Hemp Protein
Hemp is a food product derived from the same plant of which Marijuana originates from, but without intoxicating components; the protein fragment appears to be a popular meal replacement supplement but is not yet linked to unique properties (relative to other Protein supplements).
Hemp Protein is most often used for
Last Updated:October 13, 2024
Hemp protein is a industrial byproduct from hempseed where the seeds (balanced macronutrient profile) have their oil extracted into Hempseed oil, and the remainding seedmeal that is high in protein relative to the seeds is then processed into Hemp protein supplements.
Hemp that is currently on the market is a strain low in THC (the intoxicant and psychoactive agent in Marijuana) and does not confer intoxicating properties. It is usually not a pure protein supplement, as it has up to 10% fatty acids by weight (pretty balanced between omega-3 and omega-6 fatty acids and generally high in polyunsaturated fatty acids) and confers a higher inherent fiber content relative to other Protein supplements. The protein portion of hemp is not a complete protein source, due to being low in Lysine (the rate limiting essential amino acid); it is also relatively low in leucine, but is relatively high in both L-Tyrosine and Arginine.
There is a cannabinoid content in Hemp, although they are cannabinoids that do not interact with the two classical cannabinoid receptors in the human body and are unlikely to have the same neural properties attributed to marijuana. These may confer some health properties unique to hemp products (either hempseed protein or Marijuana) but in the context of using hemp protein as a meal replacement they are not studied.
Currently, hemp protein appears to be a viable meal replacement option and has the benefit of having a higher fiber content but is not yet linked to unique health benefits (or harms) to establish its importance over other dietary sources of protein.
- Hemp
- Cannabis sativa
- Hempseed meal
- Marijuana (same plant
- but this refers to variants with a high psychoactive content)
Like any protein supplement, hemp protein supplements are dosed in relation to dietary protein goals and how much dietary protein is consumed via other sources. Protein goals vary from person to person, but a general guide is:
-
If you are an athlete or highly active person currently attempting to lose body fat while preserving lean muscle mass, a daily intake of 1.5-2.2g/kg bodyweight (0.68-1g/lb bodyweight) would be a good target
-
If you are an athlete or highly active person, or you are attempting to lose body fat while preserving lean mass, then a daily intake of 1.0-1.5g/kg bodyweight (0.45-0.68g/lb bodyweight) would be a good target
-
If you are sedentary and not looking to change body composition, a daily target of 0.8g/kg bodyweight (0.36g/lb bodyweight) and upwards would be a good target
Supplementation of hemp protein should be in the dose that is required to meet these ranges after dietary protein has been accounted for. If dietary protein has adequately reached these ranges, then protein supplementation is not required.
Obese individuals (body fat over 20/30% for males and females or a BMI greater than 30 without significant levels of muscle mass) should not follow the above recommendations exactly as the state of obesity would overshoot requirements. In these instances, calculate your targets based upon what your weight would be assuming an overweight BMI.
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To lose more fat and retain more muscle on a weight-loss diet, protein quantity matters more than protein quality.
Losing weight is seldom the goal—losing fat is, while preserving muscle. Unfortunately, your body is reluctant to give up its reserves of energy (its fat) and all too quick to metabolize your hard-earned muscle when the caloric deficit gets just a little too high.
Fortunately, what you eat while on a calorie-restricted diet can affect where the weight loss comes from. Diets high in protein, in particular, have benefits with regard to energy metabolism, appetite, overall caloric intake, and muscle retention.
