D-Serine
D-Serine is an amino acid that plays a role in cognitive enhancement and schizophrenia treatment.
D-Serine is most often used for
Last Updated:October 13, 2024
D-Serine is an amino acid found in the brain. Derived from glycine, d-serine is a neuromodulator, meaning it regulates the activities of neurons.
D-Serine supplementation can reduce symptoms of cognitive decline. It is also able to reduce symptoms of diseases characterized by reduced N-methyl-D-aspartate (NMDA) signaling, which includes cocaine dependence and schizophrenia.
D-Serine’s effect on schizophrenia is well researched, and though it shows promise, it is also unreliable, since d-serine does not always reach the blood after supplementation. Sarcosine may be a more reliable treatment.
D-Serine is a coagonist at NDMA receptors, which means it improves the effects of other compounds that bind with the receptor. These compounds include glutamate and NMDA itself.
D-Serine is often categorized as a nootropic.
- Glycine or Sarcosine (similar in mechanisms)
- Phosphatidylserine (a phospholipid containing L-serine)
The usual dose used in D-serine studies is 30 mg/kg of bodyweight. This correlates to an approximate dose range of 2,045 – 2,727 mg for people between 150 and 200 lbs. This dose appears to be the minimal effective dose for improving cognition in people suffering from a variety of diseases.
Preliminary evidence suggests that doubling or quadrupling the dose to 60 mg/kg and 120 mg/kg, respectively, will cause additional benefits for people suffering from schizophrenia.
🚧 Under Renovation 🚧
The information in this section is slated for renovation — it will soon be transformed into a more usable (and readable!) form in the coming months. As such, the text in this section may be out of date and not up to Examine’s current standards for writing style.