Honey

Last Updated: November 5, 2024

Honey is a sweet, thick liquid with antibacterial properties that can promote the growth of epithelial tissue like skin. It has been studied for oral mucositis from cancer treatment, wounds and burns, cough, and other conditions.

Honey is most often used for

What is honey?

Honey is created from flower nectar and secretions from the upper digestive tract of the honey bee. It is composed mostly of carbohydrates, though it also contains some free amino acids, vitamins, trace elements, and polyphenols.[7] It has been used for wound healing for thousands of years.[8][9]

What are honey’s main benefits?
What are honey’s main drawbacks?

Honey should not be given to infants under 12 months of age. This is because honey can contain Clostridium botulinum (the bacterium that causes botulism), and infants less than 12 months of age have poor immunity against this bacterium.[16][20]

Because honey is primarily composed of sugar, researchers have wondered if it could negatively affect weight or metabolic health. However, meta-analyses of RCTs have found moderate-quality evidence that honey had no effect on blood lipids (LDL-C, HDL-C)[21] or ALT.[22] Furthermore, a 2023 meta-analysis of RCTs found a beneficial effect on blood lipids (reduced total cholesterol and triglycerides; low-quality evidence). Some studies even found reductions to fasting glucose (low-quality evidence)[6] and weight (moderate-quality evidence).[23]

How does honey work?

Honey has antibacterial, antiviral, antifungal, and anti-inflammatory properties.[7][16][24][25][26][27][28][29] Specifically, honey may work through a variety of factors, such as hydrogen peroxide, non-peroxides, nitric oxide, polyphenols, a high osmolality (strongly drawing water out of the cells of bacteria), and its acidity.[30][31]

Honey contains less-commonly found sugars, such as allulose, tagatose, and isomaltulose, which have been associated with improvements in cardiometabolic risk factors.[32][33]

What are other names for Honey?
Note that Honey is also known as:
  • Raw honey
  • Unpasteurized honey
  • Manuka honey
  • Medihoney
Honey should not be confused with:
  • Propolis
  • Royal jelly
Dosage information

In oral mucositis, many studies used a dose of 20 mL (approximately 1 tablespoon) of honey swallowed before and after radiation therapy.[1]

For cough in children, doses of 5–10 mL (approximately 1–2 teaspoons), for example, in 90 mL of milk, have been studied.[2]

For skin, a majority of studies applied honey topically to the affected areas.[3][4][5]

A 2023 meta-analysis of 18 RCTs which examined honey for metabolic health did not find a dose-response effect for any outcomes, except the improvements of systolic blood pressure were not as large when the dose was over 10% of daily total calories (50–62 grams for people eating 2,000–2,500 calories per day). In other words, higher dosages did not increase or decrease the effectiveness of honey for improving metabolic outcomes in some studies. The researchers in this meta-analysis did note that they examined studies which used honey at doses of 5–125 grams, with a median dose of 40 grams (approximately 3 tablespoons).[6]

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Update History
2024-11-05 00:30:04

All new FAQs were added to this page.

major

All new FAQs were added to this page including "What are honey's main benefits?" showing that honey has the strongest evidence to help oral mucositis, a potentially serious side effect of the treatment of head and neck cancers.

Honey has also been used to treat skin conditions such as wounds, burns, diabetic foot ulcers, canker sores, and herpes sores. Even more diversely, honey may also help improve acute cough and dry eye.

