2024-03-18 16:53:25
Fixed an error in the dosage section
correction
In the dosage section, we said "methanol" instead of "ethanol" when describing the preparation of stinging nettle used for the treatment of benign prostatic hyperplasia.
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Stinging Nettle
•Last Updated: February 10, 2024
Stinging nettle (Urtica dioica) is a perennial plant that can cause painful reactions when it comes in contact with the skin. It has been used for many years as a medicinal vegetable in the treatment of pain, bleeding, urinary tract diseases, and allergies.
Stinging Nettle is most often used for
Last Updated:February 10, 2024
Stinging nettle, or Urtica dioica, is a tall green plant from the Urticaceae family and is characterized by its needle-like trichomes that inject irritating chemicals into the skin. Despite its painful effects when touched, all parts of the plant have medicinal uses once processed to deactivate the toxins.
Stinging nettle is primarily used to treat benign prostatic hyperplasia by potentially reducing prostate size and improving urinary symptoms, and it may also help with urinary tract disorders and kidney stones. Additionally, it has been studied for its analgesic and anti-inflammatory properties in arthritis, its effects on blood sugar levels in diabetes, and its potential in cancer prevention and treatment, though more clinical trials are needed to confirm these benefits.
Stinging nettle supplements can cause minor gastrointestinal issues and have been associated with more serious effects such as severe hypoglycemia, gynecomastia, and galactorrhea. Additionally, they may affect the cytochrome P450 enzyme system and potentially interfere with the metabolism of certain medications.
Stinging nettle contains phenolic compounds that contribute to its various health effects, including disrupting cell proliferation in benign prostatic hyperplasia, lowering the absorption of sugar in the intestines, reducing inflammation, and providing antioxidant properties. Additionally, it may alleviate asthma and allergy symptoms by blocking histamine receptors and decreasing cytokine release.
Note that Stinging Nettle is also known as:
- Urtica dioica
- Radix Urticae
- Common Nettle
- Greater Nettle
- Ortica
- Tsuknida
For allergic rhinitis, the recommended dosage is 600 mg of dried nettle leaf per day taken in three separate doses.[1]
In benign prostatic hyperplasia (BPH), a daily dose of 360 mg of aqueous root extract taken as 3 divided doses is suggested for up to 6 months.[2] Alternatively, methanol root extract of up to 1,200 mg daily, also as three divided doses, can be used for up to 9 weeks.[3] While these doses are used in trials, there is no clear evidence-based dose as yet, and there are wide variations in the doses used for the other potential benefits.
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2024-02-10 00:30:03
Full page update
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New meta-analyses were added to the database. FAQs were added and updated with detailed information from recent studies. New information was added for stinging nettle use in diabetes and neurodegenerative disorders.
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- ^Safarinejad MRUrtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover studyJ Herb Pharmacother.(2005)
- ^WHO monographs on selected medicinal plants, volume 2(2002)
- ^Blum F, Hager C, Taufik H, Wiesmann M, Hasan D, Reich A, Pinho J, Nikoubashman OSeeing the good in the bad: actual clinical outcome of thrombectomy stroke patients with formally unfavorable outcome.Neuroradiology.(2022 Jul)
- ^Esposito S, Bianco A, Russo R, Di Maro A, Isernia C, Pedone PVTherapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment.Molecules.(2019 Jul 29)
