Curcumin improves liver enzymes in NAFLD Original paper

In this meta-analysis of 14 randomized controlled trials in 778 men and women (average ages of 41–68) with nonalcoholic fatty liver disease (NAFLD), supplementation with curcumin improved liver enzymes.

This Study Summary was published on March 26, 2025.

Antonis Damianou, MSc

Molly Gregas, PhD

Peter Woznik, ND, MSc

Dashboard

The study

The trials administered curcumin (as curcumin, phytosomal curcumin, nanomicelle curcumin, or phospholipid curcumin), turmeric, or curcuminoids in daily doses of 50 milligrams to 3,000 milligrams. The comparator was a placebo. The intervention duration ranged from 8 to 12 weeks.

Compared to placebo, supplementation with curcumin reduced (improved) alanine aminotransferase by 8.7 IU/L and aspartate aminotransferase by 6.4 IU/L with moderate certainty.

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The results

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This Study Summary was published on March 26, 2025.

References

^M H Ngu, M N Norhayati, Z Rosnani, M M ZulkifliCurcumin as adjuvant treatment in patients with non-alcoholic fatty liver (NAFLD) disease: A systematic review and meta-analysisComplement Ther Med.(2022 Sep)
^Vajdi M, Hassanizadeh S, Hassanizadeh R, Bagherniya MCurcumin supplementation effect on liver enzymes in patients with nonalcoholic fatty liver disease: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.Nutr Rev.(2025 Jan 1)
^Jalali M, Mahmoodi M, Mosallanezhad Z, Jalali R, Imanieh MH, Moosavian SPThe effects of curcumin supplementation on liver function, metabolic profile and body composition in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials.Complement Ther Med.(2020-Jan)