Appetite and energy metabolism
Protein reduces appetite (and thus food intake) by increasing the levels of certain peptides, such as glucagon-like peptide 1 (GLP-1).[1]
In addition, your body needs to expend 20–30% of the caloric value of protein to metabolize and store it, compared to 5–10% for carbs and just 0–3% for fat.[2][3][4] In other words, the thermic effect of food (TEF) is highest for protein. Whether this makes a practical difference in human beings outside of a clinical setting is a much-debated topic,[5] but diets high in protein have also been shown to mitigate the decline in resting energy expenditure (the calories the body burns at rest) caused by calorie-restricted diets,[6] perhaps because protein promotes muscle retention.[7][8]
A trial randomized 130 overweight people between a high-protein group and a low-protein group. Each day, the high-protein group consumed 1.6 grams of protein per kilogram of body weight (1.6 g/kg, so 0.73 g/lb) and the low-protein group 0.8 g/kg (0.36 g/lb). The trial’s 500 kcal daily deficit led to a weight loss of 9.9–11.2% over a year with no difference between groups, but the high-protein group lost more fat (14.3% ± 11.8%) than the low-protein group (9.3% ± 11.1%), and men more fat than women.[9]
The higher protein intake still benefited women, though, as it did in other trials. When a 10-week trial enrolled 11 obese women to compare a high-protein diet (30% of daily calories as protein) with a high-carb diet (55% of daily calories as carbs), the high-protein diet led to greater weight loss (4.4 kg, so 9.7 lb), most of which was fat (3.7 kg, so 8.2 lb).[10] Relatedly, in a 12-week trial with 100 overweight or obese women, the high-protein and high-carb groups lost the same weight, but the high-protein group lost more fat,[11] which is the same result as in the trial presented in the paragraph above.[9]
Of course, adding exercise can help. In a 16-week trial, 90 overweight or obese women followed the same exercise regimen (aerobic exercise and resistance training) and were randomized to three groups: high protein, high dairy; adequate protein, medium dairy; and adequate protein, low dairy. The first group experienced greater fat loss and muscle gains.[12]
And while the four trials above had enrolled young and/or middle-age women,[9][10][11][12] there’s evidence that postmenopausal women on a calorie-restricted diet also lose less muscle when they eat more protein.[13]
In a 20-week trial, 24 obese postmenopausal women took either 15% or 30% of their daily calories as protein. The 30% group lost less weight (8.4 vs. 11.4 kg, so 18.5 vs. 25.1 lb) but nearly as much fat (7.0 vs. 7.1 kg, so 15.4 vs. 15.7 lb), suggesting greater muscle retention.[14]
Similarly, in a 6-month trial, 31 overweight or obese postmenopausal women (aged 65.2 ± 4.6) were prescribed a diet limited to 1,400 kcal (15% as protein, 65% as carbs, 30% as fat), with one group also taking 50 grams of whey protein twice a day and the other 50 grams of carbs twice a day. The protein group lost more weight (−8.0% ± 6.2%) than the carb group (−4.1% ± 3.6%). The protein group lost more muscle relative to their weight loss, but less muscle relative to their fat loss.[15]
By eating more protein when on a weight-loss diet, you can lose more fat and less muscle.
What is the effect on blood lipids?
In a 12-week weight-loss trial, 100 obese people were randomized to high daily protein (2.2 g/kg, so 1.0 g/lb) or low daily protein (1.1 g/kg, so 0.5 g/lb). Both groups lost the same weight, but here again, the high-protein group lost more fat, and it also experienced reductions in LDL-C and total cholesterol not observed in the low-protein group.[8] In another 12-week weight-loss trial with 215 overweight or obese people, a high-protein diet led to greater reductions in fat, total cholesterol, and triglycerides.[7]
Does the kind of protein matter?
Trials usually control for protein quantity rather than quality, but studies show that proteins with a higher percentage of essential amino acids (EAAs) tend to better correlate with fat loss[16] and bone health.[17] Most EAA-rich proteins are animal proteins: meat, fish, eggs, and dairy. The protein in milk is 80% casein and 20% whey protein.
In general, animal proteins are richer in essential amino acids than plant proteins, and so are better for fat loss, but the advantage is small. For fat loss, protein quantity trumps protein quality.
For more information, see our Optimal Protein Intake Guide and Protein Intake Calculator.
Higher-protein diets augment muscle hypertrophy when combined with resistance training,[18] boost weight loss and mitigate reductions in fat-free mass while dieting,[6] help maintain muscle mass and function with aging,[19] and can improve glycemic control in people with type 2 diabetes.[20][21][22] But must all good things come with downsides? Over the years, some have cautioned that despite its numerous potential benefits, consuming a high-protein diet may also come with long-term health risks, while others have proclaimed that a high-protein diet is outright bad for you. The two most notable criticisms are that a high-protein diet negatively affects bone health and kidney health.
