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We created brand new FAQs for the THC page! The update includes information about what THC is, how it works, and the potential benefits and risks of using THC.
THC
•Last Updated: April 11, 2024
Delta-9-tetrahydrocannabinol (THC) is the main psychoactive compound found in cannabis, and it is used both recreationally and medicinally. Evidence suggests that THC may reduce neuropathic pain and nausea and vomiting due to chemotherapy. However, THC comes with a laundry list of downsides that must be considered.
THC is most often used for
Last Updated:April 11, 2024
Tetrahydrocannabinol (THC) is a major active cannabinoid in cannabis and is responsible for its psychoactive effects, which lead to changes in mental processes that create the sensation of being "high." It can be found naturally in cannabis or in isolated forms in supplements and prescription medications.
THC (a compound in cannabis) may provide therapeutic benefits for pain relief and reducing chemotherapy-induced nausea and vomiting, and its effects are superior to those of a placebo. However, it can also cause intoxication and other side effects, and its efficacy compared to standard pain relievers remains unclear.
THC's main drawbacks include the potential for dependence, withdrawal symptoms, and a range of side effects such as sedation, dizziness, and impaired cognition, which can increase with higher doses. Additionally, THC use can impair driving ability, and it may pose risks of lung disease when inhaled.
THC works by interacting with the endocannabinoid system; it primarily binds to CB1 receptors in the brain and spinal cord, which alters neurotransmission and affects various bodily functions such as pain signaling and appetite. Additionally, THC activates CB2 receptors in immune cells, which potentially provides anti-inflammatory effects.
Note that THC is also known as:
- tetrahydrocannabinol
- Delta-9-tetrahydrocannabinol
- Δ9-Tetrahydrocannabinol
- Nabilone (THC analog)
- Dronabinol (THC analog)
Isolated THC can be taken orally as an extract in oil, capsule, or edible form. Alternatively, THC can be inhaled through smoking or vaporizing dried cannabis or cannabis concentrates. However, the types of THC available will vary depending on the legal status of THC in your region.
The recommended dosage of THC ranges from 2.5 mg to 30 mg daily. In general, it’s recommended to start low, go slow, and stay low to reduce the risk of side effects and minimize tolerance (a reduced response to the drug after repeated use).[1] This might look like starting at a dose of 2.5–5 mg and increasing slowly (every few days or as tolerated) until the desired therapeutic effect is achieved but side effects are kept to a minimum. If using a prescription medication containing a synthetic version of THC, the dosing may not necessarily be equivalent to natural THC.
THC taken orally will have a slower onset (1–3 hours) than inhaled THC, which has a rapid onset (5–10 minutes).[2]
You can estimate the dose of THC in dried cannabis based on the percent of THC in the product. Simply multiply the total dried weight in milligrams (1 gram = 1,000 milligrams) by the percentage of THC in the product. For example, if you have 0.25 g (250 mg) of dried cannabis with 10% THC, it will contain 25 mg of THC (250 mg x 0.10).
Research FeedRead all studies
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