In this 12-week randomized controlled trial in 56 participants with diabetic retinopathy, supplementing with curcumin and piperine did not affect disease severity, but there were improvements in oxidative stress biomarkers.
Quick Summary
In this 12-week randomized controlled trial in 56 participants with diabetic retinopathy, supplementing with curcumin and piperine did not affect disease severity, but there were improvements in oxidative stress biomarkers.
The study
The participants supplemented with either 1,000 milligrams of curcumin and 10 milligrams of piperine or a placebo daily.
Compared to the placebo group, total antioxidant capacity and superoxide dismutase activity increased and malondialdehyde decreased in the curcumin group.
The severity of diabetic retinopathy was determined by the density and thickness of the small blood vessels in the retina, which was assessed using optical coherence tomography angiography.
All of the analyses were adjusted for baseline levels.
The results
The results should be interpreted with caution because the researchers did not adjust for multiple comparisons. Also, the change from baseline was only statistically significant for 1 of 3 oxidative stress biomarkers in the curcumin group, which suggests that the effect of the intervention was relatively small.
A previous study that used a different measurement technique and evaluated different metrics for the severity of diabetic retinopathy reported benefits from curcumin supplementation,[1] so further research is needed.
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Quick Summary
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The study
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The results
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Note
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The big picture
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What was studied?
Whether curcumin, with or without piperine, improved symptoms of inflammatory bowel disease (IBD).
The primary outcome was superoxide dismutase activity, an oxidative stress biomarker. The secondary outcomes were 4 other oxidative stress biomarkers (e.g., malondialdehyde), 5 inflammatory biomarkers (e.g., fecal calprotectin), 9 gastrointestinal symptoms (e.g., heartburn), and BMI.
How was it studied?
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What was studied?
The effect of a curcumin and piperine supplement on fasting glucose, insulin resistance, and BMI in the context of prediabetes or type 2 diabetes (T2D).
How was it studied?
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What was studied?
The effect of supplementing with piperine on cardiometabolic risk factors in participants with nonalcoholic fatty liver disease (NAFLD).
The primary outcomes were changes in levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
The secondary outcomes were alkaline phosphatase (a liver enzyme), bilirubin, blood lipids, fasting glucose, fecal calprotectin, gamma-glutamyl transferase (a liver enzyme), HbA1c, HOMA-IR, and serum albumin.
How was it studied?
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