev Diabet Stud.(Fall-Winter 2014)
  72. HbA1c - Fatemeh Ebrahimi, Amirhossein Sahebkar, Naheed Aryaeian, Naseh Pahlavani, Soudabeh Fallah, Nariman Moradi, Davoud Abbasi, Agha Fatemeh HosseiniEffects Of Saffron Supplementation On Inflammation And Metabolic Responses In Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled TrialDiabetes Metab Syndr Obes.(2019 Oct 14)
  73. HbA1c - Milajerdi A, Jazayeri S, Hashemzadeh N, Shirzadi E, Derakhshan Z, Djazayeri A, Akhondzadeh SThe effect of saffron (Crocus sativus L.) hydroalcoholic extract on metabolic control in type 2 diabetes mellitus: A triple-blinded randomized clinical trialJ Res Med Sci.(2018 Feb 20)
  74. HbA1c - Hajieh Shahbazian, Armaghan Moravej Aleali, Reza Amani, Foroogh Namjooyan, Bahman Cheraghian, Seyed Mahmoud Latifi, Sara Bahrainian, Ataallah GhadiriEffects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trialAvicenna J Phytomed.(Sep-Oct 2019)
  75. HbA1c - Amatto PPG, Chaves L, Braga GG, Carmona F, Pereira AMSEffect of Crocus sativus L. (saffron) and crocin in the treatment of patients with type-2 diabetes mellitus: A systematic review and meta-analysis.J Ethnopharmacol.(2023-Sep-29)
  76. Total Antioxidant Capacity (TAC) - Abedi A, Ghobadi H, Sharghi A, Iranpour S, Fazlzadeh M, Aslani MREffect of saffron supplementation on oxidative stress markers (MDA, TAC, TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated systematic review and meta-analysis of randomized placebo-controlled trials.Front Med (Lausanne).(2023)
  77. C-Reactive Protein (CRP) - Asbaghi O, Sadeghian M, Sadeghi O, Rigi S, Tan SC, Shokri A, Mousavi SMEffects of saffron (Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta-analysis.Phytother Res.(2021-Jan)
  78. Uric Acid - Milajerdi A, et alThe effect of saffron (Crocus sativus L.) hydro-alcoholic extract on liver and renal functions in type 2 diabetic patients: A double-blinded randomized and placebo control trialJournal of Nutrition & Intermediary Metabolism.()
  79. Blood Pressure - Paria Azimi, Reza Ghiasvand, Awat Feizi, Javad Hosseinzadeh, Maryam Bahreynian, Mitra Hariri, Hossein Khosravi-BoroujeniEffect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trialBlood Press.(2016 Jun)
  80. Erections - Hossein Mohammadzadeh-Moghadam, Seyed Mohammad Nazari, Ali Shamsa, Mohammad Kamalinejad, Habibollah Esmaeeli, Amir Abbas Asadpour, Abdoljavad KhajaviEffects of a Topical Saffron (Crocus sativus L) Gel on Erectile Dysfunction in Diabetics: A Randomized, Parallel-Group, Double-Blind, Placebo-Controlled TrialJ Evid Based Complementary Altern Med.(2015 Oct)
  81. Anxiety Symptoms - Shahdadi H, Balouchi A, Dehghanmehr S Effect of saffron oral capsule on anxiety and quality of sleep of diabetic patients in a tertiary healthcare facility in southeastern Iran: A quasi-experimental studyTrop J Pharm Res.()
  82. HbA1c - Lai MHAntioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitusJ Clin Biochem Nutr.(2008 Nov)
  83. HbA1c - Kleefstra N, Houweling ST, Bakker SJ, Verhoeven S, Gans RO, Meyboom-de Jong B, Bilo HJChromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trialDiabetes Care.(2007 May)
  84. HbA1c - Pei D, Hsieh CH, Hung YJ, Li JC, Lee CH, Kuo SWThe influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trialMetabolism.(2006 Jul)
  85. HbA1c - Anderson RA, Roussel AM, Zouari N, Mahjoub S, Matheau JM, Kerkeni APotential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitusJ Am Coll Nutr.(2001 Jun)
  86. HbA1c - Omid Asbaghi, Naeini Fatemeh, Rezaei Kelishadi Mahnaz, Ghaedi Ehsan, Eslampour Elham, Nazarian Behzad, Ashtary-Larky Damoon, Alavi Naeini AmirmansourEffects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trialsPharmacol Res.(2020 Jul 28)
  87. HbA1c - Paiva AN, Lima JG, Medeiros AC, Figueiredo HA, Andrade RL, Ururahy MA, Rezende AA, Brandão-Neto J, Almeida MdBeneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical studyJ Trace Elem Med Biol.(2015 Oct)
  88. HbA1c - Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng JElevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetesDiabetes.(1997 Nov)
  89. HbA1c - Vrtovec M, Vrtovec B, Briski A, Kocijancic A, Anderson RA, Radovancevic BChromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitusAm Heart J.(2005 Apr)
  90. HbA1c - Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, Chowdhury SRole of chromium supplementation in Indians with type 2 diabetes mellitusJ Nutr Biochem.(2002 Nov)
  91. HbA1c - Fengyi Zhao, Da Pan, Niannian Wang, Hui Xia, Hong Zhang, Shaokang Wang, Guiju SunEffect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysisBiol Trace Elem Res.(2022 Feb)
  92. HbA1c - Cefalu WT, Rood J, Pinsonat P, Qin J, Sereda O, Levitan L, Anderson RA, Zhang XH, Martin JM, Martin CK, Wang ZQ, Newcomer BCharacterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitusMetabolism.(2010 May)
  93. HbA1c - Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal VBeneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetesJ Trace Elem Med Biol.(2011 Jul)
  94. HbA1c - Kleefstra N, Houweling ST, Jansman FG, Groenier KH, Gans RO, Meyboom-de Jong B, Bakker SJ, Bilo HJChromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trialDiabetes Care.(2006 Mar)
  95. HbA1c - Racek J, Trefil L, Rajdl D, Mudrová V, Hunter D, Senft VInfluence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitusBiol Trace Elem Res.(2006 Mar)
  96. HbA1c - Król E, Krejpcio Z, Byks H, Bogdański P, Pupek-Musialik DEffects of chromium brewer's yeast supplementation on body mass, blood carbohydrates, and lipids and minerals in type 2 diabetic patientsBiol Trace Elem Res.(2011 Nov)
  97. Blood glucose - Gunton JE, Cheung NW, Hitchman R, Hams G, O'Sullivan C, Foster-Powell K, McElduff AChromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired glucose toleranceDiabetes Care.(2005 Mar)
  98. Blood glucose - Bahijiri SM, Mira SA, Mufti AM, Ajabnoor MAThe effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetesSaudi Med J.(2000 Sep)
  99. Blood glucose - Julie Martin, Zhong Q Wang, Xian H Zhang, Deborah Wachtel, Julia Volaufova, Dwight E Matthews, William T CefaluChromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetesDiabetes Care.(2006 Aug)
  100. Apolipoprotein A - Shahinfar H, Amini MR, Sheikhhossein F, Djafari F, Jafari A, Shab-Bidar SThe effect of chromium supplementation on apolipoproteins: A systematic review and meta-analysis of randomized clinical trials.Clin Nutr ESPEN.(2020-Dec)