Bone health
The acid-ash hypothesis states the following: The metabolism of certain foods — namely protein and grains — increases acid production in the body, as evidenced by an increase in urinary acidity.[23] To counteract this increase in acidity, bone is broken down to release calcium bicarbonate (a base) corresponding with an increase in urinary calcium excretion, which is thought to reflect negative body calcium balance or bone loss. Therefore, a high-protein or acid-producing diet accelerates bone loss and increases the risk of osteoporosis.
However, changes in urine pH don’t necessarily reflect changes in blood pH, which is maintained within a narrow range primarily by the renal and pulmonary systems in healthy people.[24] Additionally, variations in diet have virtually no effect on blood pH, as any nutritional influence that slightly disrupts acid-base balance is immediately corrected by biochemical buffering systems that do not involve bone.[24]
While an increase in urinary acidity has been correlated with an increase in urinary calcium excretion, dietary changes that increase urinary acidity do not lower body calcium balance.[25] Relatedly, a higher-protein diet does not negatively affect dietary calcium retention because although it increases urinary calcium excretion, it increases intestinal calcium absorption by a similar magnitude.[26][27]
Ultimately, the available evidence does not support the acid-ash hypothesis,[28] and in accordance, higher-protein diets do not have a negative effect on bone health.
Meta-analyses of prospective cohort studies have reported that a higher-protein diet was either not associated with the risk of hip fracture,[29] or, compared to the group with the lowest protein intake, there was an 11%–16% lower risk of hip fracture in the group with the highest protein intake.[30][31][32]
With respect to bone mineral density (BMD), a meta-analysis of randomized controlled trials 12–24 months long reported that a higher-protein diet had a protective effect on lumbar spine BMD.[33] A higher-protein diet also tended to have a protective effect on total hip BMD, although this finding was not statistically significant. The data from prospective cohort studies is mixed on whether higher-protein diets have a protective effect on BMD (some studies suggest a benefit with more protein, while others have reported no impact), but there is a lack of evidence indicating that higher-protein diets are associated with lower BMD.[31][33]
Concerning protein intakes significantly greater than the Recommended Dietary Allowance (RDA), there are a couple of long-term prospective cohort studies in older adults that shed light on the topic. In one four-year study that included older men and women (average age of 75), the quartile with the highest protein intake (1.24–2.78 grams of protein per kg of body weight per day) showed the least BMD loss at the femur and lumbar spine.[34] Compared to the quartile with the highest protein intake, the quartiles with the lowest (0.21–0.71 g/kg/day) and second-lowest (0.72–0.96 g/kg/day) protein intakes experienced a significant reduction in femoral neck BMD.
In a separate five-year cohort study that only included older women (average age of 75), a higher protein intake was associated with greater whole-body bone mineral content, and the tertile with the highest protein intake (about 1.6 g/kg/d) had significantly higher whole-body and appendicular bone mineral content than the tertiles with lower intakes.[35]
Kidney health
The idea that a high-protein diet puts undue stress on the kidneys stems from early research in rodents and dogs that reported increased urea excretion, renal blood flow, glomerular filtration rate (GFR; a marker of kidney function), and kidney size in animals fed a high-protein diet.[36] From this data, it was determined that a high-protein diet increases the workload of the kidneys, and thus may damage the kidneys over time and increase the risk of chronic kidney disease (CKD).
A 2018 meta-analysis of randomized controlled trials that compared the effects of a high-protein diet (1.8 grams of protein per kilogram of body weight per day, on average) to a low-protein diet (0.93 g/kg/d) in healthy adults reported that higher protein intakes may slightly increase GFR.[37] Other data indicates that a high-protein diet does not adversely affect blood markers of kidney function or blood pressure.[38][39]
Given these findings, a high-protein diet does not appear to pose a serious threat to kidney health. In further support of this conclusion, the issue at hand can be viewed through a different lens altogether; that is, is an increase in GFR a risk factor for CKD in healthy people? Such a relationship has yet to be clearly established.[37]
In fact, an increase in GFR in response to an increase in solute load (e.g., nitrogen from protein) is a normal adaptive mechanism.[40] For example, GFR can increase by as much as 65% during pregnancy[41] but does not increase the risk of CKD.[42] Also, surgical removal of a kidney is not associated with a deterioration in kidney function in the long term (> 20 years), despite the increase in workload.[43][44][45]
While a low-protein diet is recommended for people with CKD to help prevent disease progression,[46] this does not mean that a high-protein diet is harmful in all cases. The available evidence suggests that, in healthy people, a high-protein diet does not adversely affect kidney function or increase the risk of CKD.