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References
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  2. ^Miceli Sopo S, Greco M, Monaco S, Varrasi G, Di Lorenzo G, Simeone G, Milk Honey Study (M&HS) GroupEffect of multiple honey doses on non-specific acute cough in children. An open randomised study and literature review.Allergol Immunopathol (Madr).(2015 Sep-Oct)
  3. ^Norman G, Dumville JC, Mohapatra DP, Owens GL, Crosbie EJAntibiotics and antiseptics for surgical wounds healing by secondary intention.Cochrane Database Syst Rev.(2016 Mar 29)
  4. ^Norman G, Dumville JC, Moore ZE, Tanner J, Christie J, Goto SAntibiotics and antiseptics for pressure ulcers.Cochrane Database Syst Rev.(2016 Apr 4)
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  6. ^Amna Ahmed, Zujaja Tul-Noor, Danielle Lee, Shamaila Bajwah, Zara Ahmed, Shanza Zafar, Maliha Syeda, Fakeha Jamil, Faizaan Qureshi, Fatima Zia, Rumsha Baig, Saniya Ahmed, Mobushra Tayyiba, Suleman Ahmad, Dan Ramdath, Rong Tsao, Steve Cui, Cyril W C Kendall, Russell J de Souza, Tauseef A Khan, John L SievenpiperEffect of honey on cardiometabolic risk factors: a systematic review and meta-analysisNutr Rev.(2022 Nov 16)
  7. ^Yang C, Gong G, Jin E, Han X, Zhuo Y, Yang S, Song B, Zhang Y, Piao CTopical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis.Int J Nurs Stud.(2019 Jan)
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  14. ^Li S, Xiao T, Ye N, Yang G, Chen H, Liang X, Li T, Wang J, Peng Y, Li Y, Liu YEffect of honey dressing in the management of diabetic foot ulcers: A meta-analysis.Int Wound J.(2023 Sep)
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  31. ^Ferraz Barbosa B, de Moraes FCA, Araujo Alves da Silva B, Bordignon Barbosa C, Pereira da Silva I, da Silva ER, Barros JCM, Rebouças LWC, Dos Santos NPC, Fernandes MRThe Use of Honey for Cicatrization and Pain Control of Obstetric Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients.(2024-Jan-05)
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  33. ^Braunstein CR, Noronha JC, Khan TA, Mejia SB, Wolever TM, Josse RG, Kendall CW, Sievenpiper JLEffect of fructose and its epimers on postprandial carbohydrate metabolism: A systematic review and meta-analysis.Clin Nutr.(2020 Nov)
  34. ^Andriakopoulou CS, Yapijakis C, Koutelekos I, Perdikaris PPrevention and Treatment of Oral Mucositis in Pediatric Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials.In Vivo.(2024 May-Jun)
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  36. ^Xu JL, Xia R, Sun ZH, Sun L, Min X, Liu C, Zhang H, Zhu YMEffects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials.Int J Oral Maxillofac Surg.(2016 Dec)
  37. ^Co JL, Mejia MB, Que JC, Dizon JMEffectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature.Head Neck.(2016 Jul)
  38. ^Tian X, Xu L, Liu X, Wang CC, Xie W, Jiménez-Herrera MF, Chen WImpact of honey on radiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis.Ann Palliat Med.(2020 Jul)
  39. ^Raza A, Karimyan N, Watters A, Emperumal CP, Al-Eryani K, Enciso REfficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.Support Care Cancer.(2022 Nov)
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Examine Database References
  1. Cough - Kuitunen I, Renko MHoney for acute cough in children - a systematic review.Eur J Pediatr.(2023-Jun-25)
  2. Fatigue Symptoms - Sun X, Chen Y, Cheung WK, Wu IX, Xiao F, Chung VCPharmacological Interventions for the Management of Cancer-Related Fatigue Among Cancer Survivors: Systematic Review and Meta-Analysis.Integr Cancer Ther.(2021 Jan-Dec)
  3. Mucositis Symptoms - Lee CC, Chen YW, Kang YN, Chen JH, Chen C, Lu CY, Huang TW, Gautama MSNEfficacy of natural products in preventing oral mucositis resulting from cancer therapies: A network meta-analysis of randomized controlled trials.Crit Rev Oncol Hematol.(2024 Jul)
  4. Canker Sores Symptoms - Liu H, Tan L, Fu G, Chen L, Tan HEfficacy of Topical Intervention for Recurrent Aphthous Stomatitis: A Network Meta-Analysis.Medicina (Kaunas).(2022 Jun 7)
  5. Wound Healing - Wang C, Guo M, Zhang N, Wang GEffectiveness of honey dressing in the treatment of diabetic foot ulcers: A systematic review and meta-analysis.Complement Ther Clin Pract.(2019 Feb)
  6. Wound Healing - Yildiz Karadeniz E, Kaplan Serin EUse of honey in diabetic foot ulcer: Systematic review and meta-analysis.J Tissue Viability.(2023 May)
  7. Dry Eye Symptoms - Hu J, Kong L, Zhu S, Ju M, Zhang QEfficacy and safety of manuka honey for dry eye.Clin Exp Optom.(2023 Jul)
  8. Total cholesterol - Gholami Z, Sohrabi Z, Zare M, Pourrajab B, Nasimi NThe effect of honey on lipid profiles: a systematic review and meta-analysis of controlled clinical trials.Br J Nutr.(2022 May 28)
  9. Blood glucose - Amna Ahmed, Zujaja Tul-Noor, Danielle Lee, Shamaila Bajwah, Zara Ahmed, Shanza Zafar, Maliha Syeda, Fakeha Jamil, Faizaan Qureshi, Fatima Zia, Rumsha Baig, Saniya Ahmed, Mobushra Tayyiba, Suleman Ahmad, Dan Ramdath, Rong Tsao, Steve Cui, Cyril W C Kendall, Russell J de Souza, Tauseef A Khan, John L SievenpiperEffect of honey on cardiometabolic risk factors: a systematic review and meta-analysisNutr Rev.(2022 Nov 16)