  101. Total Antioxidant Capacity (TAC) - Morvaridzadeh M, Estêvão MD, Qorbani M, Heydari H, Hosseini AS, Fazelian S, Belančić A, Persad E, Rezamand G, Heshmati JThe effect of chromium intake on oxidative stress parameters: A systematic review and meta-analysis.J Trace Elem Med Biol.(2022-Jan)
  102. C-Reactive Protein (CRP) - Zhang X, Cui L, Chen B, Xiong Q, Zhan Y, Ye J, Yin QEffect of chromium supplementation on hs-CRP, TNF-α and IL-6 as risk factor for cardiovascular diseases: A meta-analysis of randomized-controlled trials.Complement Ther Clin Pract.(2021-Feb)
  103. Blood Pressure - Ghanbari M, Amini MR, Djafarian K, Shab-Bidar SThe effects of chromium supplementation on blood pressure: a systematic review and meta-analysis of randomized clinical trials.Eur J Clin Nutr.(2022-Mar)
  104. Oxidative Stress Biomarkers - Cheng HH, Lai MH, Hou WC, Huang CLAntioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjectsJ Agric Food Chem.(2004 Mar 10)
  105. HbA1c - Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning GTreatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberineJ Clin Endocrinol Metab.(2008 Jul)
  106. HbA1c - Dong H, Wang N, Zhao L, Lu FBerberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysisEvid Based Complement Alternat Med.(2012)
  107. HbA1c - Zamani M, Zarei M, Nikbaf-Shandiz M, Hosseini S, Shiraseb F, Asbaghi OThe effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis.Front Nutr.(2022)
  108. HbA1c - Xie W, Su F, Wang G, Peng Z, Xu Y, Zhang Y, Xu N, Hou K, Hu Z, Chen Y, Chen RGlucose-lowering effect of berberine on type 2 diabetes: A systematic review and meta-analysis.Front Pharmacol.(2022)
  109. High-density lipoprotein (HDL) - Blais JE, Huang X, Zhao JVOverall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.Drugs.(2023-Apr)
  110. HbA1c - Boden G, Sargrad K, Homko C, Mozzoli M, Stein TPEffect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetesAnn Intern Med.(2005 Mar 15)
  111. HbA1c - Athinarayanan SJ, Adams RN, Hallberg SJ, McKenzie AL, Bhanpuri NH, Campbell WW, Volek JS, Phinney SD, McCarter JPLong-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical TrialFront Endocrinol (Lausanne).(2019 Jun 5)
  112. HbA1c - Mohamed Rafiullah, Mohthash Musambil, Satish Kumar DavidEffect of a very low-carbohydrate ketogenic diet vs recommended diets in patients with type 2 diabetes: a meta-analysisNutr Rev.(2021 Aug 2)
  113. HbA1c - Yeo Jin Choi, Sang-Min Jeon, Sooyoung ShinImpact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled TrialsNutrients.(2020 Jul 6)
  114. HbA1c - Jing T, Zhang S, Bai M, Chen Z, Gao S, Li S, Zhang JEffect of Dietary Approaches on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review with Network Meta-Analysis of Randomized Trials.Nutrients.(2023-Jul-15)
  115. HbA1c - Parry-Strong A, Wright-McNaughton M, Weatherall M, Hall RM, Coppell KJ, Barthow C, Krebs JDVery low carbohydrate (ketogenic) diets in type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.Diabetes Obes Metab.(2022-Dec)
  116. HbA1c - Choy KYC, Louie JCYThe effects of the ketogenic diet for the management of type 2 diabetes mellitus: A systematic review and meta-analysis of recent studies.Diabetes Metab Syndr.(2023-Dec)
  117. HbA1c - Zhou C, Wang M, Liang J, He G, Chen NKetogenic Diet Benefits to Weight Loss, Glycemic Control, and Lipid Profiles in Overweight Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trails.Int J Environ Res Public Health.(2022 Aug 22)
  118. Blood glucose - Myette-Côté É, Durrer C, Neudorf H, Bammert TD, Botezelli JD, Johnson JD, DeSouza CA, Little JPThe effect of a short-term low-carbohydrate, high-fat diet with or without postmeal walks on glycemic control and inflammation in type 2 diabetes: a randomized trialAm J Physiol Regul Integr Comp Physiol.(2018 Dec 1)
  119. Weight - Mohammad Reza Amini, Azadeh Aminianfar, Sina Naghshi, Bagher Larijani, Ahmad EsmaillzadehThe effect of ketogenic diet on body composition and anthropometric measures: A systematic review and meta-analysis of randomized controlled trialsCrit Rev Food Sci Nutr.(2021 Jan 14)
  120. C-Reactive Protein (CRP) - Francois ME, Myette-Cote E, Bammert TD, Durrer C, Neudorf H, DeSouza CA, Little JPCarbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves endothelial function in type 2 diabetesAm J Physiol Heart Circ Physiol.(2018 Jan 1)
  121. Uric Acid - Gohari S, Ghobadi S, Jafari A, Ahangar H, Gohari S, Mahjani MThe effect of dietary approaches to stop hypertension and ketogenic diets intervention on serum uric acid concentration: a systematic review and meta-analysis of randomized controlled trials.Sci Rep.(2023 Jun 28)
  122. HbA1c - Nicola Veronese, Ligia J Dominguez, Damiano Pizzol, Jacopo Demurtas, Lee Smith, Mario BarbagalloOral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled TrialsNutrients.(2021 Nov 15)
  123. HbA1c - Guerrero-Romero F, Rodríguez-Morán MThe effect of lowering blood pressure by magnesium supplementation in diabetic hypertensive adults with low serum magnesium levels: a randomized, double-blind, placebo-controlled clinical trialJ Hum Hypertens.(2009 Apr)
  124. HbA1c - Verma H, Garg REffect of magnesium supplementation on type 2 diabetes associated cardiovascular risk factors: a systematic review and meta-analysisJ Hum Nutr Diet.(2017 Oct)
  125. HbA1c - de Lordes Lima M, Cruz T, Pousada JC, Rodrigues LE, Barbosa K, Canguçu VThe effect of magnesium supplementation in increasing doses on the control of type 2 diabetesDiabetes Care.(1998 May)
  126. HbA1c - de Valk HW, Verkaaik R, van Rijn HJ, Geerdink RA, Struyvenberg AOral magnesium supplementation in insulin-requiring Type 2 diabetic patientsDiabet Med.(1998 Jun)
  127. HbA1c - Rodríguez-Morán M, Guerrero-Romero FOral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trialDiabetes Care.(2003 Apr)
  128. HbA1c - Xu L, Li X, Wang X, Xu MEffects of magnesium supplementation on improving hyperglycemia, hypercholesterolemia, and hypertension in type 2 diabetes: A pooled analysis of 24 randomized controlled trials.Front Nutr.(2022)
  129. HbA1c - Chua FB, Cinco JE, Paz-Pacheco EEfficacy of Magnesium Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Meta-analysis.J ASEAN Fed Endocr Soc.(2017)
  130. HbA1c - Asbaghi O, Moradi S, Kashkooli S, Zobeiri M, Nezamoleslami S, Hojjati Kermani MA, Lazaridi AV, Miraghajani MThe effects of oral magnesium supplementation on glycaemic control in patients with type 2 diabetes: a systematic review and dose-response meta-analysis of controlled clinical trials.Br J Nutr.(2022-Dec-28)
