Do chia seeds reduce inflammatory biomarkers? Original paper

In this meta-analysis of 4 randomized controlled trials in 210 participants, supplementation with chia seeds had inconsistent effects on inflammatory biomarkers.

This Study Summary was published on March 25, 2025.

The study

All 4 trials were conducted in North America. The participants were men and women with overweight, obesity, or type 2 diabetes. The daily dose of chia seeds was 25 to 50 grams. The intervention duration ranged from 10 to 24 weeks.

Chia seeds reduced (improved) C-reactive protein (−0.64 mg/dL; moderate certainty) but had no effect on interleukin 6 (low certainty) or tumor necrosis factor-alpha (TNF-α; moderate certainty), compared with a placebo.

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The results

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This Study Summary was published on March 25, 2025.

References

  1. ^Del Giudice M, Gangestad SWRethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters.Brain Behav Immun.(2018 May)