Several scales have been developed to rate proteins according to their respective bioavailabilities and, more recently, amino acid profiles. Those scales can help guide your choice of protein, as long as you understand their premises and limitations.
Nutrition sure can seem complicated. You already had to worry about getting enough protein in your diet, should you now make sure you only get quality proteins?
And what makes a “quality protein” anyway?
Different scales have been developed to answer this last question. They rate and rank proteins based on two criteria: bioavailability and amino acid profile.
Bioavailability
Biological Value (BV), Net Protein Utilisation (NPU), and Nitrogen Balance (NB) rate proteins based on nitrogen measurements. They measure how much nitrogen people excreted, calculate how much protein that represents, and compare this number to how much protein was ingested. In such a way, they determine the protein’s bioavailability.
All three scales are based on two assumptions, both of which have been challenged: first, that dietary protein is the body’s sole source of nitrogen; second, that all nonexcreted protein has been used to make bodily proteins. In truth, some of the protein we ingest can be converted to glucose, especially if the protein’s digestion is fast and the body’s glycogen stores are low, and some can be fermented by our microbiota,[47] especially if the protein’s digestion is slow.
The BV scale is still in use today, though mostly in promotional material and in the media, and so it needed mentioning despite being outdated. The current official scale, used notably by the FDA, is the Protein Digestibility Corrected Amino Acid Score (PDCAAS), which takes into account not just the bioavailability of a protein but also its amino acid profile.
A protein is considered highly bioavailable if it’s easy to digest, absorb, and (after conversion into its constituent amino acids) make into other proteins. Some protein rating scales, such as the BV scale, rank proteins based solely on bioavailability.
Amino acid profile
Proteins are composed of amino acids, some of which your body can synthesize and others not. The nine you need yet cannot synthesize, and thus need to ingest, are called essential amino acids (EAAs). Among those, branched-chain amino acids (BCAAs) are crucial to your muscles,[48] with leucine being especially anabolic.
Essential Amino Acid (EAA) | mg/kg/day | Complete | Milk | Pea | Rice | Soy | Whey |
---|---|---|---|---|---|---|---|
Leucine (BCAA)
|
39
|
59
|
97
|
97
|
88
|
80
|
116
|
Isoleucine (BCAA)
|
20
|
30
|
50
|
54
|
40
|
43
|
59
|
Valine (BCAA)
|
26
|
39
|
58
|
81
|
55
|
44
|
58
|
Cystine
|
4
|
6
|
9
|
14
|
17
|
12
|
20
|
Histidine
|
10
|
15
|
30
|
17
|
24
|
26
|
21
|
Lysine
|
30
|
45
|
80
|
83
|
33
|
60
|
102
|
Methionine
|
10
|
16
|
27
|
5
|
29
|
10
|
23
|
Methionine + cysteine
|
15
|
22
|
30
|
8
|
39
|
14
|
36
|
Phenylalanine + tyrosine
|
25
|
30
|
99
|
94
|
111
|
90
|
66
|
Threonine
|
15
|
23
|
47
|
43
|
38
|
37
|
76
|
Tryptophan
|
4
|
6
|
13
|
11
|
14
|
13
|
20
|
mg/kg/day = daily requirement in milligrams (of a given amino acid) per kilogram (of body weight) per day
Complete/Milk/Pea/Rice/Soy/Whey = milligrams of amino acid per gram of complete/milk/pea/rice/soy/whey protein (mg/g)
References: World Health Organization. Protein and Amino Acid Requirements in Human Nutrition, page 245, table 49. 2007.[49] Kalman. Foods. 2014.[50] Gorissen et al. Amino Acids. 2018.[51] USDA Food Composition Databases (accessed: 2018 Sep)
A protein is called complete when, proportionally to its overall amino-acid content, it has enough of each EAA. The main advantage of animal proteins is that most are complete.
Most, but not all. Take beef protein powders: you might assume they’re made from meat, which is to say from the animal’s muscles, when most are actually made from collagen boiled from the animal’s skin, bones, and other connective tissues. Now, dietary collagen is far from useless; it’s been shown to promote skin and joint health, and it probably promotes bone health too; but it isn’t a complete protein.[52] Rich in glycine and proline but poor in BCAAs, it isn’t a good primary source of protein, and is probably not the best muscle builder (though it has shown benefit in elderly women on a low-protein diet[53] and in elderly men[54]).
