Coffee intake and osteoarthritis risk Original paper

In this Mendelian randomization study in 32,439 adults (average age of 47), coffee intake was associated with an increased risk of developing osteoarthritis.

This Study Summary was published on April 3, 2025.

The study

The authors analyzed data from 10 rounds of the National Health and Nutrition Examination Survey (1999–2018). Participants who were diagnosed with osteoarthritis made up 11% of the sample. Coffee intake was assessed using 24-hour dietary recalls.

In the non-Mendelian randomized analysis, higher coffee intake (over 4 cups per day) was associated with 19% higher odds of osteoarthritis than no coffee intake. The analysis was adjusted for potential confounders, including demographics, health status, and lifestyle factors.

The Mendelian randomization analysis supported the observational results, suggesting increased odds of developing knee (+60%), hip (+80%), or knee and hip (+66%) osteoarthritis when accounting for gene variants that influence coffee intake.

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The results

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    This Study Summary was published on April 3, 2025.

    References

    1. ^Reuter SE, Schultz HB, Ward MB, Grant CL, Paech GM, Banks S, Evans AMThe effect of high-dose, short-term caffeine intake on the renal clearance of calcium, sodium and creatinine in healthy adults.Br J Clin Pharmacol.(2021 Nov)
    2. ^Barger-Lux MJ, Heaney RPCaffeine and the calcium economy revisited.Osteoporos Int.(1995 Mar)
    3. ^Heaney RPEffects of caffeine on bone and the calcium economy.Food Chem Toxicol.(2002 Sep)