Can silymarin improve liver function in chronic liver disease? Original paper

In this 12-week nonrandomized controlled trial in 141 men and women with chronic liver disease, silymarin reduced (improved) the liver enzymes ALT (–33% vs. –19%) and AST (–34% vs. –27%), compared with the control.

This Study Summary was published on April 23, 2025.

The study

The participants in the intervention group took 400 milligrams of silymarin daily and received standard care. The control group received standard care only.

There were no differences between the groups for the primary outcome of liver stiffness (a marker of liver fibrosis severity).

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The results

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This Study Summary was published on April 23, 2025.

References

  1. ^Li S, Duan F, Li S, Lu BAdministration of silymarin in NAFLD/NASH: A systematic review and meta-analysis.Ann Hepatol.(2024 Mar-Apr)