Inositol

Last Updated: August 14, 2023

Inositol can improve insulin sensitivity and glycemic control, and may help manage polycystic ovary syndrome (PCOS) and prevent gestational diabetes. The most commonly supplemented forms of inositol are myo-inositol and D-chiro-inositol, but all forms are interchangeably referred to as inositol.

Inositol is most often used for

What is inositol?

Inositol refers to a group of glucose-like molecules involved in cellular signaling that are synthesized in the body and obtained from dietary sources such as citrus fruits, bran, beans, nuts, and seeds. Inositol is commonly taken as a dietary supplement, primarily in the myo-inositol form, which is the most abundant type in the body.

What are inositol’s main benefits?

Inositol supplementation may enhance insulin sensitivity and potentially aid in the prevention and treatment of diabetes, particularly gestational diabetes, and shows promise for managing polycystic ovary syndrome (PCOS). Additionally, it may support weight loss and improve cardiovascular health by reducing blood pressure and cholesterol levels, though further high-quality research is needed to confirm these benefits.

What are inositol’s main drawbacks?

Inositol's main drawbacks include a lack of comprehensive studies on the safety and side effects of orally administered inositol, which means that its side effects are not clearly defined. Although side effects are generally uncommon, high doses (up to 12 grams per day) can lead to gastrointestinal issues such as nausea and diarrhea.

How does inositol work?

Inositols are naturally occurring molecules in the body that play a role in cellular signaling, particularly in blood glucose control through their influence on insulin signaling and sensitivity. However, further research is necessary to fully elucidate their mechanisms of action.

What are other names for Inositol?
Note that Inositol is also known as:
  • Myoinositol
  • Cyclohexanehexol
  • 6-cyclohexanehexol
  • 1 2 3 4 5 6-cyclohexanehexol
Inositol should not be confused with:
  • D-pinitol (structurally related)
Dosage information

Studies finding beneficial effects of inositol on gestational diabetes or polycystic ovary syndrome typically administer myo-inositol in the range of 1–4 grams (1000–4000 milligrams) once daily.

