Inulin

Last Updated: November 2, 2023

Inulin is a type of soluble fiber that can be taken as a supplement or found naturally in foods (e.g., Jerusalem artichokes, chicory, asparagus, garlic, onions, wheat, bananas). Inulin can have prebiotic effects on the gut microbiome, leading to increases in the abundance of potentially beneficial bacteria, such as Bifidobacterium spp.. Inulin may have various benefits on gut and overall health, but clinical trials tend to report inconsistent results, which may be due to variability in baseline microbiomes, habitual diets, and health status.

Inulin is most often used for

What is inulin?

Inulin is a soluble dietary fiber and fructan carbohydrate that is made up of chains of fructose molecules; it is found naturally in various plants and serves as an energy storage form. It is resistant to human digestion and reaches the large intestine, where it acts as a food source for gut microbes and promotes the production of beneficial compounds and the growth of healthy bacteria.

What are inulin’s main benefits?

Inulin primarily benefits gut health by promoting the growth of beneficial bacteria like Bifidobacterium and may also improve blood sugar regulation, reduce LDL cholesterol, enhance satiety, and improve bowel movement frequency. However, the effects vary between studies and are generally small in magnitude.

What are inulin’s main drawbacks?

Inulin is generally safe, but it can cause gastrointestinal side effects like bloating, gas, and diarrhea, especially at higher doses or with short-chain forms due to faster fermentation. Starting with a lower dose and gradually increasing intake may help improve tolerance, though individual responses can vary due to gut microbiome differences.

How does inulin work?

Inulin functions primarily as a fermentable fiber; it influences the gut microbiome and promotes the production of bioactive metabolites like short-chain fatty acids (SCFAs), which may improve health. However, clinical trials have yielded mixed results on SCFA production, and establishing a direct association between gut microbiome changes and beneficial health outcomes in humans remains challenging.

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Update History
2023-11-02 00:30:03

A few new meta-analyses added

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We found a few more meta-analyses on inulin that we added to our database.