  10. Risk Of Cardiovascular Disease - Semnani-Azad Z, Khan TA, Blanco Mejia S, de Souza RJ, Leiter LA, Kendall CWC, Hanley AJ, Sievenpiper JLAssociation of Major Food Sources of Fructose-Containing Sugars With Incident Metabolic Syndrome: A Systematic Review and Meta-analysis.JAMA Netw Open.(2020 Jul 1)
  11. Length of hospitalization - Andriakopoulou CS, Yapijakis C, Koutelekos I, Perdikaris PPrevention and Treatment of Oral Mucositis in Pediatric Patients: Systematic Review and Meta-Analysis of Randomized Controlled Trials.In Vivo.(2024 May-Jun)
  12. Mucositis Symptoms - Xu JL, Xia R, Sun ZH, Sun L, Min X, Liu C, Zhang H, Zhu YMEffects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials.Int J Oral Maxillofac Surg.(2016 Dec)
  13. Mucositis Symptoms - Co JL, Mejia MB, Que JC, Dizon JMEffectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature.Head Neck.(2016 Jul)
  14. Mucositis Symptoms - Liu TM, Luo YW, Tam KW, Lin CC, Huang TWProphylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials.Support Care Cancer.(2019 Jul)
  15. Mucositis Symptoms - Tian X, Xu L, Liu X, Wang CC, Xie W, Jiménez-Herrera MF, Chen WImpact of honey on radiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis.Ann Palliat Med.(2020 Jul)
  16. Mucositis Symptoms - An W , Li S , Qin L Role of honey in preventing radiation-induced oral mucositis: a meta-analysis of randomized controlled trials.Food Funct.(2021 Apr 21)
  17. Mucositis Symptoms - Lima ICGDS, de Fátima Souto Maior L, Gueiros LAM, Leão JC, Higino JS, Carvalho AATClinical applicability of natural products for prevention and treatment of oral mucositis: a systematic review and meta-analysis.Clin Oral Investig.(2021 Jun)
  18. Mucositis Symptoms - Raza A, Karimyan N, Watters A, Emperumal CP, Al-Eryani K, Enciso REfficacy of oral and topical antioxidants in the prevention and management of oral mucositis in head and neck cancer patients: a systematic review and meta-analyses.Support Care Cancer.(2022 Nov)
  19. Mucositis Symptoms - Yang C, Gong G, Jin E, Han X, Zhuo Y, Yang S, Song B, Zhang Y, Piao CTopical application of honey in the management of chemo/radiotherapy-induced oral mucositis: A systematic review and network meta-analysis.Int J Nurs Stud.(2019 Jan)
  20. Mucositis Symptoms - Yu YT, Deng JL, Jin XR, Zhang ZZ, Zhang XH, Zhou XEffects of 9 oral care solutions on the prevention of oral mucositis: a network meta-analysis of randomized controlled trials.Medicine (Baltimore).(2020 Apr)
  21. Liver Enzymes - Lee D, Chiavaroli L, Ayoub-Charette S, Khan TA, Zurbau A, Au-Yeung F, Cheung A, Liu Q, Qi X, Ahmed A, Choo VL, Blanco Mejia S, Malik VS, El-Sohemy A, de Souza RJ, Wolever TMS, Leiter LA, Kendall CWC, Jenkins DJA, Sievenpiper JLImportant Food Sources of Fructose-Containing Sugars and Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Controlled Trials.Nutrients.(2022-Jul-12)
  22. Weight - Chiavaroli L, Cheung A, Ayoub-Charette S, Ahmed A, Lee D, Au-Yeung F, Qi X, Back S, McGlynn N, Ha V, Lai E, Khan TA, Blanco Mejia S, Zurbau A, Choo VL, de Souza RJ, Wolever TM, Leiter LA, Kendall CW, Jenkins DJ, Sievenpiper JLImportant food sources of fructose-containing sugars and adiposity: A systematic review and meta-analysis of controlled feeding trials.Am J Clin Nutr.(2023 Apr)
  23. Wound Healing - Ferraz Barbosa B, de Moraes FCA, Araujo Alves da Silva B, Bordignon Barbosa C, Pereira da Silva I, da Silva ER, Barros JCM, Rebouças LWC, Dos Santos NPC, Fernandes MRThe Use of Honey for Cicatrization and Pain Control of Obstetric Wounds: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients.(2024-Jan-05)
  24. Upper Respiratory Tract Infection Symptoms - Hibatullah Abuelgasim, Charlotte Albury, Joseph LeeEffectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysisBMJ Evid Based Med.(2020 Aug 18)
  25. Wound Healing - Hwang SH, Song JN, Jeong YM, Lee YJ, Kang JMThe efficacy of honey for ameliorating pain after tonsillectomy: a meta-analysis.Eur Arch Otorhinolaryngol.(2016 Apr)
  26. Wound Healing - Zhang F, Chen Z, Su F, Zhang TComparison of topical honey and povidone iodine-based dressings for wound healing: a systematic review and meta-analysis.J Wound Care.(2021 Apr 1)
  27. Wound Healing - Norman G, Dumville JC, Moore ZE, Tanner J, Christie J, Goto SAntibiotics and antiseptics for pressure ulcers.Cochrane Database Syst Rev.(2016 Apr 4)
  28. Wound Healing - Norman G, Christie J, Liu Z, Westby MJ, Jefferies JM, Hudson T, Edwards J, Mohapatra DP, Hassan IA, Dumville JCAntiseptics for burns.Cochrane Database Syst Rev.(2017 Jul 12)
  29. Cold Sore Symptom Duration - Rocha MP, Amorim JM, Lima WG, Brito JCM, da Cruz Nizer WSEffect of honey and propolis, compared to acyclovir, against Herpes Simplex Virus (HSV)-induced lesions: A systematic review and meta-analysis.J Ethnopharmacol.(2022 Apr 6)