  131. Weight - Asbaghi O, Hosseini R, Boozari B, Ghaedi E, Kashkooli S, Moradi SThe Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: a Systematic Review and Meta-analysis of Randomized Controlled Trials.Biol Trace Elem Res.(2021-Feb)
  132. High-density lipoprotein (HDL) - Asbaghi O, Moradi S, Nezamoleslami S, Moosavian SP, Hojjati Kermani MA, Lazaridi AV, Miraghajani MThe Effects of Magnesium Supplementation on Lipid Profile Among Type 2 Diabetes Patients: a Systematic Review and Meta-analysis of Randomized Controlled Trials.Biol Trace Elem Res.(2021-Mar)
  133. Magnesium Excretion - Zamani M, Haghighat NThe Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clin Nutr Res.(2022-Apr)
  134. HbA1c - Shidfar F, Keshavarz A, Hosseyni S, Ameri A, Yarahmadi SEffects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patientsEast Mediterr Health J.(2008 Mar-Apr)
  135. HbA1c - Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulangé A, Vidal H, Slama G, Clément K, Guerre-Millo M, Rizkalla SWTreatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled studyAm J Clin Nutr.(2007 Dec)
  136. HbA1c - Morgan WA, Raskin P, Rosenstock JA comparison of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDMDiabetes Care.(1995 Jan)
  137. HbA1c - Boberg M, Pollare T, Siegbahn A, Vessby BSupplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetes mellitusEur J Clin Invest.(1992 Oct)
  138. HbA1c - McManus RM, Jumpson J, Finegood DT, Clandinin MT, Ryan EAA comparison of the effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type II diabetesDiabetes Care.(1996 May)
  139. HbA1c - M Gorety Jacobo-Cejudo, Roxana Valdés-Ramos, Ana L Guadarrama-López, Rosa-Virgen Pardo-Morales, Beatriz E Martínez-Carrillo, Laurence S HarbigeEffect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus PatientsNutrients.(2017 Jun 3)
  140. HbA1c - Pooya Sh, Jalali MD, Jazayery AD, Saedisomeolia A, Eshraghian MR, Toorang FThe efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patientsNutr Metab Cardiovasc Dis.(2010 Jun)
  141. HbA1c - Schectman G, Kaul S, Kissebah AHEffect of fish oil concentrate on lipoprotein composition in NIDDMDiabetes.(1988 Nov)
  142. HbA1c - Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJEffects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertensionAm J Clin Nutr.(2002 Nov)
  143. Blood glucose - Goh YK, Jumpsen JA, Ryan EA, Clandinin MTEffect of omega 3 fatty acid on plasma lipids, cholesterol and lipoprotein fatty acid content in NIDDM patientsDiabetologia.(1997 Jan)
  144. Blood glucose - Hendra TJ, Britton ME, Roper DR, Wagaine-Twabwe D, Jeremy JY, Dandona P, Haines AP, Yudkin JSEffects of fish oil supplements in NIDDM subjects. Controlled studyDiabetes Care.(1990 Aug)
  145. Blood glucose - Connor WE, Prince MJ, Ullmann D, Riddle M, Hatcher L, Smith FE, Wilson DThe hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose controlAnn N Y Acad Sci.(1993 Jun 14)
  146. Blood glucose - Pelikánová T, Kohout M, Válek J, Kazdová L, Base JMetabolic effects of omega-3 fatty acids in type 2 (non-insulin-dependent) diabetic patientsAnn N Y Acad Sci.(1993 Jun 14)
  147. Blood glucose - Borkman M, Chisholm DJ, Furler SM, Storlien LH, Kraegen EW, Simons LA, Chesterman CNEffects of fish oil supplementation on glucose and lipid metabolism in NIDDMDiabetes.(1989 Oct)
  148. Insulin - Annuzzi G, Rivellese A, Capaldo B, Di Marino L, Iovine C, Marotta G, Riccardi GA controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patientsAtherosclerosis.(1991 Mar)
  149. Glycemic Control - Akinkuolie AO, Ngwa JS, Meigs JB, Djoussé LOmega-3 polyunsaturated fatty acid and insulin sensitivity: a meta-analysis of randomized controlled trialsClin Nutr.(2011 Dec)
  150. Triglycerides - Montori VM, Farmer A, Wollan PC, Dinneen SFFish oil supplementation in type 2 diabetes: a quantitative systematic reviewDiabetes Care.(2000 Sep)
  151. Triglycerides - Rizza S, Tesauro M, Cardillo C, Galli A, Iantorno M, Gigli F, Sbraccia P, Federici M, Quon MJ, Lauro DFish oil supplementation improves endothelial function in normoglycemic offspring of patients with type 2 diabetesAtherosclerosis.(2009 Oct)
  152. HbA1c - Neal D Barnard, Joshua Cohen, David J A Jenkins, Gabrielle Turner-McGrievy, Lise Gloede, Brent Jaster, Kim Seidl, Amber A Green, Stanley TalpersA low-fat vegan diet improves glycemic control and cardiovascular risk factors in a randomized clinical trial in individuals with type 2 diabetesDiabetes Care.(2006 Aug)
  153. HbA1c - Yu-Mi Lee, Se-A Kim, In-Kyu Lee, Jung-Guk Kim, Keun-Gyu Park, Ji-Yun Jeong, Jae-Han Jeon, Ji-Yeon Shin, Duk-Hee LeeEffect of a Brown Rice Based Vegan Diet and Conventional Diabetic Diet on Glycemic Control of Patients with Type 2 Diabetes: A 12-Week Randomized Clinical TrialPLoS One.(2016 Jun 2)
  154. HbA1c - Neal D Barnard, Joshua Cohen, David J A Jenkins, Gabrielle Turner-McGrievy, Lise Gloede, Amber Green, Hope FerdowsianA low-fat vegan diet and a conventional diabetes diet in the treatment of type 2 diabetes: a randomized, controlled, 74-wk clinical trialAm J Clin Nutr.(2009 May)
  155. HbA1c - Yoko Yokoyama, Neal D Barnard, Susan M Levin, Mitsuhiro WatanabeVegetarian diets and glycemic control in diabetes: a systematic review and meta-analysisCardiovasc Diagn Ther.(2014 Oct)
  156. Weight - Neal D Barnard, Susan M Levin, Lise Gloede, Rosendo FloresTurning the Waiting Room into a Classroom: Weekly Classes Using a Vegan or a Portion-Controlled Eating Plan Improve Diabetes Control in a Randomized Translational StudyJ Acad Nutr Diet.(2018 Jun)
  157. Blood Pressure - S Mishra, J Xu, U Agarwal, J Gonzales, S Levin, N D BarnardA multicenter randomized controlled trial of a plant-based nutrition program to reduce body weight and cardiovascular risk in the corporate setting: the GEICO studyEur J Clin Nutr.(2013 Jul)
  158. Blood Pressure - Amir Abbasnezhad, Ebrahim Falahi, Michael J Gonzalez, Parivash Kavehi, Faezeh Fouladvand, Razieh ChoghakhoriEffect of Different Dietary Approaches Compared With a Regular Diet on Systolic and Diastolic Blood Pressure in Patients With Type 2 Diabetes: A Systematic Review and Meta-AnalysisDiabetes Res Clin Pract.(2020 May)
  159. Blood Pressure - Edelweiss Ramal, Andrea Champlin, Khaled BahjriImpact of a Plant-Based Diet and Support on Mitigating Type 2 Diabetes Mellitus in Latinos Living in Medically Underserved AreasAm J Health Promot.(2018 Mar)