- ^The efficacy and safety of Urtica dioica in treating benign prostatic hyperplasia: a systematic review and meta-analysisAfr J Tradit Complement Altern Med.(2016)
- ^Wilt TJ, Ishani A, Rutks I, MacDonald RPhytotherapy for benign prostatic hyperplasia.Public Health Nutr.(2000 Dec)
- ^Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, Bishayee ADietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.Int J Mol Sci.(2018 Mar 7)
- ^Zhang H, Li N, Li K, Li PProtective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats.Mol Med Rep.(2014 Dec)
- ^Dhouibi R, Affes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda KScreening of pharmacological uses of Urtica dioica and others benefits.Prog Biophys Mol Biol.(2020 Jan)
- ^Stinging nettles leaf (Urtica dioica L.): Extraordinary Vegetable medicine(2013)
- ^The Effectiveness and Application of *Urtica dioica* (Stinging Nettle) for Musculoskeletal disorders: A Systematic Review and Meta-Analysis(2023-02)
- ^Tabrizi R, Sekhavati E, Nowrouzi-Sohrabi P, Rezaei S, Tabari P, Ghoran SH, Jamali N, Jalali M, Moosavi M, Kolahi AA, Bettampadi D, Sahebkar A, Safiri SEffects of on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials.Mini Rev Med Chem.(2022)
- ^Ziaei R, Foshati S, Hadi A, Kermani MAH, Ghavami A, Clark CCT, Tarrahi MJThe effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis.Phytother Res.(2020-Feb)
- ^Mehdi Bakhshaee, Amir Hooshang Mohammad Pour, Majid Esmaeili, Farahzad Jabbari Azad, Ghazal Alipour Talesh, Maryam Salehi, Morteza Noorollahian MohajerEfficacy of Supportive Therapy of Allergic Rhinitis by Stinging Nettle (Urtica dioica) root extract: a Randomized, Double-Blind, Placebo- Controlled, Clinical TrialIran J Pharm Res.(2017 Winter)
- ^Barisic D, Diether D, Maichle-Mössmer C, Anwander RTrimethylscandium.J Am Chem Soc.(2019 Sep 4)
- ^Ghasemi S, Moradzadeh M, Mousavi SH, Sadeghnia HRCytotoxic effects of Urtica dioica radix on human colon (HT29) and gastric (MKN45) cancer cells mediated through oxidative and apoptotic mechanisms.Cell Mol Biol (Noisy-le-grand).(2016 Oct 15)
- ^Mohammadi A, Mansoori B, Aghapour M, Baradaran PC, Shajari N, Davudian S, Salehi S, Baradaran BThe Herbal Medicine Utrica Dioica Inhibits Proliferation of Colorectal Cancer Cell Line by Inducing Apoptosis and Arrest at the G2/M Phase.J Gastrointest Cancer.(2016 Jun)
- ^Mohammadi A, Mansoori B, Goldar S, Shanehbandi D, Khaze V, Mohammadnejad L, Baghbani E, Baradaran BEffects of Urtica dioica dichloromethane extract on cell apoptosis and related gene expression in human breast cancer cell line (MDA-MB-468).Cell Mol Biol (Noisy-le-grand).(2016 Feb 29)
- ^Karakol P, Saraydin SU, Bozkurt M, Hepokur C, Inan ZDS, Turan MAnticancer Effects of Urtica Dioica in Breast Cancer.Asian Pac J Cancer Prev.(2022 Feb 1)
- ^Telo S, Halifeoglu I, Ozercan IHEffects of Stinging Nettle (Urtica Dioica L.,) on Antioxidant Enzyme Activities in Rat Model of Mammary Gland Cancer.Iran J Pharm Res.(2017 Winter)
- ^Mohammadi A, Mansoori B, Baradaran PC, Khaze V, Aghapour M, Farhadi M, Baradaran BUrtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo.Clin Breast Cancer.(2017 Oct)
- ^Mohammadi A, Mansoori B, Aghapour M, Shirjang S, Nami S, Baradaran BThe Urtica dioica extract enhances sensitivity of paclitaxel drug to MDA-MB-468 breast cancer cells.Biomed Pharmacother.(2016 Oct)
- ^Nafeh G, Abi Akl M, Samarani J, Bahous R, Al Kari G, Younes M, Sarkis R, Rizk SUrtica dioica Leaf Infusion Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Cisplatin Treatment.Pharmaceuticals (Basel).(2023 May 23)
- ^Hodroj MH, Al Bast NAH, Taleb RI, Borjac J, Rizk SNettle Tea Inhibits Growth of Acute Myeloid Leukemia Cells In Vitro by Promoting Apoptosis.Nutrients.(2020 Aug 28)