Conversely, most plant proteins are incomplete, but according to the table above, the proteins in soy, pea, and rice are nearly complete: rice is relatively poor in lysine; soy and pea, in methionine. Of course, incomplete proteins can complement one another — this is true of proteins from foods as well as from supplements. The amino acid profile of a 70:30 pea:rice protein blend is similar to that of whey.
Alas, soy and pea protein powders are usually very high in salt. Salt is used in the process that makes soy and pea protein powders, and it cannot all be washed away. Check the label of your soy or pea protein powder to ensure you don’t end up exceeding your tolerable upper intake of salt (sodium) for the day: 2.3 g for most adults.
Although pea and rice are gaining in popularity, alone and in combination, soy is still the most popular vegan source of protein powder. On the Protein Digestibility-Corrected Amino Acid Score (PDCAAS) scale, soy protein isolates scores 0.97 (97%), so at first glance it appears to be the virtual equals of any animal protein. However, this is because the PDCAAS scale truncates any number superior to 1 (100%), with the rationale that any amount of amino acids beyond the requirement pattern confers no additional benefit to the individual consuming the protein. Otherwise, whey protein concentrate could score a more-than-perfect 1.07 (107%).[55]
A dietary protein is considered complete if it contains enough of each of the amino acids your body needs yet cannot synthesize. Some protein rating scales, such as the PDCAAS scale, rank proteins based not just on bioavailability but also on amino acid profile.
The real world
The PDCAAS scale has displaced the BV scale, not because it is more accurate, but because it is more pertinent: it rates protein not only based on bioavailability but also on amino acid profile, so as to better reflect human needs. Better, but not perfectly, which is why the Food and Agriculture Organization has already proposed to replace it with yet another scale: the Digestible Indispensable Amino Acid Score (DIAAS).
The two scales differ notably by where the sample is taken. To determine the PDCAAS of a protein, you analyze the feces. To determine the DIAAS of a protein, you analyze the content of the ileum. In other words, PDCAAS looks at how much protein was absorbed after it has gone through your small and large intestines, whereas DIAAS looks at how much protein was absorbed after it has left the small intestine.
The food you ingest passes through your small intestine before passing through your large intestine, where most of your gut’s microbiome (the bacteria inhabiting your gut) can be found. Since this microbiome can use amino acids and peptides that you yourselves never absorbed, PDCAAS may overestimate a protein’s bioavailability.[55] DIAAS overcomes this issue.
Protein powder | PDCAAS | DIAAS |
---|---|---|
Milk protein concentrate
|
121
|
120
|
Whey protein concentrate
|
107
|
107
|
Whey protein isolate
|
97
|
100
|
Soy protein isolate
|
86
|
84
|
Pea protein concentrate
|
71
|
62
|
DIAAS = Digestible Indispensable Amino Acid Score | PDCAAS = Protein Digestibility-Corrected Amino Acid Score
Reference: Mathai et al. Br J Nutr. 2017.[55]
The DIAAS scale, however, doesn’t address the main problem of all protein rating scales, which is that, even when they take into account bioavailability, amino acid profile, and ileal digestibility, and even if they took into account gluconeogenesis, digestion speed, and the effects of exercise on endogenous protein (i.e., muscles), they would still fail to reflect real life.
Trials need to eliminate confusing factors, so a subject is fed only one kind of protein, and that on an empty stomach. But when do you eat only one kind of protein over a whole day? And, except at breakfast maybe, when is your stomach really empty? Other food components, such as fiber and anti-nutrients (trypsin inhibitors, tannins, etc.), can all affect how much of your protein you absorb.
Rating each protein in isolation fails to reflect real life. You don’t need each protein you ingest to be complete; in a balanced diet, incomplete proteins, rich and poor in different amino acids, can complement one another (especially when eaten at about the same time). But a protein’s rating can be one of the criteria you consider when selecting a protein powder (alongside price, mixability, digestion speed, etc.).
🚧 Under Renovation 🚧
The information in this section is slated for renovation — it will soon be transformed into a more usable (and readable!) form in the coming months. As such, the text in this section may be out of date and not up to Examine’s current standards for writing style.