  160. Depression Symptoms - Ulka Agarwal, Suruchi Mishra, Jia Xu, Susan Levin, Joseph Gonzales, Neal D BarnardA multicenter randomized controlled trial of a nutrition intervention program in a multiethnic adult population in the corporate setting reduces depression and anxiety and improves quality of life: the GEICO studyAm J Health Promot.(Mar-Apr 2015)
  161. HbA1c - Gholami M, Zarei P, Sadeghi Sedeh B, Rafiei F, Khosrowbeygi AEffects of coenzyme Q10 supplementation on serum values of adiponectin, leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetesGynecol Endocrinol.(2018 Dec)
  162. HbA1c - Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke VCoenzyme Q(10) improves endothelial dysfunction of the brachial artery in Type II diabetes mellitusDiabetologia.(2002 Mar)
  163. HbA1c - Hodgson JM, Watts GF, Playford DA, Burke V, Croft KDCoenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetesEur J Clin Nutr.(2002 Nov)
  164. HbA1c - Fallah M, Askari G, Soleimani A, Feizi A, Asemi ZClinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patientsInt Urol Nephrol.(2018 Nov)
  165. HbA1c - Shi-Ying Zhang, Kai-Lin Yang, Liu-Ting Zeng, Xiao-He Wu, Hui-Yong HuangEffectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-AnalysisInt J Endocrinol.(2018 Sep 16)
  166. HbA1c - Dludla PV, Nyambuya TM, Orlando P, Silvestri S, Mxinwa V, Mokgalaboni K, Nkambule BB, Louw J, Muller CJF, Tiano LThe impact of coenzyme Q on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials.Endocrinol Diabetes Metab.(2020-Apr)
  167. Interleukin 6 - Mirhashemi SM, Najafi V, Raygan F, Asemi ZThe effects of coenzyme Q10 supplementation on cardiometabolic markers in overweight type 2 diabetic patients with stable myocardial infarction: A randomized, double-blind, placebo-controlled trialARYA Atheroscler.(2016 Jul)
  168. Endothelial Function - Hamilton SJ, Chew GT, Watts GFCoenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patientsDiabetes Care.(2009 May)
  169. HbA1c - Bajorek SA, Morello CMEffects of dietary fiber and low glycemic index diet on glucose control in subjects with type 2 diabetes mellitusAnn Pharmacother.(2010 Nov)
  170. HbA1c - Sierra M, García JJ, Fernández N, Diez MJ, Calle APTherapeutic effects of psyllium in type 2 diabetic patientsEur J Clin Nutr.(2002 Sep)
  171. Blood glucose - Rodríguez-Morán M, Guerrero-Romero F, Lazcano-Burciaga GLipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetesJ Diabetes Complications.(1998 Sep-Oct)
  172. High-density lipoprotein (HDL) - Sartore G, Reitano R, Barison A, Magnanini P, Cosma C, Burlina S, Manzato E, Fedele D, Lapolla AThe effects of psyllium on lipoproteins in type II diabetic patientsEur J Clin Nutr.(2009 Oct)
  173. HbA1c - Balzer J, Rassaf T, Heiss C, Kleinbongard P, Lauer T, Merx M, Heussen N, Gross HB, Keen CL, Schroeter H, Kelm MSustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trialJ Am Coll Cardiol.(2008 Jun 3)
  174. Blood Flow - Andrew B. Petrone, J. Michael Gaziano, Luc DjousséEffects of Dark Chocolate and Cocoa Products on Endothelial Function: A Meta-AnalysisCurrent Nutrition Reports.()
  175. Mitochondrial Protection - Pam R Taub, Israel Ramirez-Sanchez, Theodore P Ciaraldi, Guy Perkins, Anne N Murphy, Robert Naviaux, Michael Hogan, Alan S Maisel, Robert R Henry, Guillermo Ceballos, Francisco VillarrealAlterations in skeletal muscle indicators of mitochondrial structure and biogenesis in patients with type 2 diabetes and heart failure: effects of epicatechin rich cocoaClin Transl Sci.(2012 Feb)
  176. HbA1c - Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SHEfficacy of Tribulus Terrestris Extract on the Serum Glucose and Lipids of Women with Diabetes MellitusIran J Med Sci.(2016 May)
  177. HbA1c - Felipe Mendes Delpino, Lílian Munhoz FigueiredoResveratrol supplementation and type 2 diabetes: a systematic review and meta-analysisCrit Rev Food Sci Nutr.(2021 Jan 22)
  178. HbA1c - García-Martínez BI, Ruiz-Ramos M, Pedraza-Chaverri J, Santiago-Osorio E, Mendoza-Núñez VMInfluence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.Molecules.(2022-Aug-16)
  179. HbA1c - Liu K, Zhou R, Wang B, Mi MTEffect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.Am J Clin Nutr.(2014-Jun)
  180. HbA1c - Zhu X, Wu C, Qiu S, Yuan X, Li LEffects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis.Nutr Metab (Lond).(2017)
  181. HbA1c - Hausenblas HA, Schoulda JA, Smoliga JMResveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis.Mol Nutr Food Res.(2015-Jan)
  182. HbA1c - Guo XF, Li JM, Tang J, Li DEffects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials.Crit Rev Food Sci Nutr.(2018)
  183. Insulin - Sheida Zeraattalab-Motlagh, Ahmad Jayedi, Sakineh Shab-BidarThe effects of resveratrol supplementation in patients with type 2 diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an umbrella review of meta-analyses of randomized controlled trialsAm J Clin Nutr.(2021 Nov 8)
  184. Insulin - Consolato Sergi, Bonnie Chiu, Joseph Feulefack, Fan Shen, Brian ChiuUsefulness of resveratrol supplementation in decreasing cardiometabolic risk factors comparing subjects with metabolic syndrome and healthy subjects with or without obesity: meta-analysis using multinational, randomised, controlled trialsArch Med Sci Atheroscler Dis.(2020 May 30)
  185. Insulin - Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AYThe effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis.Med Clin (Barc).(2022-Jun-24)
  186. Glycemic Control - Brasnyó P, Molnár GA, Mohás M, Markó L, Laczy B, Cseh J, Mikolás E, Szijártó IA, Mérei A, Halmai R, Mészáros LG, Sümegi B, Wittmann IResveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patientsBr J Nutr.(2011 Aug)
  187. Glycemic Control - Crandall JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai NPilot Study of Resveratrol in Older Adults With Impaired Glucose ToleranceJ Gerontol A Biol Sci Med Sci.(2012 Jan 4)
  188. Weight - Mousavi SM, Milajerdi A, Sheikhi A, Kord-Varkaneh H, Feinle-Bisset C, Larijani B, Esmaillzadeh AResveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials.Obes Rev.(2019-Mar)
  189. Total Antioxidant Capacity (TAC) - Omidian M, Abdolahi M, Daneshzad E, Sedighiyan M, Aghasi M, Abdollahi H, Omidian P, Dabiri S, Mahmoudi MThe Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Endocr Metab Immune Disord Drug Targets.(2020)
  190. Total Antioxidant Capacity (TAC) - Koushki M, Lakzaei M, Khodabandehloo H, Hosseini H, Meshkani R, Panahi GTherapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials.Postgrad Med J.(2020-Apr)