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References
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Examine Database References
  1. Weight - M Nordio, E ProiettiThe combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation aloneEur Rev Med Pharmacol Sci.(2012 May)
  2. Weight - Gerli S, Papaleo E, Ferrari A, Di Renzo GCRandomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOSEur Rev Med Pharmacol Sci.(2007 Sep-Oct)
  3. Weight - Gerli S, Mignosa M, Di Renzo GCEffects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trialEur Rev Med Pharmacol Sci.(2003 Nov-Dec)
  4. Weight - Alessandro D Genazzani, Alessia Prati, Susanna Santagni, Federica Ricchieri, Elisa Chierchia, Erica Rattighieri, Annalisa Campedelli, Tommaso Simoncini, Paolo G ArtiniDifferential insulin response to myo-inositol administration in obese polycystic ovary syndrome patientsGynecol Endocrinol.(2012 Dec)
  5. Weight - Donà G, Sabbadin C, Fiore C, Bragadin M, Giorgino FL, Ragazzi E, Clari G, Bordin L, Armanini DInositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndromeEur J Endocrinol.(2012 Apr)
  6. Glycemic Control - Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, Ferrari AEfficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndromeGynecol Endocrinol.(2009 Aug)
  7. Glycemic Control - Costantino D, Minozzi G, Minozzi E, Guaraldi CMetabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trialEur Rev Med Pharmacol Sci.(2009 Mar-Apr)
  8. Glycemic Control - Iuorno MJ, Jakubowicz DJ, Baillargeon JP, Dillon P, Gunn RD, Allan G, Nestler JEEffects of d-chiro-inositol in lean women with the polycystic ovary syndromeEndocr Pract.(2002 Nov-Dec)
  9. Glycemic Control - Genazzani AD, Lanzoni C, Ricchieri F, Jasonni VMMyo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndromeGynecol Endocrinol.(2008 Mar)
  10. Glycemic Control - Miñambres I, Cuixart G, Gonçalves A, Corcoy REffects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trialsClin Nutr.(2019 Jun)
  11. Fertility - Papaleo E, Unfer V, Baillargeon JP, Fusi F, Occhi F, De Santis LMyo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trialFertil Steril.(2009 May)
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  16. Blood glucose - Greff D, Juhász AE, Váncsa S, Váradi A, Sipos Z, Szinte J, Park S, Hegyi P, Nyirády P, Ács N, Várbíró S, Horváth EMInositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.Reprod Biol Endocrinol.(2023-Jan-26)
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  22. Excessive Hair Growth - Minozzi M, D'Andrea G, Unfer VTreatment of hirsutism with myo-inositol: a prospective clinical studyReprod Biomed Online.(2008 Oct)
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  28. Depression Symptoms - Tomohiko Mukai, Taro Kishi, Yuki Matsuda, Nakao IwataA meta-analysis of inositol for depression and anxiety disordersHum Psychopharmacol.(2014 Jan)
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  30. Glycemic Control - Wei J, Yan J, Yang HInositol Nutritional Supplementation for the Prevention of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients.(2022-Jul-09)
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  32. Blood glucose - Brown J, Crawford TJ, Alsweiler J, Crowther CADietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes.Cochrane Database Syst Rev.(2016-Sep-07)
  33. Alzheimer's Disease Symptoms - Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, Cedarbaum JM, ELND005-AD201 InvestigatorsA phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer diseaseNeurology.(2011 Sep 27)
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  37. Schizophrenia symptoms - Levine J, Goldberger I, Rapaport A, Schwartz M, Schield C, Elizur A, Belmaker RH, Shapiro J, Agam GCSF inositol in schizophrenia and high-dose inositol treatment of schizophreniaEur Neuropsychopharmacol.(1994 Dec)
  38. Anxiety Symptoms - Palatnik A, Frolov K, Fux M, Benjamin JDouble-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorderJ Clin Psychopharmacol.(2001 Jun)
  39. Anxiety Symptoms - Benjamin J, Levine J, Fux M, Aviv A, Levy D, Belmaker RHDouble-blind, placebo-controlled, crossover trial of inositol treatment for panic disorderAm J Psychiatry.(1995 Jul)
  40. Panic Attacks - Benjamin J, Nemetz H, Fux M, Bleichman I, Agam GAcute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorderJ Psychiatr Res.(1997 Jul-Aug)
  41. Depression Symptoms - Gianfranco C, Vittorio U, Silvia B, Francesco DMyo-inositol in the treatment of premenstrual dysphoric disorderHum Psychopharmacol.(2011 Oct)
  42. PMS Symptoms - Nemets B, Talesnick B, Belmaker RH, Levine JMyo-inositol has no beneficial effect on premenstrual dysphoric disorderWorld J Biol Psychiatry.(2002 Jul)
  43. Bipolar Disorder Symptoms - Chengappa KN, Levine J, Gershon S, Mallinger AG, Hardan A, Vagnucci A, Pollock B, Luther J, Buttenfield J, Verfaille S, Kupfer DJInositol as an add-on treatment for bipolar depressionBipolar Disord.(2000 Mar)
  44. Autism Symptoms - Levine J, Aviram A, Holan A, Ring A, Barak Y, Belmaker RHInositol treatment of autismJ Neural Transm.(1997)
  45. OCD Symptoms - Fux M, Levine J, Aviv A, Belmaker RHInositol treatment of obsessive-compulsive disorderAm J Psychiatry.(1996 Sep)
  46. Post-Traumatic Stress Disorder Symptoms - Kaplan Z, Amir M, Swartz M, Levine JInositol treatment of post-traumatic stress disorderAnxiety.(1996)
  47. Forgetting - Levine J, Pomerantz T, Stier S, Belmaker RHLack of effect of 6 g inositol treatment of post-ECT cognitive function in humansJ Psychiatr Res.(1995 Nov-Dec)
  48. Psoriasis Symptoms - Allan SJ, Kavanagh GM, Herd RM, Savin JAThe effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trialBr J Dermatol.(2004 May)
  49. Triglycerides - Tabrizi R, Ostadmohammadi V, Lankarani KB, Peymani P, Akbari M, Kolahdooz F, Asemi ZThe effects of inositol supplementation on lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials.Lipids Health Dis.(2018-May-24)
  50. Retinal Function - Du Y, He Y, Wang YL, Zhou JG, Chen CThe efficacy and safety of inositol supplementation in preterm infants to prevent retinopathy of prematurity: a systematic review and meta-analysis.BMC Ophthalmol.(2019-Jun-25)
  51. Thyroid-Stimulating Hormone - Zuhair V, Sheikh AT, Shafi N, Babar A, Khan A, Sadiq A, Ashraf MA, Nihan K, Hamza M, Khalid B, Haya Fatima S, Arshad MA, Ali ERole of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.Clin Med Insights Endocrinol Diabetes.(2024)