- ^C Verdich, A Flint, J P Gutzwiller, E Näslund, C Beglinger, P M Hellström, S J Long, L M Morgan, J J Holst, A AstrupA meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humansJ Clin Endocrinol Metab.(2001 Sep)
- ^M S Westerterp-Plantenga, A Nieuwenhuizen, D Tomé, S Soenen, K R WesterterpDietary protein, weight loss, and weight maintenanceAnnu Rev Nutr.(2009)
- ^Halton TL, Hu FBThe effects of high protein diets on thermogenesis, satiety and weight loss: a critical reviewJ Am Coll Nutr.(2004 Oct)
- ^Tappy LThermic effect of food and sympathetic nervous system activity in humansReprod Nutr Dev.(1996)
- ^Leidy HJ, Clifton PM, Astrup A, Wycherley TP, Westerterp-Plantenga MS, Luscombe-Marsh ND, Woods SC, Mattes RDThe role of protein in weight loss and maintenanceAm J Clin Nutr.(2015 Jun)
- ^Wycherley TP, Moran LJ, Clifton PM, Noakes M, Brinkworth GDEffects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trialsAm J Clin Nutr.(2012 Dec)
- ^P M Clifton, K Bastiaans, J B KeoghHigh protein diets decrease total and abdominal fat and improve CVD risk profile in overweight and obese men and women with elevated triacylglycerolNutr Metab Cardiovasc Dis.(2009 Oct)
- ^Leo Treyzon, Steve Chen, Kurt Hong, Eric Yan, Catherine L Carpenter, Gail Thames, Susan Bowerman, He-Jing Wang, Robert Elashoff, Zhaoping LiA controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body massNutr J.(2008 Aug 27)
- ^Ellen M Evans, Mina C Mojtahedi, Matthew P Thorpe, Rudy J Valentine, Penny M Kris-Etherton, Donald K LaymanEffects of protein intake and gender on body composition changes: a randomized clinical weight loss trialNutr Metab (Lond).(2012 Jun 12)
- ^Idoia Labayen, Nieves Díez, Alvaro González, Dolores Parra, J Alfredo MartínezEffects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight lossForum Nutr.(2003)
- ^Noakes M, Keogh JB, Foster PR, Clifton PMEffect of an energy-restricted, high-protein, low-fat diet relative to a conventional high-carbohydrate, low-fat diet on weight loss, body composition, nutritional status, and markers of cardiovascular health in obese womenAm J Clin Nutr.(2005 Jun)
- ^Andrea R Josse, Stephanie A Atkinson, Mark A Tarnopolsky, Stuart M PhillipsIncreased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal womenJ Nutr.(2011 Sep)
- ^Melanie J Bopp, Denise K Houston, Leon Lenchik, Linda Easter, Stephen B Kritchevsky, Barbara J NicklasLean mass loss is associated with low protein intake during dietary-induced weight loss in postmenopausal womenJ Am Diet Assoc.(2008 Jul)
- ^M M Gordon, M J Bopp, L Easter, G D Miller, M F Lyles, D K Houston, B J Nicklas, S B KritchevskyEffects of dietary protein on the composition of weight loss in post-menopausal womenJ Nutr Health Aging.(2008 Oct)
- ^Mojtahedi MC, Thorpe MP, Karampinos DC, Johnson CL, Layman DK, Georgiadis JG, Evans EMThe effects of a higher protein intake during energy restriction on changes in body composition and physical function in older womenJ Gerontol A Biol Sci Med Sci.(2011 Nov)
- ^Jeremy P Loenneke, Jacob M Wilson, Anssi H Manninen, Mandy E Wray, Jeremy T Barnes, Thomas J PujolQuality protein intake is inversely related with abdominal fatNutr Metab (Lond).(2012 Jan 27)
- ^Jeremy P Loenneke, Abhishek Balapur, Austin D Thrower, Georganne Syler, Maureen Timlin, Thomas J PujolShort report: Relationship between quality protein, lean mass and bone healthAnn Nutr Metab.(2010)
- ^Morton RW, Murphy KT, McKellar SR, Schoenfeld BJ, Henselmans M, Helms E, Aragon AA, Devries MC, Banfield L, Krieger JW, Phillips SMA systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adultsBr J Sports Med.(2018 Mar)