  191. High-density lipoprotein (HDL) - Maryam Akbari, Omid Reza Tamtaji, Kamran B Lankarani, Reza Tabrizi, Ehsan Dadgostar, Neda Haghighat, Fariba Kolahdooz, Amir Ghaderi, Mohammad Ali Mansournia, Zatollah AsemiThe effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trialsLipids Health Dis.(2020 Feb 17)
  192. High-density lipoprotein (HDL) - Zhao H, Song A, Zhang Y, Shu L, Song G, Ma HEffect of Resveratrol on Blood Lipid Levels in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Obesity (Silver Spring).(2019-Jan)
  193. High-density lipoprotein (HDL) - Sahebkar AEffects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials.Nutr Rev.(2013-Dec)
  194. High-density lipoprotein (HDL) - Gu W, Geng J, Zhao H, Li X, Song GEffects of Resveratrol on Metabolic Indicators in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis.Int J Clin Pract.(2022)
  195. High-density lipoprotein (HDL) - Cao X, Liao W, Xia H, Wang S, Sun GThe Effect of Resveratrol on Blood Lipid Profile: A Dose-Response Meta-Analysis of Randomized Controlled Trials.Nutrients.(2022-Sep-11)
  196. Total cholesterol - Sahar Rafiee, Hamed Mohammadi, Abed Ghavami, Erfan Sadeghi, Zahra Safari, Gholamreza AskariEfficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trialsComplement Ther Clin Pract.(2020 Dec 4)
  197. C-Reactive Protein (CRP) - Haghighatdoost F, Hariri MCan resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials.Eur J Clin Nutr.(2019-Mar)
  198. C-Reactive Protein (CRP) - Tabrizi R, Tamtaji OR, Lankarani KB, Mirhosseini N, Akbari M, Dadgostar E, Peymani P, Asemi ZThe effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials.Food Funct.(2018-Dec-13)
  199. C-Reactive Protein (CRP) - Custodero C, Mankowski RT, Lee SA, Chen Z, Wu S, Manini TM, Hincapie Echeverri J, Sabbà C, Beavers DP, Cauley JA, Espeland MA, Fielding RA, Kritchevsky SB, Liu CK, McDermott MM, Miller ME, Tracy RP, Newman AB, Ambrosius WT, Pahor M, Anton SDEvidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta-analysis.Ageing Res Rev.(2018-Sep)
  200. C-Reactive Protein (CRP) - Koushki M, Dashatan NA, Meshkani REffect of Resveratrol Supplementation on Inflammatory Markers: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Clin Ther.(2018-Jul)
  201. Fasting Glucose - Raimundo AF, Félix F, Andrade R, García-Conesa MT, González-Sarrías A, Gilsa-Lopes J, do Ó D, Raimundo A, Ribeiro R, Rodriguez-Mateos A, Santos CN, Schär M, Silva A, Cruz I, Wang B, Pinto P, Menezes RCombined effect of interventions with pure or enriched mixtures of (poly)phenols and anti-diabetic medication in type 2 diabetes management: a meta-analysis of randomized controlled human trials.Eur J Nutr.(2020-Jun)
  202. Uric Acid - Abdollahi S, Vajdi M, Meshkini F, Vasmehjani AA, Sangsefidi ZS, Clark CCT, Soltani SResveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials.Nutr Res.(2023-May)
  203. Blood Pressure - Samuel R Weaver, Catarina Rendeiro, Helen M McGettrick, Andrew Philp, Samuel J E LucasFine wine or sour grapes? A systematic review and meta-analysis of the impact of red wine polyphenols on vascular healthEur J Nutr.(2021 Feb)
  204. Blood Pressure - Lipert A, Szadkowska I, Matusiak-Wieczorek E, Kochan EThe Effect of Herbal Supplements on Blood Pressure: Systematic Review and Meta-Analysis.Antioxidants (Basel).(2022-Jul-22)
  205. Blood Pressure - Liu Y, Ma W, Zhang P, He S, Huang DEffect of resveratrol on blood pressure: a meta-analysis of randomized controlled trials.Clin Nutr.(2015-Feb)
  206. Interleukin 6 - Melodi Omraninava, Bahman Razi, Saeed Aslani, Danyal Imani, Tannaz Jamialahmadi, Amirhossein SahebkarEffect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trialsEur J Pharmacol.(2021 Oct 5)
  207. Endothelial Function - Mohammadipoor N, Shafiee F, Rostami A, Kahrizi MS, Soleimanpour H, Ghodsi M, Ansari MJ, Bokov DO, Jannat B, Mosharkesh E, Pour Abbasi MSResveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.Phytother Res.(2022-Sep)
  208. Adiponectin - Mohammadi-Sartang M, Mazloom Z, Sohrabi Z, Sherafatmanesh S, Barati-Boldaji RResveratrol supplementation and plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials.Pharmacol Res.(2017-Mar)
  209. Processing Speed - Marx W, Kelly JT, Marshall S, Cutajar J, Annois B, Pipingas A, Tierney A, Itsiopoulos CEffect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials.Nutr Rev.(2018-Jun-01)
  210. HbA1c - Mitri J, Dawson-Hughes B, Hu FB, Pittas AGEffects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trialAm J Clin Nutr.(2011 Aug)
  211. Insulin - Harris SS, Pittas AG, Palermo NJA randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African AmericansDiabetes Obes Metab.(2012 Sep)
  212. Insulin - A M Borissova, T Tankova, G Kirilov, L Dakovska, R KovachevaThe effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patientsInt J Clin Pract.(2003 May)
  213. Risk Of Cardiovascular Disease - Parker J, Hashmi O, Dutton D, Mavrodaris A, Stranges S, Kandala NB, Clarke A, Franco OHLevels of vitamin D and cardiometabolic disorders: systematic review and meta-analysisMaturitas.(2010 Mar)
  214. HbA1c - Olubukola Ajala, Patrick English, Jonathan PinkneySystematic review and meta-analysis of different dietary approaches to the management of type 2 diabetesAm J Clin Nutr.(2013 Mar)
  215. HbA1c - Bei Pan, Yiting Wu, Qingxia Yang, Long Ge, Caiyun Gao, Yangqin Xun, Jinhui Tian, Guowu DingThe impact of major dietary patterns on glycemic control, cardiovascular risk factors, and weight loss in patients with type 2 diabetes: A network meta-analysisJ Evid Based Med.(2019 Feb)
  216. HbA1c - Carter P, Achana F, Troughton J, Gray LJ, Khunti K, Davies MJA Mediterranean diet improves HbA1c but not fasting blood glucose compared to alternative dietary strategies: a network meta-analysis.J Hum Nutr Diet.(2014-Jun)
  217. Weight - Esposito K, Kastorini CM, Panagiotakos DB, Giugliano DMediterranean diet and weight loss: meta-analysis of randomized controlled trials.Metab Syndr Relat Disord.(2011-Feb)
  218. High-density lipoprotein (HDL) - Kastorini, C.M., et al.The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individualsJ Am Coll Cardiol.(2011-03-15)
  219. High-density lipoprotein (HDL) - Garcia M, Bihuniak JD, Shook J, Kenny A, Kerstetter J, Huedo-Medina TBThe Effect of the Traditional Mediterranean-Style Diet on Metabolic Risk Factors: A Meta-Analysis.Nutrients.(2016-Mar-15)
  220. High-density lipoprotein (HDL) - Neuenschwander M, Hoffmann G, Schwingshackl L, Schlesinger SImpact of different dietary approaches on blood lipid control in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis.Eur J Epidemiol.(2019-Sep)