- ^Wang C, Li MY, Shen XH, Wang SJ, Wang WQ, Liu YFEffect of CDK1 Interferes with the Regulation of PLK1, Aurora B and TRF1 on the Proliferation of Leukemia Cells.Zhongguo Shi Yan Xue Ye Xue Za Zhi.(2021 Aug)
- ^Cipil HS, Kosar A, Kaya A, Uz B, Haznedaroglu IC, Goker H, Ozdemir O, Koroglu M, Kirazli S, Firat HCIn vivo hemostatic effect of the medicinal plant extract Ankaferd Blood Stopper in rats pretreated with warfarin.Clin Appl Thromb Hemost.(2009 May-Jun)
- ^Baykul T, Alanoglu EG, Kocer GUse of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience.J Contemp Dent Pract.(2010 Jan 1)
- ^Edgcumbe DP, McAuley DHypoglycaemia related to ingestion of a herbal remedy.Eur J Emerg Med.(2008 Aug)
- ^Sahin M, Yilmaz H, Gursoy A, Demirel AN, Tutuncu NB, Guvener NDGynaecomastia in a man and hyperoestrogenism in a woman due to ingestion of nettle (Urtica dioica).N Z Med J.(2007 Nov 9)
- ^Easton L, Vaid S, Nagel AK, Venci JV, Fortuna RJStinging Nettle (Urtica dioica): An Unusual Case of Galactorrhea.Am J Case Rep.(2021 Dec 8)
- ^Bhusal KK, Magar SK, Thapa R, Lamsal A, Bhandari S, Maharjan R, Shrestha S, Shrestha JNutritional and pharmacological importance of stinging nettle ( L.): A review.Heliyon.(2022-Jun)
- ^Ozen T, Korkmaz HModulatory effect of Urtica dioica L. (Urticaceae) leaf extract on biotransformation enzyme systems, antioxidant enzymes, lactate dehydrogenase and lipid peroxidation in mice.Phytomedicine.(2003)
- ^Bisht R, Joshi BC, Kalia AN, Prakash AAntioxidant-Rich Fraction of Urtica dioica Mediated Rescue of Striatal Mito-Oxidative Damage in MPTP-Induced Behavioral, Cellular, and Neurochemical Alterations in Rats.Mol Neurobiol.(2017 Sep)
- ^Semwal P, Rauf A, Olatunde A, Singh P, Zaky MY, Islam MM, Khalil AA, Aljohani ASM, Al Abdulmonem W, Ribaudo GThe medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity.Nat Prod Bioprospect.(2023 May 12)
- Anti-Oxidant Enzyme Profile - Namazi N, Tarighat A, Bahrami AThe effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: a randomized double-blind clinical trialPak J Biol Sci.(2012 Jan 15)
- Inflammation - Namazi N, Esfanjani AT, Heshmati J, Bahrami AThe effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: a randomized double-blind control trialPak J Biol Sci.(2011 Aug 1)
- Blood glucose - Tabrizi R, Sekhavati E, Nowrouzi-Sohrabi P, Rezaei S, Tabari P, Ghoran SH, Jamali N, Jalali M, Moosavi M, Kolahi AA, Bettampadi D, Sahebkar A, Safiri SEffects of on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials.Mini Rev Med Chem.(2022)
- Blood glucose - Ziaei R, Foshati S, Hadi A, Kermani MAH, Ghavami A, Clark CCT, Tarrahi MJThe effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis.Phytother Res.(2020-Feb)
- Osteoarthritis Symptoms - Keith Rayburn, Eric Fleischbein, Jessica Song, Blaine Allen, Mary Kundert, Charles Leiter, Thomas BushStinging nettle cream for osteoarthritisAltern Ther Health Med.(Jul-Aug 2009)
- Osteoarthritis Symptoms - Randall C, Randall H, Dobbs F, Hutton C, Sanders HRandomized controlled trial of nettle sting for treatment of base-of-thumb painJ R Soc Med.(2000 Jun)
- Inflammation - Teucher T, Obertreis B, Ruttkowski T, Schmitz HCytokine secretion in whole blood of healthy subjects following oral administration of Urtica dioica L. plant extractArzneimittelforschung.(1996 Sep)
- Testosterone - Safarinejad MRUrtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover studyJ Herb Pharmacother.(2005)
- Allergy Symptoms - Mittman PRandomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitisPlanta Med.(1990 Feb)
- Osteoarthritis Symptoms - Randall C, Dickens A, White A, Sanders H, Fox M, Campbell JNettle sting for chronic knee pain: a randomised controlled pilot studyComplement Ther Med.(2008 Apr)