- ^Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, Phillips S, Sieber C, Stehle P, Teta D, Visvanathan R, Volpi E, Boirie YEvidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study GroupJ Am Med Dir Assoc.(2013 Aug)
- ^Silva Ton WT, das Graças de Almeida C, de Morais Cardoso L, Marvila Girondoli Y, Feliciano Pereira P, Viana Gomes Schitini JK, Galvão Cândido F, Marques Arbex P, de Cássia Gonçalves Alfenas REffect of different protein types on second meal postprandial glycaemia in normal weight and normoglycemic subjects.Nutr Hosp.(2014-Mar-01)
- ^Mary C Gannon, Frank Q Nuttall, Asad Saeed, Kelly Jordan, Heidi HooverAn increase in dietary protein improves the blood glucose response in persons with type 2 diabetesAm J Clin Nutr.(2003 Oct)
- ^Mads J Skytte, Amirsalar Samkani, Amy D Petersen, Mads N Thomsen, Arne Astrup, Elizaveta Chabanova, Jan Frystyk, Jens J Holst, Henrik S Thomsen, Sten Madsbad, Thomas M Larsen, Steen B Haugaard, Thure KrarupA carbohydrate-reduced high-protein diet improves HbA 1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trialDiabetologia.(2019 Nov)
- ^Buclin T, Cosma M, Appenzeller M, Jacquet AF, Décosterd LA, Biollaz J, Burckhardt PDiet acids and alkalis influence calcium retention in boneOsteoporos Int.(2001)
- ^Bonjour JPNutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney.Br J Nutr.(2013-Oct)
- ^Fenton TR, Lyon AW, Eliasziw M, Tough SC, Hanley DAMeta-analysis of the effect of the acid-ash hypothesis of osteoporosis on calcium balanceJ Bone Miner Res.(2009 Nov)
- ^Hunt JR, Johnson LK, Fariba Roughead ZKDietary protein and calcium interact to influence calcium retention: a controlled feeding studyAm J Clin Nutr.(2009 May)
- ^Kerstetter JE, O'Brien KO, Caseria DM, Wall DE, Insogna KLThe impact of dietary protein on calcium absorption and kinetic measures of bone turnover in womenJ Clin Endocrinol Metab.(2005 Jan)
- ^Fenton TR, Tough SC, Lyon AW, Eliasziw M, Hanley DACausal assessment of dietary acid load and bone disease: a systematic review & meta-analysis applying Hill's epidemiologic criteria for causalityNutr J.(2011 Apr 30)
- ^Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SADietary protein and bone health: a systematic review and meta-analysis.Am J Clin Nutr.(2009-Dec)
- ^Wu AM, Sun XL, Lv QB, Zhou Y, Xia DD, Xu HZ, Huang QS, Chi YLThe relationship between dietary protein consumption and risk of fracture: a subgroup and dose-response meta-analysis of prospective cohort studies.Sci Rep.(2015-Mar-16)
- ^Taylor C Wallace, Cara L FrankenfeldDietary Protein Intake above the Current RDA and Bone Health: A Systematic Review and Meta-AnalysisJ Am Coll Nutr.(2017 Aug)
- ^Inge Groenendijk, Laura den Boeft, Luc J C van Loon, Lisette C P G M de GrootHigh Versus low Dietary Protein Intake and Bone Health in Older Adults: a Systematic Review and Meta-AnalysisComput Struct Biotechnol J.(2019 Jul 22)
- ^Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Wallace TC, Weaver CMDietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis FoundationAm J Clin Nutr.(2017 Jun)
- ^Hannan MT, Tucker KL, Dawson-Hughes B, Cupples LA, Felson DT, Kiel DPEffect of dietary protein on bone loss in elderly men and women: the Framingham Osteoporosis Study.J Bone Miner Res.(2000-Dec)
- ^Xingqiong Meng, Kun Zhu, Amanda Devine, Deborah A Kerr, Colin W Binns, Richard L PrinceA 5-year cohort study of the effects of high protein intake on lean mass and BMC in elderly postmenopausal womenJ Bone Miner Res.(2009 Nov)
- ^Brenner BM, Meyer TW, Hostetter THDietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal diseaseN Engl J Med.(1982 Sep 9)