  221. C-Reactive Protein (CRP) - Sánchez-Rosales AI, Guadarrama-López AL, Gaona-Valle LS, Martínez-Carrillo BE, Valdés-Ramos RThe Effect of Dietary Patterns on Inflammatory Biomarkers in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients.(2022-Oct-31)
  222. Endothelial Function - Shannon OM, Mendes I, Köchl C, Mazidi M, Ashor AW, Rubele S, Minihane AM, Mathers JC, Siervo MMediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.J Nutr.(2020-May-01)
  223. HbA1c - Miñambres I, Cuixart G, Gonçalves A, Corcoy REffects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trialsClin Nutr.(2019 Jun)
  224. HbA1c - Klein GA, Stefanuto A, Boaventura BC, de Morais EC, Cavalcante Lda S, de Andrade F, Wazlawik E, Di Pietro PF, Maraschin M, da Silva ELMate tea (Ilex paraguariensis) improves glycemic and lipid profiles of type 2 diabetes and pre-diabetes individuals: a pilot studyJ Am Coll Nutr.(2011 Oct)
  225. HbA1c - Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DMEffects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitusFolia Med (Plovdiv).(2002)
  226. HbA1c - Howes JB, Tran D, Brillante D, Howes LGEffects of dietary supplementation with isoflavones from red clover on ambulatory blood pressure and endothelial function in postmenopausal type 2 diabetesDiabetes Obes Metab.(2003 Sep)
  227. HbA1c - Monti LD, Setola E, Lucotti PC, Marrocco-Trischitta MM, Comola M, Galluccio E, Poggi A, Mammì S, Catapano AL, Comi G, Chiesa R, Bosi E, Piatti PMEffect of a long-term oral l-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trialDiabetes Obes Metab.(2012 Oct)
  228. Endothelin-1 - Lucotti P, Setola E, Monti LD, Galluccio E, Costa S, Sandoli EP, Fermo I, Rabaiotti G, Gatti R, Piatti PBeneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patientsAm J Physiol Endocrinol Metab.(2006 Nov)
  229. HbA1c - Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CGAntidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patientsHorm Metab Res.(2010 May)
  230. HbA1c - Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CGAntidiabetic Effects of Add-On Gynostemma pentaphyllum Extract Therapy with Sulfonylureas in Type 2 Diabetic PatientsEvid Based Complement Alternat Med.(2012)
  231. HbA1c - Joseph J Matthews, Eimear Dolan, Paul A Swinton, Lívia Santos, Guilherme G Artioli, Mark D Turner, Kirsty J Elliott-Sale, Craig SaleEffect of Carnosine or β-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysisAdv Nutr.(2021 Jul 31)
  232. HbA1c - Abdullah O Bamosa, Huda Kaatabi, Fatma M Lebdaa, Abdul-Muhssen Al Elq, Ali Al-SultanbEffect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitusIndian J Physiol Pharmacol.(Oct-Dec 2010)
  233. HbA1c - Saadati S, Naseri K, Asbaghi O, Abhari K, Zhang P, Li HB, Gan RY supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Front Nutr.(2022)
  234. Total Antioxidant Capacity (TAC) - Kavyani Z, Musazadeh V, Golpour-Hamedani S, Moridpour AH, Vajdi M, Askari GThe effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials.Inflammopharmacology.(2023-Jun)
  235. HbA1c - Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani BThe clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trialPhytother Res.(2009 Aug)
  236. HbA1c - Sotaniemi EA, Haapakoski E, Rautio AGinseng therapy in non-insulin-dependent diabetic patientsDiabetes Care.(1995 Oct)
  237. HbA1c - Effects of Panax ginseng on hyperglycemia, hypertension, and hyperlipidemia: A systematic review and meta-analysis.()
  238. HbA1c - Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials.()
  239. Blood glucose - Reeds DN, Patterson BW, Okunade A, Holloszy JO, Polonsky KS, Klein SGinseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetesDiabetes Care.(2011 May)
  240. HbA1c - Jayawardena MH, de Alwis NM, Hettigoda V, Fernando DJA double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetesJ Ethnopharmacol.(2005 Feb 28)
  241. Blood glucose - Williams JA, Choe YS, Noss MJ, Baumgartner CJ, Mustad VAExtract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetesAm J Clin Nutr.(2007 Jul)
  242. HbA1c - Małgorzata Jamka, Bartosz Kulczyński, Agata Juruć, Anna Gramza-Michałowska, Caroline S Stokes, Jarosław WalkowiakThe Effect of the Paleolithic Diet vs. Healthy Diets on Glucose and Insulin Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJ Clin Med.(2020 Jan 21)
  243. HbA1c - Alireza Ostadrahimi, Akbar Taghizadeh, Majid Mobasseri, Nazila Farrin, Laleh Payahoo, Zahra Beyramalipoor Gheshlaghi, Morteza VahedjabbariEffect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trialIran J Public Health.(2015 Feb)
  244. HbA1c - TAREK A. EL-BASHITI, BAKER M. ZABUT and FEDAA F. ABU SAFIAEffect of Probiotic Fermented Milk (Kefir) on Some Blood Biochemical Parameters Among Newly Diagnosed Type 2 Diabetic Adult Males in Gaza GovernorateCurrent Research in Nutrition and Food Science.()
  245. HbA1c - N Cohen, M Halberstam, P Shlimovich, C J Chang, H Shamoon, L RossettiOral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitusJ Clin Invest.(1995 Jun)
  246. HbA1c - Vuksan V, Whitham D, Sievenpiper JL, Jenkins AL, Rogovik AL, Bazinet RP, Vidgen E, Hanna ASupplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trialDiabetes Care.(2007 Nov)
  247. HbA1c - Andersson U, Berger K, Högberg A, Landin-Olsson M, Holm CEffects of rose hip intake on risk markers of type 2 diabetes and cardiovascular disease: a randomized, double-blind, cross-over investigation in obese personsEur J Clin Nutr.(2012 May)
  248. HbA1c - Wu JH, Ward NC, Indrawan AP, Almeida CA, Hodgson JM, Proudfoot JM, Puddey IB, Croft KDEffects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetesClin Chem.(2007 Mar)
  249. Blood glucose - Winterbone MS, Sampson MJ, Saha S, Hughes JC, Hughes DAPro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trialCardiovasc Diabetol.(2007 Feb 22)
  250. DNA Damage - Sampson MJ, Astley S, Richardson T, Willis G, Davies IR, Hughes DA, Southon SIncreased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects of alpha-tocopherol supplementationClin Sci (Lond).(2001 Sep)
  251. Type 2 Diabetes Incidence - Liu S, Lee IM, Song Y, Van Denburgh M, Cook NR, Manson JE, Buring JEVitamin E and risk of type 2 diabetes in the women's health study randomized controlled trialDiabetes.(2006 Oct)
  252. Platelet Aggregation - Clarke MW, Ward NC, Wu JH, Hodgson JM, Puddey IB, Croft KDSupplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetesAm J Clin Nutr.(2006 Jan)
