Vitamin D status and fibromyalgia symptoms in women Original paper

In this cross-sectional study in 68 women with fibromyalgia, there was preliminary evidence that vitamin D status may play a role in managing fibromyalgia symptoms.

This Study Summary was published on April 2, 2025.

The study

Fibromyalgia symptoms were assessed using the Revised Fibromyalgia Impact Questionnaire. Fasting blood samples were analyzed for vitamin D levels, inflammatory markers (e.g., TNF-alpha and interleukin 6), and gut microbiota metabolites (e.g., short-chain fatty acids).

The participants had sufficient vitamin D levels, on average (36 µg/L), which was partly due to supplementation with vitamin D for many participants.

The 37% of participants with insufficient vitamin D levels (<30 µg/L) had higher Revised Fibromyalgia Impact Questionnaire scores (severe symptoms), compared to the participants with sufficient vitamin D levels (moderate symptoms), and higher levels of 1 of 5 inflammatory markers (i.e., interleukin 17) and 1 of 8 gut microbiota metabolites (i.e., [kynurenine-tryptophan ratio|kynurenine) .

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The results

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    This Study Summary was published on April 2, 2025.

    References

    1. ^Jiang X, Zhou R, Zhang Y, Zhu T, Li Q, Zhang WInterleukin-17 as a potential therapeutic target for chronic pain.Front Immunol.(2022)
    2. ^Toghianifar N, Ashtari F, Zarkesh-Esfahani SH, Mansourian MEffect of high dose vitamin D intake on interleukin-17 levels in multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial.J Neuroimmunol.(2015 Aug 15)