- ^Devries MC, Sithamparapillai A, Brimble KS, Banfield L, Morton RW, Phillips SMChanges in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-AnalysisJ Nutr.(2018 Nov 1)
- ^Mary E Van Elswyk, Charli A Weatherford, Shalene H McNeillA Systematic Review of Renal Health in Healthy Individuals Associated with Protein Intake above the US Recommended Daily Allowance in Randomized Controlled Trials and Observational StudiesAdv Nutr.(2018 Jul 1)
- ^Rebholz CM, Friedman EE, Powers LJ, Arroyave WD, He J, Kelly TNDietary protein intake and blood pressure: a meta-analysis of randomized controlled trialsAm J Epidemiol.(2012 Oct 1)
- ^Martin WF, Armstrong LE, Rodriguez NRDietary protein intake and renal function.Nutr Metab (Lond).(2005-Sep-20)
- ^Conrad KPMechanisms of renal vasodilation and hyperfiltration during pregnancy.J Soc Gynecol Investig.(2004-Oct)
- ^Cortinovis M, Perico N, Ruggenenti P, Remuzzi A, Remuzzi GGlomerular hyperfiltration.Nat Rev Nephrol.(2022-07)
- ^Regazzoni BM, Genton N, Pelet J, Drukker A, Guignard JPLong-term followup of renal functional reserve capacity after unilateral nephrectomy in childhood.J Urol.(1998-Sep)
- ^Higashihara E, Horie S, Takeuchi T, Nutahara K, Aso YLong-term consequence of nephrectomy.J Urol.(1990-Feb)
- ^Goldfarb DA, Matin SF, Braun WE, Schreiber MJ, Mastroianni B, Papajcik D, Rolin HA, Flechner S, Goormastic M, Novick ACRenal outcome 25 years after donor nephrectomy.J Urol.(2001-Dec)
- ^Ikizler TA, Burrowes JD, Byham-Gray LD, Campbell KL, Carrero JJ, Chan W, Fouque D, Friedman AN, Ghaddar S, Goldstein-Fuchs DJ, Kaysen GA, Kopple JD, Teta D, Yee-Moon Wang A, Cuppari LKDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update.Am J Kidney Dis.(2020-09)
- ^Macfarlane GT, Macfarlane SBacteria, colonic fermentation, and gastrointestinal healthJ AOAC Int.(2012 Jan-Feb)
- ^MacLean DA, Graham TE, Saltin BBranched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exerciseAm J Physiol.(1994 Dec)
- ^Joint WHO/FAO/UNU Expert ConsultationProtein and Amino Acid Requirements in Human NutritionWorld Health Organ Tech Rep Ser.(2007)
- ^Douglas S KalmanAmino Acid Composition of an Organic Brown Rice Protein Concentrate and Isolate Compared to Soy and Whey Concentrates and IsolatesFoods.(2014 Jun 30)
- ^Stefan H M Gorissen, Julie J R Crombag, Joan M G Senden, W A Huub Waterval, Jörgen Bierau, Lex B Verdijk, Luc J C van LoonProtein Content and Amino Acid Composition of Commercially Available Plant-Based Protein IsolatesAmino Acids.(2018 Dec)
- ^EASTOE JEThe amino acid composition of mammalian collagen and gelatinBiochem J.(1955 Dec)
- ^Hays NP, Kim H, Wells AM, Kajkenova O, Evans WJEffects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older womenJ Am Diet Assoc.(2009 Jun)
- ^Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, König DCollagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trialBr J Nutr.(2015 Oct 28)
- ^Mathai JK, Liu Y, Stein HHValues for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS)Br J Nutr.(2017 Feb)
- Low-density lipoprotein (LDL) - Ursula S Schwab, James C Callaway, Arja T Erkkilä, Jukka Gynther, Matti I J Uusitupa, Tomi JärvinenEffects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factorsEur J Nutr.(2006 Dec)
- Low-density lipoprotein (LDL) - Kaul N, Kreml R, Austria JA, Richard MN, Edel AL, Dibrov E, Hirono S, Zettler ME, Pierce GNA comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteersJ Am Coll Nutr.(2008 Feb)
- Skin Quality - Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, Järvinen TEfficacy of dietary hempseed oil in patients with atopic dermatitisJ Dermatolog Treat.(2005 Apr)