  253. Blood Flow - Gazis A, White DJ, Page SR, Cockcroft JREffect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitusDiabet Med.(1999 Apr)
  254. HbA1c - Barriocanal LA, Palacios M, Benitez G, Benitez S, Jimenez JT, Jimenez N, Rojas VApparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeticsRegul Toxicol Pharmacol.(2008 Jun)
  255. HbA1c - Wainstein J, Ganz T, Boaz M, Bar Dayan Y, Dolev E, Kerem Z, Madar ZOlive leaf extract as a hypoglycemic agent in both human diabetic subjects and in ratsJ Med Food.(2012 Jul)
  256. HbA1c - B. Archimowicz-Cyryłowska, B. Adamek, M. Droździk, L. Samochowiec, J. WójcickiClinical Effect of Buckwheat Herb, Ruscus Extract and Troxerutin on Retinopathy and Lipids in Diabetic PatientsPhytotherapy Research.()
  257. HbA1c - Wang L, Yang H, Huang H, Zhang C, Zuo HX, Xu P, Niu YM, Wu SSInulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.J Transl Med.(2019-Dec-05)
  258. HbA1c - Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law BYK, Xu YEffect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.J Diabetes Res.(2019)
  259. High-density lipoprotein (HDL) - Liu F, Prabhakar M, Ju J, Long H, Zhou HWEffect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials.Eur J Clin Nutr.(2017-Jan)
  260. HbA1c - Shams-Rad S, Mohammadi M, Ramezani-Jolfaie N, Zarei S, Mohsenpour M, Salehi-Abargouei AHesperidin supplementation has no effect on blood glucose control: A systematic review and meta-analysis of randomized controlled clinical trials.Br J Clin Pharmacol.(2020-Jan)
  261. HbA1c - Amirani E, Milajerdi A, Reiner Ž, Mirzaei H, Mansournia MA, Asemi ZEffects of whey protein on glycemic control and serum lipoproteins in patients with metabolic syndrome and related conditions: a systematic review and meta-analysis of randomized controlled clinical trials.Lipids Health Dis.(2020-Sep-21)
  262. Blood glucose - Anders H Frid, Mikael Nilsson, Jens Juul Holst, Inger M E BjörckEffect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjectsAm J Clin Nutr.(2005 Jul)
  263. Blood glucose - Chiang SW, Liu HW, Loh EW, Tam KW, Wang JY, Huang WL, Kuan YCWhey protein supplementation improves postprandial glycemia in persons with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials.Nutr Res.(2022-Aug)
  264. Blood glucose - Smedegaard S, Kampmann U, Ovesen PG, Støvring H, Rittig NWhey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis.Am J Clin Nutr.(2023-Aug)
  265. HbA1c - Xiong K, Wang J, Kang T, Xu F, Ma AEffects of resistant starch on glycaemic control: a systematic review and meta-analysis.Br J Nutr.(2021-Jun-14)
  266. Total Antioxidant Capacity (TAC) - Wei Y, Zhang X, Meng Y, Wang Q, Xu H, Chen LThe Effects of Resistant Starch on Biomarkers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis.Nutr Cancer.(2022)
  267. HbA1c - Zamani M, Ashtary-Larky D, Nosratabadi S, Bagheri R, Wong A, Rafiei MM, Asiabar MM, Khalili P, Asbaghi O, Davoodi SHThe effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis.Phytother Res.(2023-Mar)
  268. HbA1c - Asbaghi O, Ashtary-Larky D, Bagheri R, Moosavian SP, Olyaei HP, Nazarian B, Rezaei Kelishadi M, Wong A, Candow DG, Dutheil F, Suzuki K, Alavi Naeini AFolic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.Nutrients.(2021-Jul-09)
  269. HbA1c - Sudchada P, Saokaew S, Sridetch S, Incampa S, Jaiyen S, Khaithong WEffect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis.Diabetes Res Clin Pract.(2012-Oct)
  270. HbA1c - Ziaei R, Foshati S, Hadi A, Kermani MAH, Ghavami A, Clark CCT, Tarrahi MJThe effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis.Phytother Res.(2020-Feb)
  271. Insulin - Tabrizi R, Sekhavati E, Nowrouzi-Sohrabi P, Rezaei S, Tabari P, Ghoran SH, Jamali N, Jalali M, Moosavi M, Kolahi AA, Bettampadi D, Sahebkar A, Safiri SEffects of on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials.Mini Rev Med Chem.(2022)
  272. Glycemic Control - Namazi N, Esfanjani AT, Heshmati J, Bahrami AThe effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trialPak J Biol Sci.(2011 Aug 1)
  273. Oxidative Stress Biomarkers - Namazi N, Tarighat A, Bahrami AThe effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trialPak J Biol Sci.(2012 Jan 15)
  274. HbA1c - N Suksomboon, N Poolsup, S PunthanitisarnEffect of Aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysisJ Clin Pharm Ther.(2016 Apr)
  275. HbA1c - Shen XL, Zhao T, Zhou Y, Shi X, Zou Y, Zhao GEffect of Oat β-Glucan Intake on Glycaemic Control and Insulin Sensitivity of Diabetic Patients: A Meta-Analysis of Randomized Controlled Trials.Nutrients.(2016 Jan 13)
  276. Blood glucose - Zurbau A, Noronha JC, Khan TA, Sievenpiper JL, Wolever TMSThe effect of oat β-glucan on postprandial blood glucose and insulin responses: a systematic review and meta-analysis.Eur J Clin Nutr.(2021 Nov)
  277. Blood glucose - Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo WEffects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjectsMetabolism.(2007 Jul)
  278. Blood glucose - Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh AThe effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized controlled clinical trialClin Nutr ESPEN.(2019 Oct)
  279. Blood glucose - Johnston CS, Kim CM, Buller AJVinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetesDiabetes Care.(2004 Jan)
  280. Blood glucose - B Andallu, B RadhikaHypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) rootIndian J Exp Biol.(2000 Jun)
  281. Blood glucose - P Agrawal, V Rai, R B SinghRandomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitusInt J Clin Pharmacol Ther.(1996 Sep)
  282. Blood glucose - Hutchison AT, Regmi P, Manoogian ENC, Fleischer JG, Wittert GA, Panda S, Heilbronn LKTime-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover TrialObesity (Silver Spring).(2019 May)
  283. Blood glucose - Losso JN, Holliday DL, Finley JW, Martin RJ, Rood JC, Yu Y, Greenway FLFenugreek bread: a treatment for diabetes mellitusJ Med Food.(2009 Oct)
  284. Blood glucose - Kochhar A, Nagi MEffect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot studyJ Med Food.(2005 Winter)
  285. Glycemic Control - Gupta A, Gupta R, Lal BEffect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled studyJ Assoc Physicians India.(2001 Nov)
  286. Blood glucose - Wedick NM, Brennan AM, Sun Q, Hu FB, Mantzoros CS, van Dam RMEffects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trialNutr J.(2011 Sep 13)