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References
  1. ^Qin YQ, Wang LY, Yang XY, Xu YJ, Fan G, Fan YG, Ren JN, An Q, Li XInulin: properties and health benefits.Food Funct.(2023-Apr-03)
  2. ^Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law BYK, Xu YEffect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.J Diabetes Res.(2019)
  3. ^Hughes RL, Alvarado DA, Swanson KS, Holscher HDThe Prebiotic Potential of Inulin-Type Fructans: A Systematic Review.Adv Nutr.(2022-Mar)
  4. ^Sheng W, Ji G, Zhang LImmunomodulatory effects of inulin and its intestinal metabolites.Front Immunol.(2023)
  5. ^Ribeiro MC, Levi Y, Moraschini V, Messora MR, Furlaneto FACEffects of Prebiotic Therapy on Gastrointestinal Microbiome of Individuals with Different Inflammatory Conditions: A Systematic Review of Randomized Controlled Trials.Probiotics Antimicrob Proteins.(2023-Apr-24)
  6. ^Wang L, Yang H, Huang H, Zhang C, Zuo HX, Xu P, Niu YM, Wu SSInulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.J Transl Med.(2019-Dec-05)
  7. ^Liu F, Prabhakar M, Ju J, Long H, Zhou HWEffect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials.Eur J Clin Nutr.(2017-Jan)
  8. ^Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, Calle-Purón ME, Hernández Cabria MEffectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials.Nutr Hosp.(2014-Aug-01)
  9. ^Watson AW, Houghton D, Avery PJ, Stewart C, Vaughan EE, Meyer PD, de Bos Kuil MJJ, Weijs PJM, Brandt KChanges in stool frequency following chicory inulin consumption, and effects on stool consistency, quality of life and composition of gut microbiota.Food Hydrocoll.(2019-Nov)
  10. ^Dayanne da Silva Borges, Ricardo Fernandes, Arthur Thives Mello, Ethiene da Silva Fontoura, Adair Roberto Soares Dos Santos, Erasmo Benicio Santos de Moraes TrindadePrebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysisNutr Rev.(2020 Mar 1)
  11. ^Bonnema AL, Kolberg LW, Thomas W, Slavin JLGastrointestinal tolerance of chicory inulin products.J Am Diet Assoc.(2010-Jun)
  12. ^Singh V, Yeoh BS, Chassaing B, Xiao X, Saha P, Aguilera Olvera R, Lapek JD, Zhang L, Wang WB, Hao S, Flythe MD, Gonzalez DJ, Cani PD, Conejo-Garcia JR, Xiong N, Kennett MJ, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar MDysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer.Cell.(2018-Oct-18)
  13. ^An L, Yang JC, Yin H, Xue R, Wang Q, Sun YC, Zhang YZ, Yang MInulin-Type Oligosaccharides Extracted from Yacon Produce Antidepressant-Like Effects in Behavioral Models of Depression.Phytother Res.(2016-Dec)
  14. ^Wang L, Wang Z, Lan Y, Tuo Y, Ma S, Liu XInulin Attenuates Blood-Brain Barrier Permeability and Alleviates Behavioral Disorders by Modulating the TLR4/MyD88/NF-κB Pathway in Mice with Chronic Stress.J Agric Food Chem.(2023-Sep-13)
  15. ^Richard T Liu, Rachel F L Walsh, Ana E SheehanPrebiotics and probiotics for depression and anxiety: A systematic review and meta-analysis of controlled clinical trialsNeurosci Biobehav Rev.(2019 Jul)
  16. ^Quentin Leyrolle, Renata Cserjesi, Maria D G H Mulders, Giorgia Zamariola, Sophie Hiel, Marco A Gianfrancesco, Daphné Portheault, Camille Amadieu, Laure B Bindels, Sophie Leclercq, Julie Rodriguez, Audrey M Neyrinck, Patrice D Cani, Nicolas Lanthier, Pierre Trefois, Jérome Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M DelzennePrebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trialBrain Behav Immun.(2021 Jan 27)
  17. ^Jackson PP, Wijeyesekera A, Williams CM, Theis S, van Harsselaar J, Rastall RAInulin-type fructans and 2'fucosyllactose alter both microbial composition and appear to alleviate stress-induced mood state in a working population compared to placebo (maltodextrin): the EFFICAD Trial, a randomized, controlled trial.Am J Clin Nutr.(2023-Aug-30)
  18. ^Liber A, Szajewska HEffects of inulin-type fructans on appetite, energy intake, and body weight in children and adults: systematic review of randomized controlled trials.Ann Nutr Metab.(2013)
Examine Database References
  1. Blood glucose - Wang L, Yang H, Huang H, Zhang C, Zuo HX, Xu P, Niu YM, Wu SSInulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.J Transl Med.(2019-Dec-05)
  2. Blood glucose - Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law BYK, Xu YEffect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis.J Diabetes Res.(2019)
  3. Low-density lipoprotein (LDL) - Liu F, Prabhakar M, Ju J, Long H, Zhou HWEffect of inulin-type fructans on blood lipid profile and glucose level: a systematic review and meta-analysis of randomized controlled trials.Eur J Clin Nutr.(2017-Jan)
  4. C-Reactive Protein (CRP) - Dayanne da Silva Borges, Ricardo Fernandes, Arthur Thives Mello, Ethiene da Silva Fontoura, Adair Roberto Soares Dos Santos, Erasmo Benicio Santos de Moraes TrindadePrebiotics may reduce serum concentrations of C-reactive protein and ghrelin in overweight and obese adults: a systematic review and meta-analysisNutr Rev.(2020 Mar 1)
  5. Constipation Signs and Symptoms - Collado Yurrita L, San Mauro Martín I, Ciudad-Cabañas MJ, Calle-Purón ME, Hernández Cabria MEffectiveness of inulin intake on indicators of chronic constipation; a meta-analysis of controlled randomized clinical trials.Nutr Hosp.(2014-Aug-01)
  6. Bifidobacterium Abundance - Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu JEffect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis.Nutrients.(2022-Aug-12)
  7. Migraine Frequency - Vajdi M, Khorvash F, Askari GA randomized, double-blind, placebo-controlled parallel trial to test the effect of inulin supplementation on migraine headache characteristics, quality of life and mental health symptoms in women with migraine.Food Funct.(2024 Sep 30)
  8. Liver Fat - Mayengbam S, Raman M, Parnell JA, Eksteen B, Lambert JE, Eller LK, Nicolucci AC, Aktary ML, Reimer RAEffects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial.Eur J Nutr.(2025 Apr 2)