  287. Blood glucose - Muhammad Shoaib Akhtar, Ayesha Ramzan, Amanat Ali, Maqsood AhmadEffect of Amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patientsInt J Food Sci Nutr.(2011 Sep)
  288. Blood glucose - Judy WV, Hari SP, Stogsdill WW, Judy JS, Naguib YM, Passwater RAntidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence studyJ Ethnopharmacol.(2003 Jul)
  289. Blood glucose - Kim JH, Jung WS, Choi NJ, Kim DO, Shin DH, Kim YJHealth-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketonesJ Nutr Biochem.(2009 Apr)
  290. Blood glucose - S Azizi, M Ebrahimi-Mameghani, M Mobasseri, N Karamzad, R MahdaviOxidative stress and nitrate/nitrite (NOx) status following citrulline supplementation in type 2 diabetes: a randomised, double-blind, placebo-controlled trialJ Hum Nutr Diet.(2020 Jul 19)
  291. Blood glucose - Li XS, Zheng WY, Lou SX, Lu XW, Ye SHEffect of Ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathyChin J Integr Med.(2009 Feb)
  292. Blood glucose - Revilla-Monsalve C, Zendejas-Ruiz I, Islas-Andrade S, Báez-Saldaña A, Palomino-Garibay MA, Hernández-Quiróz PM, Fernandez-Mejia CBiotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemiaBiomed Pharmacother.(2006 May)
  293. Blood glucose - Mashhadi NS, Zakerkish M, Mohammadiasl J, Zarei M, Mohammadshahi M, Haghighizadeh MHAstaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitusAsia Pac J Clin Nutr.(2018)
  294. Blood glucose - P. Nazni , T. Poongodi Vijayakumar , P. Alagianambi and M. AmirthaveniHypoglycemic and Hypolipidemic Effect of Cynara Scolymus among Selected Type 2 Diabetic IndividualsPakistan Journal of Nutrition.()
  295. Blood glucose - Felicia William, S. Lakshminarayanan, Hariprasad CheguEffect of some Indian vegetables on the glucose and insulin response in diabetic subjectsInternational Journal of Food Sciences and Nutrition.()
  296. Blood glucose - Zhang R, Noronha JC, Khan TA, McGlynn N, Back S, Grant SM, Kendall CWC, Sievenpiper JLThe Effect of Non-Nutritive Sweetened Beverages on Postprandial Glycemic and Endocrine Responses: A Systematic Review and Network Meta-Analysis.Nutrients.(2023-Feb-20)
  297. Insulin - Santos NC, de Araujo LM, De Luca Canto G, Guerra ENS, Coelho MS, Borin MFMetabolic effects of aspartame in adulthood: A systematic review and meta-analysis of randomized clinical trialsCrit Rev Food Sci Nutr.(2018)
  298. Insulin - Hsu CH, Liao YL, Lin SC, Tsai TH, Huang CJ, Chou PDoes supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trialAltern Med Rev.(2011 Jun)
  299. Insulin - Mousavi SM, Beatriz Pizarro A, Akhgarjand C, Bagheri A, Persad E, Karimi E, Wong A, Jayedi AThe effects of Anethum graveolens (dill) supplementation on lipid profile and glycemic control: a systematic review and meta-analysis of randomized controlled trials.Crit Rev Food Sci Nutr.(2022)
  300. Glycemic Control - Axelsson T, Jansson PA, Smith U, Eliasson BNicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjectsJ Intern Med.(2001 Jun)
  301. Glycemic Control - Gualano B, DE Salles Painneli V, Roschel H, Artioli GG, Neves M Jr, De Sá Pinto AL, Da Silva ME, Cunha MR, Otaduy MC, Leite Cda C, Ferreira JC, Pereira RM, Brum PC, Bonfá E, Lancha AH JrCreatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trialMed Sci Sports Exerc.(2011 May)
  302. Kidney Function - Gualano B, de Salles Painelli V, Roschel H, Lugaresi R, Dorea E, Artioli GG, Lima FR, da Silva ME, Cunha MR, Seguro AC, Shimizu MH, Otaduy MC, Sapienza MT, da Costa Leite C, Bonfá E, Lancha Junior AHCreatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trialEur J Appl Physiol.(2011 May)
  303. Glycemic Control - Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin NEffect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetesFree Radic Biol Med.(2013 Feb 7)
  304. Glycemic Control - Kempf K, Herder C, Erlund I, Kolb H, Martin S, Carstensen M, Koenig W, Sundvall J, Bidel S, Kuha S, Tuomilehto JEffects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trialAm J Clin Nutr.(2010 Apr)
  305. Apolipoprotein A - Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi FEffects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetesJ Altern Complement Med.(2009 Aug)
  306. Blood Pressure - Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam MThe effects of sour tea (Hibiscus sabdariffa) on hypertension in patients with type II diabetesJ Hum Hypertens.(2009 Jan)
  307. Weight - Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F, Cascino A, Rossi-Fanelli FEffects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patientsInt J Obes Relat Metab Disord.(1998 Jul)
  308. High-density lipoprotein (HDL) - Kar P, Laight D, Rooprai HK, Shaw KM, Cummings MEffects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivityDiabet Med.(2009 May)
  309. High-density lipoprotein (HDL) - Alaei-Shahmiri F, Soares MJ, Zhao Y, Sherriff JThe impact of thiamine supplementation on blood pressure, serum lipids and C-reactive protein in individuals with hyperglycemia: a randomised, double-blind cross-over trialDiabetes Metab Syndr.(2015 Oct-Dec)
  310. High-density lipoprotein (HDL) - Li M, He Q, Chen Y, Li B, Feng B, Zhang Z, Wang JXuezhikang Capsule for Type 2 Diabetes with Hyperlipemia: A Systematic Review and Meta-Analysis of Randomized Clinical Trails.Evid Based Complement Alternat Med.(2015)
  311. High-density lipoprotein (HDL) - Sherafati N, Bideshki MV, Behzadi M, Mobarak S, Asadi M, Sadeghi OEffect of supplementation with Chlorella vulgaris on lipid profile in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.Complement Ther Med.(2022-Jun)
  312. Blood Pressure - Ayatollahi SA, Asgary S, Ghanbari F, Karimi R, Kobarfard F, Sarfaraz S, Nazim U, Mohammadi Pour PQuantifying the Impact of Algae Supplement on Blood Pressure: Systematic Review and Meta-analysis of Randomized Controlled Trials.Curr Probl Cardiol.(2022-Nov)
  313. Liver Enzymes - Samira Yarmohammadi, Reza Hosseini-Ghatar, Sahar Foshati, Mojgan Moradi, Niloofar Hemati, Sajjad Moradi, Mohammad Ali Hojjati Kermani, Mohammad Hosein Farzaei, Haroon KhanEffect of Chlorella vulgaris on Liver Function Biomarkers: a Systematic Review and Meta-AnalysisClin Nutr Res.(2021 Jan 29)
  314. Blood Pressure - Akinori Masuda, Masaaki Miyata, Takashi Kihara, Shinichi Minagoe, Chuwa TeiRepeated sauna therapy reduces urinary 8-epi-prostaglandin F(2alpha)Jpn Heart J.(2004 Mar)
  315. Advanced Glycation End Products - Alkhalaf A, Kleefstra N, Groenier KH, Bilo HJ, Gans RO, Heeringa P, Scheijen JL, Schalkwijk CG, Navis GJ, Bakker SJEffect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathyPLoS One.(2012)